Locally Aggressive Giant Cell Tumor of Bone With Pulmonary Distant Metastasis and Extrapulmonary Seeding in Pregnancy

Murshed, Khaled; Elsayed, Ahmed Mounir; Szabados, Lajos; Rashid, Sameera; Ammar, Adham

doi:10.5435/jaaosglobal-d-19-00161

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Compared with regional tumors (31.8%), patients with distant metastatic tumors (16.2%) had a poorer prognosis. Similarly, numerous studies have also found that distant metastasis was also related to poor prognosis [ 8 , 17 , 18 ]. It not only increased the tumor burden and damaged organ function, but also limited the application of the en bloc tumor resection [ 1 ].…”

Section: Discussionmentioning

confidence: 98%

Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population

Zhu

Huang

et al. 2020

Med Sci Monit

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Background Malignant giant cell tumor of bone (MGCTB) is a rare histological type of malignant tumor that has a high tendency for local relapse and distant metastasis and ultimately leads to a poor prognosis. The purpose of this study was to describe the epidemiological features, identify the prognostic factors, and construct nomograms for patients with MGCTB. Material/Methods Patients with MGCTB that was histologically diagnosed between 1973 and 2014 were selected from the Surveillance, Epidemiology, and End Results (SEER) database as a training set. Survival analysis, Lasso regression, and random forests were used to identify the prognostic variables and establish the nomograms for patients with MGCTB, while an external cohort of 37 patients from our own institution and an external cohort of 163 patients from the SEER database in 2016 were used to validate the generalization performance of the nomograms. Results In total, univariate and multivariable analysis indicated that age, International Classification of Diseases for Oncology, historical stage, primary site, surgery information, radiotherapy, and chemotherapy were independent prognostic variables for overall survival or cause-specific survival. Nomograms based on the multivariable models were built to predict survival, and we achieved a higher C-index in subsequent multidimensional validation. Conclusions Age, historical stage, and chemotherapy were independent prognostic variables for overall survival and cause-specific survival of MGCTB patients, and radiotherapy and primary site were independent prognostic variables for overall survival. Nomograms based on significant clinicopathological features and clinical experience can be effective in predicting the probability of survival for MGCTB patients.

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Section: Discussionmentioning

confidence: 98%

Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population

Zhu

Huang

et al. 2020

Med Sci Monit

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“…It is also reported that these tumours behave more aggressively during pregnancy as these lesions may be hormonally regulated. The GCT may express ER or PR, and elevated levels of these hormones could potentially influence the tumour cells 7 8. It is proposed that the aggressive nature of such lesions could be due to the resemblance of the oncofetal antigens of tumour cells with the fetal antigens 9.…”

Section: Discussionmentioning

confidence: 99%

Aggressive giant cell tumour (GCT) of the distal humerus in a young pregnant woman

et al. 2022

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A 25-year-old pregnant woman reported suffering from an aggressive giant cell tumour of the distal humerus extending into the elbow joint. The successful management required a careful evaluation of the various treatment options due to her pregnancy. Surgical excision of the mass was performed. The residual bone defect was reconstructed with an elbow mega-prosthesis. The patient made a pain-free recovery with a good range of motion and delivered the baby at term with no complications.

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Giant Cell Tumor

Bahk

2023

Diagnosis and Management of Primary Bone Tumors

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Locally Aggressive Giant Cell Tumor of Bone With Pulmonary Distant Metastasis and Extrapulmonary Seeding in Pregnancy

Cited by 5 publications

References 12 publications

Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population

Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population

Aggressive giant cell tumour (GCT) of the distal humerus in a young pregnant woman

Giant Cell Tumor

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