Pseudomyogenic hemangioendothelioma (PMHE) is an uncommon vascular neoplasm of intermediate malignant potential that rarely arises in bone. SERPINE1-FOSB fusion gene occurs frequently in PMHE of bone; however, WWTR1-FOSB fusion gene is rarely reported. The prognostic and therapeutic significance of these gene rearrangements is unclear and needs to be investigated further. Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm of intermediate malignant potential that usually arises in the soft tissues of the lower and upper extremities. 1-4 Its occurrence in bone is a rare event. To the best of our knowledge, only 27 cases of primary PMHE of bone have been reported so far 4-17 (Table 1). Few of those reported cases were found to harbor the balanced translocation t(7;19)(q22;q13) producing fusion between SERPINE1 and FOSB genes, 10,12 and only one case was found to carry WWTR1-FOSB fusion gene. 17 Herein, we present the second case of primary PMHE of bone with WWTR1-FOSB fusion gene. 2 | CASE PRESENTATION A previously healthy 7-year-old girl presented to the clinic with intermittent pain of the right thigh for two-year duration. The pain was more severe at night. It was not associated with fever, weight loss, or other constitutional symptoms. Analgesics were given initially which relieved her symptoms temporarily; however, she started to feel pain at her right knee after an accident of falling. X-ray was performed, which revealed a well-demarcated radiolucent lytic lesion arising from the metaphysis of the right distal femur with cortical thinning. However, no periosteal reaction or soft tissue involvement was identified (Figure 1). A needle core

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The Amazon of the 21 st century, with its rich biodiversity and culture of traditional peoples, has in recent decades suffered severe deforestation, which today coincide with the tragic pandemic by COVID-19 that we experienced. The interaction between these two processes, deforestation of primary forests and COVID19 on traditional populations in the Amazon Biome threatens not only the future of the next generations, but also the future of Ethnopharmacology and Ethnophytomedicine that has in the traditional knowledge of indigenous peoples and afro-descendants (quilombolas) about medicinal plants, its basis for the development of new biomedical technologies and new drugs. Considering the potential of the Amazon forest regarding the diversity of medicinal plants pointed out by numerous ethnobotanical research [1-5], then it is to be expected that the disturbances in the floristic composition and richness of these environments drastically affect the survival of traditional populations living in remote areas, away from hospitals, as it has in the forest, their cure [6]. Unfortunately, such disturbances already happen as demonstrated by the data of the National Institute of Space Research [7] which observed an