Localized internal radiotherapy with 90Y particles embedded in a new thermosetting alginate gel: A feasibility study in pigs

Holte, O; Skretting, Arne; Bach‐Gansmo, Tore; Hol, Per Kristian; Johnsrud, Kjersti; Tønnesen, Hanne; Karlsen, Jan T.

doi:10.1097/01.mnm.0000194398.97195.d9

Cited by 6 publications

(2 citation statements)

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“…Advantageously, alginate gels can be entrapped at target sites where they are injected. [49] 3.6 | Ultrastructural characterization by AFM imaging AFM is a powerful and versatile imaging platform that has been applied to investigate biopolymers at nanometer scales. [50] We used AFM to probe topographic features of the microgels to determine local structures at alginate interfaces.…”

Section: Nanoparticle Release Kineticsmentioning

confidence: 99%

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

et al. 2021

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Efficient delivery of nanometric vectors complexed with nanoparticles at a target tissue without spreading to other tissues is one of the main challenges in gene therapy. One means to overcome this problem is to confine such vectors within microgels that can be placed in a target tissue to be released slowly and locally. Herein, a conventional optical microscope coupled to a common smartphone was employed to monitor the microfluidic production of monodisperse alginate microgels containing nanoparticles as a model for the encapsulation of vectors. Alginate microgels (1.2%) exhibited an average diameter of 125 ± 3 μm, which decreased to 106 ± 5 μm after encapsulating 30 nm fluorescent nanoparticles. The encapsulation efficiency was 70.9 ± 18.9%. In a 0.1 M NaCl solution, 55 ± 5% and 92 ± 4.7% of nanoparticles were released in 30 minutes and 48 hours, respectively. Microgel topography assessment by atomic force microscopy revealed that incorporation of nanoparticles into the alginate matrix changes the scaffold's interfacial morphology and induces crystallization with the appearance of oriented domains. The high encapsulation rate of nanoparticles, alongside their continuous release of nanoparticles over time, makes these microgels and the production unit a valuable system for vector encapsulation for gene therapy research.

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Section: Nanoparticle Release Kineticsmentioning

confidence: 99%

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

et al. 2021

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“…for cardiac diseases or cardiotoxicity testing, the prediction of those properties is of high interest in applied research. In addition, cross-linking of the alginate solution leads to considerable changes in diffusion properties of cross-linkers [6] as well as availability of open alginate crosslinking sites [7]. This may lead to a non-uniform degree of cross-linking within a gelled alginate body, concentration, mobility and mechanical gradients, that vice versa effect local cross-linking rates.…”

Section: Introductionmentioning

confidence: 99%

A multiphase model for the cross‐linking of ultra‐high viscous alginate hydrogels

Diebels

Gepp

Meiser

et al. 2021

Proc Appl Math and Mech

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Clinical Uses of Alginate

Nussinovitch

2011

Biodegradable Polymers in Clinical Use and Clinical Development

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Localized internal radiotherapy with 90Y particles embedded in a new thermosetting alginate gel: A feasibility study in pigs

Abstract: The present formulation appears suitable for localized radiotherapy in organs and tissues having low perfusion.

Cited by 6 publications

References 27 publications

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

A multiphase model for the cross‐linking of ultra‐high viscous alginate hydrogels

Clinical Uses of Alginate

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