PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Hempel, Felix; Law, Jessica Ka-Yan; Nguyen, Thanh Chien; Munief, Walid; Lü, Xiaoling; Pachauri, Vivek; Susloparova, Anna; Vu, Xuan Thang; Ingebrandt, Sven

doi:10.1016/j.bios.2016.09.047

Cited by 63 publications

(50 citation statements)

References 35 publications

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“…Here, a 100 mV peak to peak sine wave oscillation is applied on the gate bias. A 3 dB cut‐off frequency of ≈1200 Hz is obtained for our flexible device (see Figure a), similar or even outperforming the results received for SiO 2 ‐based OECT devices . In addition, a rectangular pulse signal with an amplitude of Δ V GS = 1 mV at a frequency of 1 Hz was coupled to the gate source bias.…”

Section: Resultssupporting

confidence: 84%

High Performance Flexible Organic Electrochemical Transistors for Monitoring Cardiac Action Potential

Liang

Ernst

Brings

et al. 2018

Adv Healthcare Materials

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Flexible and transparent electronic devices possess crucial advantages over conventional silicon based systems for bioelectronic applications since they are able to adapt to nonplanar surfaces, cause less chronic immunoreactivity, and facilitate easy optical inspection. Here, organic electrochemical transistors (OECTs) are embedded in a flexible matrix of polyimide to record cardiac action potentials. The wafer-scale fabricated devices exhibit transconductances (12 mS V ) and drain-source on-to-off current ratios (≈10 ) comparable to state of the art nonflexible and superior to other reported flexible OECTs. The transfer characteristics of the devices are preserved even after experiencing extremely high bending strain and harsh crumpling. A sub-micrometer poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) layer results in a fast transport of ions between the electrolyte and the polymer channel characterized by a cut-off frequency of 1200 Hz. Excellent device performance is proved by mapping the propagation of cardiac action potentials with high signal-to-noise ratio. These results demonstrate that the electrical performance of flexible OECTs can compete with hard-material-based OECTs and thus potentially be used for in vivo applications.

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Section: Resultssupporting

confidence: 84%

High Performance Flexible Organic Electrochemical Transistors for Monitoring Cardiac Action Potential

Liang

Ernst

Brings

et al. 2018

Adv Healthcare Materials

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“…This attribute renders OECTs ideal for interfacing electronics with biological systems, which make use of ionic and biochemical currents and gradients for signalling. 1,2 To date, OECTs have demonstrated their utility for molecular sensing, [3][4][5] cell culture analysis, [6][7][8][9] medical diagnostics, 10,11 neuromorphic computing, 12,13 digital logic circuits, 14 and printed electronics [15][16][17] on a variety of substrates including soft, low-cost, transparent, and conformable materials. 18 Until very recently, however, only p-type conducting and semiconducting polymers have been investigated as channel materials, which has severely hampered the development of the OECT technology.…”

Section: Introductionmentioning

confidence: 99%

n-Type organic electrochemical transistors: materials and challenges

et al. 2018

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“…IDEs facilitate a significant increase of the channel width and consequently also the W / L ch ratio in comparison to conventional architectures without increasing the device area and its overall capacitance . Hempel et al reported on the fabrication of large area (200 µm × 200 µm) OECTs with interdigitated electrode arrays and their utilization for sensing of clusters of cardiac cells. However, a further reduction of the device area is required to facilitate recording action potentials from individual cells.…”

Section: Introductionmentioning

confidence: 99%

Tuning Channel Architecture of Interdigitated Organic Electrochemical Transistors for Recording the Action Potentials of Electrogenic Cells

Liang

Brings

Maybeck

et al. 2019

Adv Funct Materials

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Organic electrochemical transistors (OECTs) have emerged as versatile electrophysiological sensors due to their high transconductance, biocompatibility, and transparent channel material. High maximum transconductances are demonstrated facilitating the extracellular recording of signals from electrogenic cells. However, this requires large channel dimensions and thick polymer films. These large channel dimensions lead to low transistor densities. Here, interdigitated OECTs (iOECTs) are introduced, which feature high transconductances at small device areas. A superior device performance is achieved by systematically optimizing the electrode layout regarding channel length, number of electrode fingers and electrode width. Interestingly, the maximum transconductance (g max ) does not straightforwardly scale with the channel width-to-length ratio, which is different from planar OECTs. This deviation is caused by the dominating influence of the source-drain series resistance R sd for short channel devices. Of note, there is a critical channel length (15 µm) above which the channel resistance R ch becomes dominant and the device characteristics converge toward those of planar OECTs. Design rules for engineering the performance of iOECTs are proposed and tested by recording action potentials of cardiomyocyte-like HL-1 cells with high signal-to-noise ratios. These results demonstrate that interdigitated OECTs meet two requirements of bioelectronic applications, namely, high device performance and small channel dimensions.

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PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Cited by 63 publications

References 35 publications

High Performance Flexible Organic Electrochemical Transistors for Monitoring Cardiac Action Potential

High Performance Flexible Organic Electrochemical Transistors for Monitoring Cardiac Action Potential

n-Type organic electrochemical transistors: materials and challenges

Tuning Channel Architecture of Interdigitated Organic Electrochemical Transistors for Recording the Action Potentials of Electrogenic Cells

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