Localized Cutaneous Histoplasmosis

A Case of Disseminated Histoplasmosis

“…Serological methods include various complement-fixation and agglutination tests, and as these become positive at different stages of the disease (Campbell, 1958) they are best employed altogether at any one time. Biopsy has been said to precipitate dissemination of the disease, but Symmers (1956) believes that this danger may be exaggerated. His three patients were still alive and well, three years after biopsy, without any evidence of dissemination of the disease (Symmers, 1959, personal communication).…”

“…It may, however, present as a granulomatous or ulcerating infection of the upper respiratory tract (Parkes and Burtoff, 1949;Roberts and Forman, 1950;Hutchison, 1952;Poles and l avertine, 1954) or of tongue or oral cavity (Rawson, et al, 1948;Charr, 1953 ;Locket et al, 1953). In other cases enlargement of the lymph nodes may be the only sign, and practically any type of skin lesion may be mimicked (Derry et al, 1942;Miller et al, 1947;Symmers, 1956). The primary pulmonary form of the disease has an excellent prognosis, but the localized forms are more serious and the disseminated type is often fatal (Price, 1956).…”

“…When the disease becomes established, however, it is the yeast-like phase which invades the tissue cells. Fuller descriptions of various aspects of the disease can be found in the Proceedings of the Conference on Histoplasmosis, 1952 (Schwarz, 1956); and in the papers of Parsons and Zarafonetis (1945), Mochi and Edwards (1952), Silverman et al (1955), Edwards et al (1956), and Symmers (1956) amongst others. Symmers (1956), speaking of Britain and discussing all forms of the disease, said: " Histoplasmosis has seldom been recognized in this country, where it is looked upon as an exotic disease and consequently has attracted little attention."…”

Histoplasmose cutânea primária: relato de caso em paciente imunocompetente e revisão de literatura

“…O paciente foi acompanhado durante um ano após o término do tratamento, sem sinais ou sintomas de recorrência da doença. 22 23 , dois sem antecedentes de trauma 21 , um associado a suposto trauma no pé 1 , e uma suposta transmissão venérea 17 . Desde então, os relatos têm sido esporádicos, os mais recentes associados a um estado de imunossupressão: um com papuloeritrodermia 13 , um com artrite reumatóide em terapia imunossupressora 14 , dois com asma brônquica em uso de corticoterapia sistêmica 6 9 , um com diabetes mellitus 11 , um com síndrome da imunodeficiência adquirida 10 , e dois em crianças 2 24 .…”

A case report of primary cutaneous histoplasmosis requiring deep tissue sampling for diagnosis

“…Disseminated infections usually occur in immunosuppressed patients with human immunodeficiency virus, cancer, leukemia, lymphoma, diabetes, collagen vascular disease, renal transplants or patients on anti-TNF alpha therapy [2]. Primary cutaneous histoplasmosis without evidence of systemic infection is extremely rare and has been reported in only a few cases [2][3][4][5][6][7][8][9][10]. We present a case of 34-year-old Caucasian male who presented with extensive necrosis and ulceration of his right thigh and required a deep tissue biopsy with a histoplasmosis DNA probe assay (after several nondiagnostic punch biopsies) to render a diagnosis of primary cutaneous histoplasmosis.…”