Localized Primary Amyloidosis of the Genitourinary Tract: Does Conservatism Help?

Zaman, Waheed; Singh, Vishwajeet; Kumar, Binay; Mandhani, Anil; Srivastava, Aneesh; Kumar, Anant; Kapoor, Rakesh

doi:10.1159/000080843

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Typically, in localized amyloidosis of the bladder, amyloid deposits are demonstrated in the lamina propria and muscular is propria with vessel wall involvement. Similar findings were also seen in our patient (8). Some studies have found anti-inflammatory agents such as oral colchicine to be beneficial in the focal bladder amyloidosis while diffuse or locally extensive bladder involvement usually requires conventional transurethral resection that should be supplemented with intravesical dimethyl sulfoxide (DMSO) instillation with periodic cystoscopy (9, 10).…”

Section: Discussionsupporting

confidence: 92%

Primary Localized Amyloidosis of Urinary Bladder: A Case Report and Review of Literature

et al. 2013

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Amyloidosis is a disorder of protein metabolism characterized by extracellular deposition of abnormal protein fibrils. It may either be localized to any organ or systematically distributed throughout the body. The biochemical nature of proteins varies but the physical and tinctorial properties are shared by all the amyloidogenic proteins. In the West, it is mainly composed of amyloid light (AL) type immunoglobulin (Ig) light chains. Amyloidosis of the genitourinary tract is rare except for the kidney and isolated primary amyloidosis of the urinary bladder is even rarer. It mainly presents as intermittent painless gross hematuria. It mimics transitional cell carcinoma on imaging and endoscopic examination. We herein present a case of fifty six-years-old male with history of painless hematuria for three months. Cystoscopy revealed a 1 cm hyperemic area on the posterior wall of urinary bladder. The biopsy showed features of amyloidosis and amyloid A (AA) immunostaining was negative. Extensive workup was done to exclude other sites of involvement and a final diagnosis of primary localized amyloidosis of the urinary bladder was made. The patient is on regular follow-up.

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Section: Discussionsupporting

confidence: 92%

Primary Localized Amyloidosis of Urinary Bladder: A Case Report and Review of Literature

et al. 2013

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“… 9 In another series, four patients with bladder amyloidosis treated with transurethral resection alone achieved a satisfactory outcome. 11 Thus, DMSO perfusion is not as important as once thought.…”

Section: Discussionmentioning

confidence: 97%

Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

Jia

Liu

2020

J Int Med Res

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We herein present a case involving a 23-year-old woman with gross hematuria. Cystoscopy revealed abnormal areas of the mucosa along the anterior and posterior bladder walls. These abnormalities were suspicious for neoplasia; however, a diagnosis was not established by subsequent biopsy. The patient underwent transurethral resection biopsy in which an isolated lesion along the anterior wall was completely resected and the others were left untreated. Pathologic examination and special staining led to a diagnosis of amyloidosis, and the patient elected to undergo transurethral surgery 1 month later. During the operation, the intravesical lesions were found to have significantly improved in both the treated and untreated sites. The operation was cancelled, follow-up was arranged, and no other treatment was administered. Repeat cystoscopy examinations at 3 and 9 months after surgery showed that the lesions had almost completely disappeared.

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“…Management of primary amyloidosis is mainly TURBT with symptomatic therapy if it is localized. [4] Adjuvant intravesical dimethyl sulfoxide therapy has been useful in selected patients with intractable hematuria. [5] However, follow up periodic cystoscopy is mandatory.…”

Section: Discussionmentioning

confidence: 99%

Primary amyloidosis with high grade transitional cell carcinoma of bladder: A rare case report

2012

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Primary amyloidosis of bladder is a rare disease that closely resembles bladder cancer on clinical presentation with painless gross hematuria. Pathologically this is a totally benign non-neoplastic lesion and its association with urothelial carcinoma of the bladder is rare. We herein report a 64-year-old diabetic male who has been treated for primary amyloidosis of bladder for the last 26 years presented recently with high-grade solid urothelial cancer with osseous metaplasia and sarcomatoid change of bladder with area of amyloid deposition.

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Localized Primary Amyloidosis of the Genitourinary Tract: Does Conservatism Help?

Cited by 9 publications

References 17 publications

Primary Localized Amyloidosis of Urinary Bladder: A Case Report and Review of Literature

Primary Localized Amyloidosis of Urinary Bladder: A Case Report and Review of Literature

Spontaneous remission of untreated primary amyloidosis of the bladder after transurethral resection biopsy: a case report and literature review

Primary amyloidosis with high grade transitional cell carcinoma of bladder: A rare case report

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