Structural Evolution of the Spleen in Man and Mouse

Balogh, Péter; Lábadi, Árpád

doi:10.1007/978-3-642-14429-5_11

Cited by 8 publications

(8 citation statements)

References 95 publications

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“…PALS, follicles and marginal zone develop in the mid gestational period and towards the end of this trimester the red and white pulp are clearly distinguishable[46][47][48][49].3.2.2.1.2. Postnatal.…”

mentioning

confidence: 99%

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Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies

Kuper¹,

Bilsen²,

Cnossen³

et al. 2016

Reproductive Toxicology

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mentioning

confidence: 99%

“…At birth the structure of the spleen appears already fully developed and the spleen changes in dimensions rather than morphology. Hematopoietic foci in the red pulp disappear after birth[46][47][48].…”

mentioning

confidence: 99%

Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies

Kuper¹,

Bilsen²,

Cnossen³

et al. 2016

Reproductive Toxicology

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“…Although important anatomical differences between humans and rodents exist, multiple morphological features are conserved [26]. This fact, together with observations on malaria responses in animal models gives rise to the question on whether spleen-dependent mechanisms of immunity against malaria might in fact, be redundant.…”

Section: Conserved and Differential Features Of Human And Murine Splementioning

confidence: 99%

“…Balogh et al recently reviewed in great detail the reported observations on differences existing between human and mice spleens, gathered through the use of a variety of immunohistochemistry, confocal, and advanced fluorescence microscopy techniques [26]. A key splenic component that shows significant differences between human and mice is the marginal zone (MZ).…”

Section: Conserved and Differential Features Of Human And Murine Splementioning

confidence: 99%

Imaging of the spleen in malaria

Ferrer

Martín-Jaular

Niz

et al. 2014

Parasitology International

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Splenomegaly, albeit variably, is a hallmark of malaria; yet, the role of the spleen in Plasmodium infections remains vastly unknown. The implementation of imaging to study the spleen is rapidly advancing our knowledge of this so-called "blackbox" of the abdominal cavity. Not only has ex vivo imaging revealed the complex functional compartmentalization of the organ and immune effector cells, but it has also allowed the observation of major structural remodeling during infections. In vivo imaging, on the other hand, has allowed quantitative measurements of the dynamic passage of the parasite at spatial and temporal resolution. Here, we review imaging techniques used for studying the malarious spleen, from optical microscopy to in vivo imaging, and discuss the bright perspectives of evolving technologies in our present understanding of the role of this organ in infections caused by Plasmodium.

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“…However, spleen remodeling is a dynamic and complicated response, and ex vivo studies alone do not provide sufficient information to understand disease development and predict disease outcome. On the other hand, though there are anatomical differences between human and mouse spleens, many morphological features of the spleen are conserved ( 36 ). In addition, the rodent malaria model organism P. yoelii has long been employed in malaria research to complement the research on human malaria.…”

Section: Introductionmentioning

confidence: 99%

Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections

Huang

Ong

Lim

et al. 2016

mSphere

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The spleen and its response to parasite infection are important in eliminating parasites in malaria. By comparing P. yoelii parasite lines with different disease outcomes in mice that had either intact spleens or had had their spleens removed, we showed that upon parasite infection, the spleen exhibits dramatic changes that can affect parasite clearance. The spleen itself directly impacts RBC deformability independently of parasite genetics. The data indicated that the changes in the biomechanical properties of malaria parasite-infected RBCs are the result of the complex interaction between host and parasite, and RBC deformability itself can serve as a novel predictor of clinical outcome. The results also suggest that early responses in the spleen are a key factor directing the clinical outcome of an infection.

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Structural Evolution of the Spleen in Man and Mouse

Cited by 8 publications

References 95 publications

Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies

Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies

Imaging of the spleen in malaria

Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections

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