Localized Periorbital Edema Induced by Ibuprofen

Abstract

We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria. The reaction developed one hour after ingestion of 200 mg of ibuprofen. No systemic symptoms were observed. No other NSAIDs did not induce symptoms. This patient was able to tolerate doses of ibuprofen after pretreatment with terfenadine. These observations suggest that histamine played a central role in this ibuprofen-induced skin reaction. Treatment with terfenadine enabled the patient to tolerate ibuprofen without experiencing any side effects. To the best of our knowledge, this is the first reported case of periorbital edema induced by ibuprofen.

Periorbital edema associated with separate courses of ibuprofen and naproxen

“…Our case most parallels that of the patient described by Palungwachira et al 17 and, to an extent, that of Rafiq, 16 both in the chronological sequence and the type of reaction that occurred. The reaction in these cases began unilaterally and eventually progressed bilaterally.…”

“…Palungwachira et al 17 described a 29-year-old Thai woman receiving no concurrent medications who developed periorbital edema one hour after ingestion of ibuprofen 200 mg orally for tension headache. The adverse reaction began in the leftupper-eyelid region and progressed to both periorbital regions.…”

“…13 A review of the literature identified five case reports of periorbital edema associated with nonsteroidal antiinflammatory drugs (NSAIDs) (aspirin, [14][15][16] ibuprofen, 17 and naproxen 18 ) and one controlled trial on the topic. 19 We describe the Purpose.…”

Mianserin induced periorbital edema: a case report

“…In this view, all etiological factors should be under account to solve this disturbing symptom by the physicians [7,8]. The some medications associated with periorbital edema such as aspirin, naproxen, ibuprofen, nifedipine, diltiazem, midazolam, topiramate, irbesartan, lamotrigine, niacin, omeprazole, pantoprazole, diltiazem, nifedipine, phenytoin, phenobarbital, hydrochlorothiazide, imanitib and risperidone previously had been reported [10][11][12][13]. In some previous case report, peripheral edema associated with mirtazapine was declared [14,15].…”

Periorbital edema

“…One patient had dependent edema after a craniotomy for a brain tumor. Medications associated with periorbital edema Clozapine [101] Hyaluronidase [97,108] Sulfite [105] Pemetrexed [109] Zoledronic acid [95] Diltiazem [110] Risperidone [100,111] Aspirin [99,112,113] Doxorubicin [107] Imatinib [93,94,[114][115][116] Irbesartan [103] Atracurium [117] Ibuprofen [98,118,119] Epoxy resin [120] Nifedipine [102] Naproxen [98] Lamotrigine [104] Cisplatin [106] Ethosuximide [106] Fluorouracil [106] Hydralazine [106] Metformin [106] Methotrexate [106] Methsuximide [106] Oprelvekin [106] Pioglitazone [106] Rifampicin [106] Rosiglitazone [106] Smallpox vaccine [106] Sulfacetamide [106] Sulfafurazole [106] Sulfamethizole [106] Sulfanilamide [106] Sulfasalazine [106] Sulfathiazole [106] Topiram...…”