Localized Surface Plasmon Resonance Biosensors

Abstract

In this review, the most recent progress in the development of noble metal nano-optical sensors based on localized surface plasmon resonance (LSPR) spectroscopy is summarized. The sensing principle relies on the LSPR spectral shifts caused by the surrounding dielectric environmental change in a binding event. Nanosphere lithography, an inexpensive and simple nanofabrication technique, has been used to fabricate the nanoparticles as the LSPR sensing platforms. As an example of the biosensing applications, the LSPR detection for a biomarker of Alzheimer's disease, amyloid-derived diffusable ligands, in human brain extract and cerebrospinal fluid samples is highlighted. Furthermore, the LSPR sensing method can be modified easily and used in a variety of applications. More specifically, a LSPR chip capable of multiplex sensing, a combined electrochemical and LSPR protocol and a fabrication method of solution-phase nanotriangles are presented here.

A Novel Silver Nanoparticles-based Sensing Probe for the Detection of Japanese Encephalitis Virus Antigen

“…These nanoparticles possess strong absorption properties in the visible region, often known as the localized surface plasmon resonance. Surface plasmon resonance happens when the incident photon frequencies are resonant with the collective oscillations of conduction electrons of the metal nanomaterials (Zhao et al 2006). Among noble metal nanomaterials, silver nanoparticles (Ag NPs) have received considerable attention due to their attractive physico-chemical properties.…”

CHCA-modified Au nanoparticles for laser desorption ionization mass spectrometric analysis of peptides

“…Gold nanoparticles (AuNPs), which display strong surface plasmon absorption properties, have been utilized in various analytical techniques, including biological optical imaging, biosensing, and surface-enhanced Raman spectroscopy [11][12][13]. Their potential in SALDI-MS has been recognized in recent years.…”

Investigation of plasmon resonance tunneling through subwavelength hole arrays in highly doped conductive ZnO films

“…14 The achieved layer was nominally Zn 0.974 Ga 0.026 O with a doping level of $10 21 cm À3 as measured by IR ellipsometry. 26 The layer thickness was measured to be $1.2 lm with an uncertainty of 671 nm using visible ellipsometry.…”

“…The investigation of alternative plasmonic materials has recently been accelerated 7,[14][15][16][17][18][19][20][21][22][23][24][25][26] due to the push to the infrared where noble metals are not as useful due to weak mode confinement and lack of CMOS compatibility. Two promising candidates, aluminum and gallium doped ZnO, have been proposed as possible plasmonic materials in the near- 17,19 and mid-IR 26 as these materials typically demonstrate plasma wavelengths $1 lm.…”