“…Rabl (1885) (Sperling and Ludtke, 1981;Cremer et al, 1982;Foe and Alberts, 1985). Furthermore, direct analysis of chromosome topography by three-dimensional microscopy indicates that the ends of interphase chromosomes are close to the nuclear envelope in a wide variety of eukaryotes (Agard and Sedat, 1983;Mathog et al, 1984;Hochstrasser et al, 1986;Mathog and Sedat, 1989;van Dekken et al, 1989;Chung et al, 1990;Rawlins et al, 1991). These cytological data suggest that telomeres could be attached to the nuclear envelope.…”