Localization of tumor by chemiluminescence probe during photosensitization action

Feasibility of Using Fluoresceinyl Cypridina Luciferin Analog in a Novel Chemiluminescence Method for Real‐time Photodynamic Therapy Dosimetry

“…This indicates that the CL observed in the study was mainly from 1 O 2 . The results from the current cell measurement are in good agreement with that from our previous study in a cell‐free system (17–20). The discrepancy between the results from MTT and colony formation assays may be because they are looking at different biological end points.…”

“…A 1 O 2 and superoxide specific chemiluminescence (CL) probe, fluoresceinyl Cypridina luciferin analog (FCLA), can transform the energy of 1 O 2 to 532 nm photons detectable by conventional photomultiplier tubes (PMT) (13–16). We have previously reported the detection of FCLA‐CL from 1 O 2 from both transplanted tumor and cell‐free solution treated with either PDT or sonodynamic therapy using an intensified charge‐coupled device system (17–20). The present study further explores the potential use of FCLA‐CL as an alternative PDT dosimeter in real time.…”

A novel high selectivity sensor for tetradifon residues based on double-side hollow molecularly imprinted materials

“…[1][2][3] Since the appearance of highly sensitive photomultipliers (PMT) in the 1950s, which is a simple instrument with low detection limit, large calibration ranges and rapid analysis speed, chemiluminescence (CL) has become one of the most sensitive detection methods, 4 and has been widely used in practical applications during the last 50 years. [5][6][7][8][9][10][11][12][13] However, traditional CL suffers from poor selectivity and in some circumstances a screening agent has to be used to erase interference from coexisting substances. Thus, it is important to develop the CL technology to detect tetradifon residues in the environment.…”

In vivo detection of chemiluminescence to monitor photodynamic threshold dose for tumor treatment

“…21 We have reported that CL is selective and sensitive for ROS detection, and has the potential for usage in vivo. 22,23 In our previous study, we used a CL probe FCLA (fluorescenyl cypridina luciferin analog) to detect 1 O 2 for tumor diagnosis, in in vitro PDT, and on normal skin treatment with PDT. 23, 24 All the results showed a good possibility of CL application to tumor dosimetry.…”