Primary amyloidosis with high grade transitional cell carcinoma of bladder: A rare case report

Abstract

Primary amyloidosis of bladder is a rare disease that closely resembles bladder cancer on clinical presentation with painless gross hematuria. Pathologically this is a totally benign non-neoplastic lesion and its association with urothelial carcinoma of the bladder is rare. We herein report a 64-year-old diabetic male who has been treated for primary amyloidosis of bladder for the last 26 years presented recently with high-grade solid urothelial cancer with osseous metaplasia and sarcomatoid change of bladder with area of amyloid deposition.

Amyloidosis in the bladder: Three cases with different appearance

“…In some patients cystectomy is necessary owing to irritative symptoms or gross haematuria [4]. Instillation with dimethyl sulfoxide therapy has also been successful [5].…”

“…It is a rare condition, with approximately 200 cases reported in the literature [4]. To the authors' knowledge, there have been only three prior cases with coexisting transitional cell carcinoma (TCC) and amyloidosis in the bladder [5]. This report presents three cases of amyloidosis in the bladder, of which two coexisted with TCC.…”

Osseous Metaplasia of the Urinary Bladder:Mini Review of the Cases Reported After 1991

“…A series of 11 case reports matching our criteria were gathered (Table 1), available to be discussed [2,[4][5][6][7][8][9][10][11][12][13]. Our search was limited concerning the time period, beginning in 1991, as Eble and Young in that year published a review of the literature.…”

A Rare Case of Hematuria; Primary Amyloidosis of the Bladder Neck

“…Evidence suggests that the majority of reported cases of primary urinary bladder amyloidosis manifest as solitary, localized polypoidal lesions 2, 3. However some studies have shown these amyloid lesions may become disseminated and progress even leading to upper urinary tract obstruction 4 . This warrants long-term follow-up, typically in the form of flexible cystoscopic surveillance in cases with primary bladder amyloidosis.…”