“…In patients with paraneoplastic hypoglycemia, there are abnormally high levels of a high-molecular-weight IGF-II (big IGF-II) in the tumor and serum. The big IGF-II, incompletely processed pro-IGF-II, could be related to hypoglycemia in the non-islet cell tumor hypoglycemia, because serum big IGF-II is significantly decreased, and hypoglycemia disappears after the removal of tumor [1,2,3,4,5,6,7,8,9]. The mechanism by which big IGF-II produces hypoglycemia remains unclear [8].…”