Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: Comparison of NMDA, AMPA, and kainate receptors

Tarazi, Frank I.; Campbell, Andrea Louise; Yeghiayan, Sylva K.; Baldessarini, Ross J.

doi:10.1002/(sici)1098-2396(199810)30:2<227::aid-syn13>3.0.co;2-z

Cited by 80 publications

(65 citation statements)

References 63 publications

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Section: Discussionmentioning

confidence: 95%

“…Sections were then washed twice (5 min in ice-cold buffer), rinsed in deionized water, and air-dried. Dried sections were exposed to tritium-sensitive Kodak Hyperfilm for 2-6 weeks before standard photographic processing (Tarazi et al 1998a;Zhang et al 2001b). Radioligand binding was quantified with a computerized image analyzer (Image Research Inc.; St. Catherines, Ontario), and converted to nCi/mg tissue using [ 3 H]reference standards, with specific binding expressed as mean Ϯ S.E.M.…”

Section: Da Transporter and Receptor Autoradiographymentioning

confidence: 99%

“…Sections were then washed twice (5 min in ice-cold buffer), rinsed in deionized water, and air-dried. (Tarazi et al 1998a;Zhang et al 2001b). Nonspecific binding was determined with 10 M S( Ϫ )-sulpiride.…”

Section: Da Transporter and Receptor Autoradiographymentioning

confidence: 99%

“…In contrast to the temporary effects of neonatal 6-OHDA lesions on D 4 receptors, effects of such lesions in adult rats follow a different pattern. Selective destruction of nigrostriatal DA projections in adult rats increased D 4 receptor binding in CPu at five weeks but not one week after lesioning (Tarazi et al 1998a;Zhang et al 2001a), suggesting mechanisms for D 4 receptor regulation differ at specific developmental stages.Previously, we found no differences in D 4 receptor binding in NAc between sham-control and lesioned rats using procedures identical to those employed in the present study (Zhang et al 2001b). These seemingly inconsistent results may reflect antemortem exposure to D 4 -selective drugs in the previous study.…”

mentioning

confidence: 95%

“…However, altered coupling of D 4 receptors to G-proteins, or other downstream molecular events require further consideration. D 4 receptors are proposed to be present on glutamatergic terminals of corticostriatal projections from mPFC to CPu, based on studies of cortical ablation (Tarazi et al 1998a). Glutamatergic efferents from mPFC are important in limiting behavioral responses to various stimuli (Bubser and Schmidt 1990;Flores et al 1996;Wilkinson et al 1997;Lacroix et al 1998).…”

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confidence: 99%

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Plasticity of Dopamine D4 Receptors in Rat Forebrain Temporal Association with Motor Hyperactivity Following Neonatal 6-Hydroxydopamine Lesioning

Zhang

Tarazi

Davids

et al. 2002

Neuropsychopharmacology

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Genetic studies suggest that dopamine D 4 receptor polymorphism is associated with attention deficit hyperactivity disorder (ADHD). We recently reported that motor hyperactivity in juvenile male rats with neonatal 6-hydroxydopamine lesions of the central dopamine system canAttention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition characterized by hyperactivity, inattention and impulsivity, typically in school-aged boys (Barkley 1990). Abnormal dopamine (DA) neurotransmission has long been considered to underlie the disorder since most symptoms of ADHD can be alleviated by psychostimulant drugs, notably methylphenidate and amphetamines, that release DA among other actions. Increased radioligand binding to dopamine transporters (DAT) in patients with ADHD identified in recent brain imaging studies further implicates deficient DA functioning in the disorder (Dougherty et al. 1999;Dresel et al. 2000).DA modulates physiological processes through activation of five G-protein NO . 5 ADHD by genetic linkage studies (La Hoste et al. 1996). Human D 4 receptors occur in multiple forms with 2-11 copies of a 16-amino acid sequence in the putative third intracellular loop of the peptide (Van Tol et al. 1992;Lichter et al. 1993;Asghari et al. 1994). One such allele is the D 4.7 receptor, containing seven repeats of this sequence. It has repeatedly been associated with ADHD, as well as related behavioral traits such as novelty-seeking and impulsivity (Benjamin et al. 1996;Ebstein et al. 1996;La Hoste et al. 1996;Bailey et al. 1997;Rowe et al. 1998;Swanson et al. 1998;Faraone et al. 1999;Barr et al. 2000).Some features of ADHD are simulated in several laboratory models, including: (1) rats with neonatal lesions of the central DA system induced by the neurotoxin 6-hydroxydopamine (6-OHDA; Shaywitz et al. 1976); (2) the spontaneously hypertensive Kyoto-Wistar rat (Tucker and Johnson 1981); (3) nonhuman primates treated with the DA neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; Roeltgen and Schneider 1991); and (4) genetic knock-out mice lacking functional DAT (Giros et al. 1996). Juvenile male rats with neonatal 6-OHDA lesions are a particularly appropriate model for the hyperactivity of ADHD in that lesion-induced motor hyperactivity is most prominent at an age corresponding to human periadolescence (Shaywitz et al. 1976;Erinoff et al. 1979), and is dose-dependently antagonized by stimulants used to treat clinical ADHD (Heffner and Seiden 1982). In addition, the model is associated with learning deficits that are also antagonized by stimulants (Takasuna and Iwasaki 1996;Wool et al. 1987).We found recently that motor hyperactivity following 6-OHDA lesioning of neonatal rats can be reversed dose-dependently by selective antagonists for D 4 but not D 2 receptors, and exacerbated by a D 4 agonist (Zhang et al. 2001b). In addition, motor hyperactivity correlated closely with the magnitude of increased D 4 , but not D 2 receptor binding in basal forebrain. The present study further inv...

