Localization of splenic cells with antigen‐transporting capability in the chicken

Abstract

The results suggest that migrating EAC have a role as both antigen-transporting cell and antigen-presenting cell in the T- and B-dependent areas, as a result of which migrating EAC is transiently found in periellipsoidal white pulp, then periarteriolar lymphoid sheaths, and finally germinal centers, where it may function as an interdigitating cell or as a follicular dendritic cell, depending on its location. Thus, we conclude that the EACs are precursors of both interdigitating and follicular dendritic cells.

Identification of avian dendritic cells in the spleen using a monoclonal antibody specific for chicken follicular dendritic cells

“…On the other hand, a few 74.3 ؉ cells were found in the PWP, which is in agreement with previous reports describing migrating EAC in this location (Olah and Glick, 1992;Gallego et al, 1993;Del Cacho et al, 1995). This finding is consistent with the hypothesis that the EAC may enter the circulating blood via the PWP Del Cacho et al, 1995;.…”

“…Since there is evidence that antigen-triggered EAC migrate to the red pulp and enter into the circulation via sinuses Gallego et al, 1993Gallego et al, , 1995Del Cacho et al, 1995), Pharr et al (1995) suggested that these inner cells are immigrant EAC, which may leave the circulation by way of the penicilliform capillaries. Alternatively, these inner cells may be a precursor of the EAC on the surface of the ellipsoid (Pharr et al, 1995).…”

“…Previous reports on chicken dendritic cells have suggested that the ellipsoid associated cells (EAC), the antigen-binding cells which are located on the surface of the Schweigger-Seidel sheaths (ellipsoids) (Olah and Glick, 1982), are precursors of follicular dendritic cells (FDC) and interdigitating cells (ID) Gallego et al, 1993;del Cacho et al, 1995). Evidence has been provided that internalization of antigen by the EAC (White et al, 1975;Olah and Glick, 1982; or retention of immune complexes on the surface of the EAC (Nagy et al, 1973;del Cacho et al, 1995) triggers the cell to detach from the surface of the ellipsoid.…”

“…Evidence has been provided that internalization of antigen by the EAC (White et al, 1975;Olah and Glick, 1982; or retention of immune complexes on the surface of the EAC (Nagy et al, 1973;del Cacho et al, 1995) triggers the cell to detach from the surface of the ellipsoid. Thereafter, these antigen-binding EAC migrate to the white pulp Gallego et al, 1993Gallego et al, , 1995.…”

“…Thereafter, these antigen-binding EAC migrate to the white pulp Gallego et al, 1993Gallego et al, , 1995. There they function as antigenpresenting cells, namely ID and FDC del Cacho et al, 1995). The antigen-binding EAC which are precursors of ID remain in the periarteriolar lymphatic sheaths (PALS) as scattered single cells.…”