Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes

Williamson, Adam; Ferro, Marc; Leleux, Pierre; Ismailova, Esma; Kaszás, Attila; Doublet, Thomas; Quilichini, Pascale; Rivnay, Jonathan; Rózsa, Balázs; Katona, Gergely; Bernard, Christophe; Malliaras, George G.

doi:10.1002/adma.201500218

Cited by 149 publications

(178 citation statements)

References 22 publications

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“…Gas sensing with PEDOT:PSS OECTs was performed by adjusting the polymer thickness resulting in a response to nitric oxide with a limit of detection of 350 ppb (Lin et al 2009). Similar devices were also used for in vitro cell action potential measurements (Cellot et al 2015), and for in vivo applications (Khodagholy et al 2011;Ludwig et al 2006;Williamson et al 2015). The gating mechanism of the OECTs to record electrophysiological signals differs drastically from that of the classical silicon fieldeffect transistors (FET) where capacitive coupling of signal components and purely potentiometric sensing is done to record the ionic currents occurring in cell action potentials.…”

Section: Introductionmentioning

confidence: 99%

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Hempel

Law

Nguyen

et al. 2017

Biosensors and Bioelectronics

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Section: Introductionmentioning

confidence: 99%

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Hempel

Law

Nguyen

et al. 2017

Biosensors and Bioelectronics

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“…Indeed, organic electrochemical transistors are a type of electrolyte-gated transistors in which the constituting semiconducting ionomer blend has a good affinity with cations. As such, this platform is extensively studied as a bio-electronical interface to measure neural activity [7,8,9]. Nowadays, one of the key challenges for this technological tool is to interpret complex readouts of dense networks.…”

Section: Introductionmentioning

confidence: 99%

Concentric-Electrode Organic Electrochemical Transistors: Case Study for Selective Hydrazine Sensing

Pecqueur

Lenfant

Guérin

et al. 2017

Sensors

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We report on hydrazine-sensing organic electrochemical transistors (OECTs) with a design consisting of concentric annular electrodes. The design engineering of these OECTs was motivated by the great potential of using OECT sensing arrays in fields such as bioelectronics. In this work, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-based OECTs have been studied as aqueous sensors that are specifically sensitive to the lethal hydrazine molecule. These amperometric sensors have many relevant features for the development of hydrazine sensors, such as a sensitivity down to 10−5 M of hydrazine in water, an order of magnitude higher selectivity for hydrazine than for nine other water-soluble common analytes, the capability to entirely recover its base signal after water flushing, and a very low operation voltage. The specificity for hydrazine to be sensed by our OECTs is caused by its catalytic oxidation at the gate electrode, and enables an increase in the output current modulation of the devices. This has permitted the device-geometry study of the whole series of 80 micrometric OECT devices with sub-20-nm PEDOT:PSS layers, channel lengths down to 1 µm, and a specific device geometry of coplanar and concentric electrodes. The numerous geometries unravel new aspects of the OECT mechanisms governing the electrochemical sensing behaviours of the device—more particularly the effect of the contacts which are inherent at the micro-scale. By lowering the device cross-talk, micrometric gate-integrated radial OECTs shall contribute to the diminishing of the readout invasiveness and therefore further promote the development of OECT biosensors.

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“…The same research group realized the architecture reported in [129] over a rigid and removable shuttle, hence fabricating a penetrating and flexible neural interface, where an OECT and an adjacent surface electrode can be inserted deep into the brain [130]. The surface electrode could be used as a local gate for each transistor, as a sink for stimulation currents, or as a simple recording and/or stimulating electrode.…”

Section: Organic Field-effect Transistorsmentioning

confidence: 99%

Flexible and Organic Neural Interfaces: A Review

Lago

Cester

2017

Applied Sciences

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Featured Application: Authors are encouraged to provide a concise description of the specific application or a potential application of the work. This section is not mandatory.Abstract: Neural interfaces are a fundamental tool to interact with neurons and to study neural networks by transducing cellular signals into electronics signals and vice versa. State-of-the-art technologies allow both in vivo and in vitro recording of neural activity. However, they are mainly made of stiff inorganic materials that can limit the long-term stability of the implant due to infection and/or glial scars formation. In the last decade, organic electronics is digging its way in the field of bioelectronics and researchers started to develop neural interfaces based on organic semiconductors, creating more flexible and conformable neural interfaces that can be intrinsically biocompatible. In this manuscript, we are going to review the latest achievements in flexible and organic neural interfaces for the recording of neuronal activity.

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Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes

Cited by 149 publications

References 22 publications

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Concentric-Electrode Organic Electrochemical Transistors: Case Study for Selective Hydrazine Sensing

Flexible and Organic Neural Interfaces: A Review

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