Localization of the central antinociceptive effects of diclofenac in the rat

Involvement of serotonin mechanisms in the antinociceptive effect of S(+)‐ketoprofen

“…Evidence has been provided that the antinociceptive effect of NSAIDs involves central mechanisms [Herrero et al, 1997;Bjö rkman et al, 1992]. Thus, the racemic mixture of ketoprofen was reported to cross the blood-brain barrier and was detected in cerebrospinal fluid 15 min after intramuscular administration [Netter et al 1985].…”

Pain Management After Thoracic Surgery

“…NSAIDs block the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase. NSAIDs reduce the inflammatory response to surgical trauma, have a peripheral non-prostaglandin analgesic effect [64] and act centrally [65] in part by inhibiting prostaglandin synthesis in the spinal cord [66]. The side effects of NSAIDs are well known and include gastrointestinal mucosal damage [67], renal tubular and platelet dysfunction [68].…”

In Vitro Dissolution Study and Assay of Diclofenac Sodium from Marketed Solid Dosage form in Bangladesh

“…Their opioid sparing effect and availability in parenteral forms make them ideal for day-only and short-stay admissions for elective surgery [9][10][11][12]. The rational for their use is that they produce inhibition of peripheral hyperalgesia mediated by their anti-inflammatory properties 13, possibly supplemented by centrally mediated actions that attenuate central sensitization [13][14][15][16][17]. Available drugs in Bangladeshi market are Aceclofenac, Dexibuprofen, Dexketoprofen, Diclofenac diethyl ammonium salt, Diclofenac free acid, Diclofenac potassium, Diclofenac sodium, Diclofenac Sodium+Misoprostol, Etodolac, Naproxen, etc.…”