Localized juvenile spongiotic gingival hyperplasia featuring unusual p16<scp>INK</scp>4A labeling and negative human papillomavirus status by polymerase chain reaction

Argyris, Prokopios P.; Nelson, Andrew C.; Papanakou, S.; Merkourea, Stavroula; Tosios, Konstantinos I.; Koutlas, Ioannis G.

doi:10.1111/jop.12214

Cited by 29 publications

(80 citation statements)

References 14 publications

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“…The strong age predilection suggests a possible role for the sex hormones of puberty in the etiopathogenesis of LJSGH. However, immunohistochemical studies for the presence of estrogen and progesterone receptors have been negative . Additionally, the papillary architecture of the lesion raises the possibility of human papillomavirus (HPV) as an etiologic factor .…”

Section: Discussionmentioning

confidence: 99%

“…However, immunohistochemical studies for the presence of estrogen and progesterone receptors have been negative . Additionally, the papillary architecture of the lesion raises the possibility of human papillomavirus (HPV) as an etiologic factor . However, LJSGH usually lacks the characteristic histopathologic features seen in HPV‐related lesions, particularly koilocytosis .…”

Section: Discussionmentioning

confidence: 99%

“…Only one case showed definitive positivity (HPV 31). The authors concluded that the p16INK4A immunoreactivity was attributed to the intense inflammatory reaction and that HPV was not involved in the pathogenesis of LJSGH …”

Section: Discussionmentioning

confidence: 99%

“…Localized juvenile spongiotic gingival hyperplasia (LJSGH) is an unusual and distinct subtype of gingival inflammatory hyperplasia that usually affects the anterior facial gingiva in young patients, most commonly in the second decade of life . There seems to be a female predilection of about 2:1 . Clinically, it is generally characterized as a solitary, small lesion, with a micropapillary or granular surface and a bright red gingival overgrowth.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, it is generally characterized as a solitary, small lesion, with a micropapillary or granular surface and a bright red gingival overgrowth. LJSGH is painless and may bleed easily during oral hygiene procedures . The attached gingiva of the anterior maxilla is the most common location, with variable marginal gingival involvement .…”

Section: Introductionmentioning

confidence: 99%

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Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Fernandes

Wright

Lopes

et al. 2018

Clin Adv Periodontics

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Introduction The aim of this case report is to present a distinct subtype of gingival inflammatory hyperplasia, providing information to avoid diagnostic mistakes and overtreatment. Also, an unexpected progression of the lesion is shown. Furthermore, a review of the literature to discuss the pathogenesis, diagnosis, treatment, and the need for new therapeutic approaches is presented. Case Series The authors report four cases of localized juvenile spongiotic gingival hyperplasia involving the anterior maxillary gingiva with distinct clinical features. The patients were followed for a period of 1 to 9 years, and the evolution of the lesions was documented. Surgical excision or therapy by topical steroids was used to treat the lesions. Conclusions The long‐term follow‐up provides important information for clinicians not to eliminate older patients for lesion diagnosis. Although surgical excision should not be recommended for all cases, considering the risk of esthetic problems, the treatment modality using topical steroids was not permanently effective in the authors’ cases. Investigations about new esthetic treatment modalities for lesions are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Fernandes

Wright

Lopes

et al. 2018

Clin Adv Periodontics

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Characterization of juvenile spongiotic gingival hyperplasia as an entity of odontogenic origin

Mendoza

Alberdi-Navarro

Marichalar-Mendía

et al. 2019

Journal of Periodontology

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Background Juvenile spongiotic gingival hyperplasia (JSGH) is a distinct clinicopathological entity of the buccal gingiva of young patients which has been related to several factors such as plaque formation, hormonal modifications, and viral infections; however, its true etiopathogenesis remains unsolved. Several immunohistochemical studies have demonstrated the similarity between the junctional epithelium (JE) and the hyperplasic epithelium of JSGH. The objective of this study is to analyze the clinicopathological and immunohistochemical characteristics of JSGH to explain its origin. Methods Clinicopathlogical data of 10 cases of JSGH (five men and five women) with a mean age of 13 years (range: 9 to 17 years) were collected. CK7, CK14, CK19, CD3, CD20, S100, and Ki‐67 antibodies were used for comparative immunohistochemical study. Results All the lesions showed hyperplasic epithelium in its central portion, exhibiting marked spongiosis, vascular proliferation, and a chronic inflammatory infiltrate on the subepithelial connective tissue. CK19 was positive in the whole hyperplasic epithelium of JSGH and the basal layer of the marginal gingiva, while expression of CK14 was present in all epithelial layers of both the JSGH and that of the marginal gingiva. The subepithelial inflammatory infiltrate has a larger amount of CD20 positive cells. Conclusion JSGH is a reactive tumor of the gingiva that may have an odontogenic etiology, whose origin seems to be the remnants of JE.

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Gingival Pathology

Hegarty¹,

Rich²

2017

Contemporary Oral Medicine

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Localized juvenile spongiotic gingival hyperplasia featuring unusual p16INK4A labeling and negative human papillomavirus status by polymerase chain reaction

Abstract: Human papillomavirus does not participate in the pathogenesis of LJSGH. P16INK4A expression in the absence of detectable HPV DNA can likely be attributed to the intense inflammation associated with LJSGH.

Cited by 29 publications

References 14 publications

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Characterization of juvenile spongiotic gingival hyperplasia as an entity of odontogenic origin

Gingival Pathology

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