Amyloidosis in the bladder: Three cases with different appearance

Schou-Jensen, Katrine; Dahl, Claus; Pilt, Anette Pedersen; Azawi, Nessn

doi:10.3109/21681805.2014.920414

Cited by 4 publications

(11 citation statements)

References 5 publications

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“…It is also reported, albeit rarely, in patients with systemic primary (AL) or secondary (AA) amyloidosis which can affect the bladder and can manifest itself as macroscopic hematuria, bladder hematoma, or bladder perforation. 2,3 We presented two cases of spontaneous massive bladder hematoma in the late period after the transplantation in kidney recipients with systemic AA amiloidosis.…”

Section: Case Reportmentioning

confidence: 99%

Spontaneous Massive Bladder Hematoma in the Late Period After Kidney Transplantation in Patients with AA Amyloidosis: Two Cases

Sadioğlu¹,

Kumru²,

Sendogan³

et al. 2020

Turkiye Klinikleri J Case Rep

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ABS TRACT Massive bladder hematoma can occur following a trauma, neoplastic states, or as a longterm side effect of a pelvic irradiation therapy. It is reported, albeit rarely, in the patients with amyloidosis which can affect bladder and can manifest itself as hematoma. However, it hasn't been yet reported in kidney transplant recipients. A 31 year-old male with chronic glomerulonephritis received kidney transplantation. He developed proteinuria and frequent episodes of lung infection because of bronchiectasis after seven years from transplantation. Duodenal biopsies showed AA-amyloidosis. Macroscopic hematuria appeared, and cystoscopy revealed hematoma and perforation of bladder wall. A 56 year-old male with secondary amyloidosis due to familial Mediterranean fever had kidney transplantation. After two years, cystoscopy was performed because of macroscopic hematuria and revealed large hematoma that completely filled the bladder. To our knowledge, these are the very first cases with AA amyloidosis who developed spontaneous bladder hematoma in kidney transplant recipients.

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Section: Case Reportmentioning

confidence: 99%

Spontaneous Massive Bladder Hematoma in the Late Period After Kidney Transplantation in Patients with AA Amyloidosis: Two Cases

Sadioğlu¹,

Kumru²,

Sendogan³

et al. 2020

Turkiye Klinikleri J Case Rep

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“…Amyloidosis is classified as primary amyloidosis (AL), secondary amyloidosis (AA) and transthyretin-related amyloidosis (ATTR) (9,10,11). Amyloidosis can be either localized or systemic (9,10,11).…”

Section: Cystoscopic Examination Of Bladder Amyloidosis Often Shows Ymentioning

confidence: 99%

“…Amyloidosis can be either localized or systemic (9,10,11). Localized deposition of amyloid may occur in any organ in the absence of systemic involvement (12).…”

Section: Cystoscopic Examination Of Bladder Amyloidosis Often Shows Ymentioning

confidence: 99%

Primary Localized Amyloidosis of the Bladder Mimicking Neoplasia

Ekmekçi¹,

Küçük²,

Çakır³

et al. 2018

jus

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A 63-year-old woman was admitted to our hospital with macroscopic hematuria in 2013. On computed tomography, the bladder wall thickness was 2 cm, suspicious for malignancy. Cystoscopy showed irregularity in the posterolateral side of the bladder. Transurethral resection was performed. Histopathological examination revealed a dense homogeneous eosinophilic material in the lamina propria which showed positive orange-red staining with apple-green birefringence under polarized light. There were no signs of systemic amyloidosis at the time of diagnosis and during the 36 months of follow-up. Differential diagnosis of amyloidosis in the bladder includes urothelial carcinoma due to its appearance on imaging and cystoscopy. Histopathological evaluation is a requirement for accurate diagnosis. Keywords: Primary, Amyloidosis, Bladder Altmış üç yaşında kadın hasta 2013 yılında makroskopik hematüri ile hastanemize başvurdu. Bilgisayarlı tomografide, mesane duvarının posterolateral ve superior kısmının, tümör açısından şüphe uyandıracak şekilde 2 cm kalınlığında olduğu görüldü. Sistoskopik bakıda mesanenin posterolateral tarafında düzensiz alanlar görüldü. Transüretral mesane rezeksiyonu ile kürete materyal elde edildi. Biyopside lamina propriada turuncu-kırmızı boyanma gösteren, yoğun, homojen eozinofilik materyal izlendi ve polarizasyonda elma yeşili çift kırılımı gösterildi. Olguda tanı anında ve 36 aylık takiplerinde sistemik amiloidoz bulguları saptanmadı. Mesanenin amiloidozu, görüntüleme yöntemlerinde ve sistoskopide ürotelyal karsinom ile kolayca karışabilen nadir bir durumdur. Kesin tanı için histopatolojik inceleme şarttır.

