Localized mycosis fungoides of the bilateral thumbs and nail units treated with orthovoltage radiation

Mazzurco, Jason D.; Schapiro, Brian; Fivenson, David P.

doi:10.1111/j.1365-4632.2010.04649.x

Cited by 5 publications

(14 citation statements)

References 5 publications

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“…In fact, the average age at diagnosis of our patients was 61.6 years, while the frequency of onychauxis is 84%, which is due to onychomycosis in 59% to 75%. 19,20 Several previous studies 6,15-17,21-24 performed nail biopsies to confirm the specificity of onychodystrophy and some demonstrated cells of specific clonality infiltrating the nail plate. 17,21,22,24 We observed a patient with SzS who presented with trachionychia, yellow nail discoloration, onychomadesis, onychauxis, splinter hemorrhages, and paronychia.…”

Section: Discussionmentioning

confidence: 98%

“…19,20 Several previous studies 6, [15][16][17][21][22][23][24] performed nail biopsies to confirm the specificity of onychodystrophy and some demonstrated cells of specific clonality infiltrating the nail plate. 17,21,22,24 We observed a patient with SzS who presented with trachionychia, yellow nail discoloration, onychomadesis, onychauxis, splinter hemorrhages, and paronychia. After 14 months of treatment with methotrexate, he demonstrated significant clinical response with disappearance of Sézary cells from the peripheral blood, which correlated with compete resolution of his onychodystrophy ( Figure 3).…”

Section: Discussionmentioning

confidence: 99%

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Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature

2019

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Background: The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications. Objectives: The objectives of this study were to identify and describe the most frequent nail alterations in patients with SzS. Methods: A retrospective analysis was performed with some prospective observations at the University of Pittsburgh from 1989 to 2017. Results: We identified 54 patients with SzS out of 535 patients with cutaneous T-cell lymphoma. Nineteen patients with SzS had photos of their nail. All those patients exhibited some type of onychodystrophy. The most common types were paronychia (63.2%; 12/19), leukonychia (42.1%; 8/19), onycholysis (42.1%; 8/19), trachyonychia (31.6%; 6/19), and subungual hyperkeratosis (26.3; 5/19). Cluster analysis of our data in comparison with published data on the psoriatic nails indicated that while leukonychia, onycholysis, subungual hyperkeratosis, and nail discoloration were frequently observed in psoriasis, onychauxis, anonychia, distal notching, and onychoschizia occurred more commonly in patients with SzS. Conclusions: The most common nail manifestations in SzS patients included paronychia, leukonychia, and onycholysis. The nail manifestations in SzS patients appeared to be heterogeneous, while onychauxis, anonychia, distal notching, and onychoschizia seem to be specific to SzS in comparison with psoriasis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature

2019

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“…Onycholysis has been reported in several cases of MF [2,3,5,6] and is caused by detachment of the nail from the nail bed at the distal and/or lateral attachment sites. It generally extends proximally until it reaches the nail matrix and can progress to onychomadesis.…”

Section: Discussionmentioning

confidence: 99%

“…Previously reported cases of biopsy-confirmed MF have included nail discoloration [2,3,4], thickening [2,3,4,5], onycholysis [3,5,6], onychomadesis [2], subungual hyperkeratosis [5], pterygia formation [6,7], and other, less specific changes. Plaque and tumor stage MF has also been associated with the ‘yellow nail syndrome', which is characterized by specific nail alterations and may present with chronic respiratory disorders and lymphatic dysplasia [2].…”

Section: Discussionmentioning

confidence: 99%

“…Pterygia appear as a progressive, wing-shaped scar in the nail area and cause irreversible damage [8]. Mazzurco et al [6] described a patient with a 10-year history of nail lichen planus who presented with erythematous, fissuring, scaling plaques in the bilateral thumb-nail folds and stable onycholysis with pterygia formation in the remaining 8 nails. Biopsies of the nail bed and matrix confirmed the presence of ungual MF.…”

Section: Discussionmentioning

confidence: 99%

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Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

Bishop

Wulkan

Kerdel

et al. 2015

Skin Appendage Disord

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Background: Cutaneous T-cell lymphoma (CTCL) encompasses a broad range of lymphoproliferative diseases affecting the skin and can be clinically misleading due to its variable presentation. Nail alterations commonly appear in advanced-stage mycosis fungoides and true Sézary syndrome; however, they may be present in any stage of the disease. Although proper recognition of nail involvement in CTCL has both clinical and therapeutic value, specific nail findings have been infrequently described in the current literature. Observations: We describe 4 patients with CTCL who presented with clinically significant nail alterations. The most common findings were nail discoloration, thickening, crumbling, onycholysis, and onychomadesis. Other notable findings included splinter hemorrhages, subungual hyperkeratosis, and anonychia. Conclusions and Message: The described cases illustrate many of the documented nail findings associated with CTCL and emphasize the variable nature of nail manifestations. The presence of specific nail alterations should increase the clinical suspicion of CTCL - especially in patients with concomitant systemic and/or cutaneous manifestations - and early biopsy specimens should be taken for diagnosis. Nail alterations should also be accurately described and monitored in all patients with biopsy-confirmed CTCL to help identify treatment response and detect disease recurrence.

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The Nail in Systemic Disease

Holzberg

Piraccini

2018

Baran &Amp; Dawber's Diseases of the Nails and Their Management

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Localized mycosis fungoides of the bilateral thumbs and nail units treated with orthovoltage radiation

Cited by 5 publications

References 5 publications

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature

Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

The Nail in Systemic Disease

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