In this paper we aim at presenting a concise but also comprehensive study of time-dependent (tdependent) Hamiltonian dynamics on a locally conformal symplectic (lcs) manifold. We present a generalized geometric theory of canonical transformations and formulate a time-dependent geometric Hamilton-Jacobi theory on lcs manifolds. In contrast to previous papers concerning locally conformal symplectic manifolds, here the introduction of the time dependency brings out interesting geometric properties, as it is the introduction of contact geometry in locally symplectic patches. To conclude, we show examples of the applications of our formalism, in particular, we present systems of differential equations with time-dependent parameters, which admit different physical interpretations as we shall point out.