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Section: Discussionmentioning

confidence: 95%

Section: Da Transporter and Receptor Autoradiographymentioning

confidence: 99%

Section: Da Transporter and Receptor Autoradiographymentioning

confidence: 99%

mentioning

confidence: 95%

mentioning

confidence: 99%

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Plasticity of Dopamine D4 Receptors in Rat Forebrain Temporal Association with Motor Hyperactivity Following Neonatal 6-Hydroxydopamine Lesioning

Zhang

Tarazi

Davids

et al. 2002

Neuropsychopharmacology

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Regional localization of dopamine and ionotropic glutamate receptor subtypes in striatolimbic brain regions

Tarazi

Baldessarini

1999

J. Neurosci. Res.

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Localization of dopamine (D(1)-, D(2)-like, and D(4)) and ionotropic glutamate (NMDA, AMPA, and KA) receptor subtypes within the striatolimbic forebrain remains incomplete, but basic to understanding the functional organization of this important brain region. We found that frontal cortical ablation supported colocalization of D(4) and NMDA receptors on corticostriatal afferents to caudate-putamen and nucleus accumbens in rat forebrain. Local injection of kainic acid into caudate-putamen, nucleus accumbens, or hippocampus produced massive local postsynaptic losses of D(1)- and D(2)-like, as well as NMDA, AMPA, and KA receptors, and kainic acid ablation of hippocampal-striatal projections indicated the selective expression of presynaptic NMDA and KA autoreceptors. Degeneration of nigrostriatal dopamine projections with 6-hydroxydopamine showed that all three glutamatergic subtypes exist as heteroceptors on nigrostriatal dopaminergic terminals. Our findings suggest common interactions between excitatory glutamatergic and inhibitory dopaminergic receptors in rat forebrain. Further localization of these receptor subtypes in striatolimbic forebrain should help to clarify their contributions to the pathophysiology of neuropsychiatric disorders and their treatment.

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Presence of NMDA-type glutamate receptors in cingulate corticostriatal terminals and their postsynaptic targets

Wang

Pickel

2000

Synapse

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The glutamatergic projection from the anterior cingulate cortex to the medial caudate-putamen nucleus (CPN) has been implicated in motor and cognitive functions, many of which are potently modulated by activation of N-methyl-D-aspartate subtype of glutamate receptors (NMDARs). To determine the functional sites for NMDAR activation within this circuitry, we combined anterograde transport of biotinylated dextran amine (BDA) from deep layers of the rat anterior cingulate cortex with immunogold labeling of NMDAR subunit, NMDAR1, in the dorsomedial CPN. BDA-containing axons were seen in patch-like clusters in a neuropil that showed more uniform immunogold-silver labeling for NMDAR1. Electron microscopy of these regions showed that BDA-labeling was present exclusively in axons and terminals, 23% (98 of 421) of which also contained NMDAR1-immunoreactivity (IR). BDA-labeled terminals often apposed NMDAR1-immunoreactive neuronal and glial profiles. These terminals also formed asymmetric excitatory-type synapses with dendritic spines. Of 155 anterogradely labeled axon terminals forming asymmetric synapses, 34% were with NMDAR1-labeled, and 66% with unlabeled dendritic spines. These results provide ultrastructural evidence for the involvement of NMDARs in presynaptic regulation of glutamate transmission, and in postsynaptic modulation of the excitability of spiny neurons in patch-like compartments of the dorsomedial CPN. These dual NMDAR-mediated actions are likely to play a major role in the acquisition of new behaviors and reward-related processes that have been associated with cortical input to the striatal patch compartments.

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Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: Comparison of NMDA, AMPA, and kainate receptors

Cited by 80 publications

References 63 publications

Plasticity of Dopamine D4 Receptors in Rat Forebrain Temporal Association with Motor Hyperactivity Following Neonatal 6-Hydroxydopamine Lesioning

Plasticity of Dopamine D4 Receptors in Rat Forebrain Temporal Association with Motor Hyperactivity Following Neonatal 6-Hydroxydopamine Lesioning

Regional localization of dopamine and ionotropic glutamate receptor subtypes in striatolimbic brain regions

Presence of NMDA-type glutamate receptors in cingulate corticostriatal terminals and their postsynaptic targets

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