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“…63,64 Patients typically present with grossly painless hematuria and lower urinary tract symptoms in the fifth to seventh decades of life with an equal sex distribution. [63][64][65][66][67][68] The diagnosis is difficult to make by cytologic examination of urine specimens because deposition within the bladder wall shows poor correlation with precipitation in urine. 64,66,68. The most common subtype of amyloid involving the bladder is amyloid light chain (AL), with conflicting reports on the predominant light chain (k versus j).…”

Section: Amyloidosis Of the Genitourinary Tractmentioning

confidence: 99%

“…A few cases of ATTR (transthyretin) have also been reported; however, none of those cases had been confirmed/ characterized by mass spectrometry. 67 Less commonly, amyloidosis is seen in the glans penis. Approximately 12 cases have been reported in the literature, with the common presentation of asymptomatic, nodular, tan/ yellow, and rubbery deposits on the skin of the penis.…”

Section: Amyloidosis Of the Genitourinary Tractmentioning

confidence: 99%

Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging

Ellis

Harik

Cohen

et al. 2017

Archives of Pathology &Amp; Laboratory Medicine

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Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. We illustrate applications of immunohistochemistry for differential diagnosis of needle core renal biopsies, intraductal carcinoma of the prostate, and amyloidosis and cite encouraging results from early studies using targeted gene expression panels to predict recurrence after prostate cancer surgery. At our institution, pathologists are working closely with urologic surgeons and interventional radiologists to explore the use of intraoperative frozen sections for margins and nerve sparing during robotic prostatectomy, to pioneer minimally invasive videoscopic inguinal lymphadenectomy, and to refine image-guided needle core biopsies and cryotherapy of prostate cancer as well as blue-light/fluorescence cystoscopy. This collaborative, multidisciplinary approach enhances clinical management and research, and optimizes the care of patients with urologic disorders. (Arch Pathol Lab Med. 2017;141:499-516; doi: 10.5858.arpa.2016-0263-SA) I n this review, we summarize the effect of a number of biomarker, molecular, and technologic advances in urologic pathology, oncology, and imaging on routine, day-to-day practice and research at our institution. The objective of this review is not to cover the entire gamut of all advances that we have and use at our institution but, rather, to highlight a few pertinent concepts in our field. Topics that will be covered include biomarkers, molecular testing of selected malignancies (eg, transcription factor E3 [TFE3]/ Xp11.2 translocation-associated renal cell carcinoma; p63, high-molecular-weight cytokeratin and racemase cocktail [PIN4]/phosphatase and tensin homolog [PTEN] for some cases of intraductal carcinoma of the prostate; and succinate dehydrogenase subunit B in renal cell carcinoma and pheochromocytoma), amyloidosis of the genitourinary tract, and workup of neoplastic needle core kidney biopsies. In addition, we will report the effect of pathologic, oncologic, and radiologic technologic advances (ie, global transcriptome analysis and RNA biomarkers of prostate cancer; robotic-assisted radical prostatectomy; minimally invasive videoscopic inguinal lymphadenectomy; targeted magnetic resonance imaging [MRI]-guided prostate needle core biopsies; anti-1-amino-3-fluorine 18-fluorocyclobutane-1-carboxylic acid in prostate cancer; cryotherapy for prostate cancer; and blue-light/white-light cystoscopy for bladder lesions) performed at our institution.

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Amyloidosis in the bladder: Three cases with different appearance

Cited by 4 publications

References 5 publications

Spontaneous Massive Bladder Hematoma in the Late Period After Kidney Transplantation in Patients with AA Amyloidosis: Two Cases

Spontaneous Massive Bladder Hematoma in the Late Period After Kidney Transplantation in Patients with AA Amyloidosis: Two Cases

Primary Localized Amyloidosis of the Bladder Mimicking Neoplasia

Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging

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