Locally invasive and obstructive colonic leiomyosarcoma: a diagnostic and therapeutic challenge

Wong, Yon-Cheong; Chan, Shirley; Yuen, KY; Chong, Li Chia

doi:10.12809/hkmj197873

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Adenocarcinoma and lymphoma can readily be differentiated from PLC on microscopic examination. 8 PLC tumor cells are usually spindle-shaped and arranged in perpendicular fascicles. They have eosinophilic cytoplasm and cigar-shaped nuclei with blunted ends.…”

Section: Discussionmentioning

confidence: 99%

“…9 However, PLC, GIST, kaposi sarcoma, and schwannoma share resemblance in histological appearance, so immunohistochemistry is needed to distinguish them apart. 8 PLC express smooth muscle actin, desmin, and caldesmon but do not express GIST markers (CD34, CD117, and DOG-1), S100 (differentiating it from schwannoma), or HHV8 (differentiating it from Kaposi sarcoma). [9][10][11] PLC are known to be more aggressive with poorer prognoses than other tumors of the colon.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve

2021

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Primary leiomyosarcomas of the colon (PLC) are rare tumors, representing 0.12% of all colon malignancies. We report a 59-year-old man with weight loss, mild anemia, and rectal bleeding. Colonoscopy revealed a 3.2 × 2.6-cm mass at the ileocecal valve. Histopathological examination of the biopsy showed a spindle cell neoplasm that stained positive for smooth muscle actin, caldesmon, and desmin. A diagnosis of PLC was made. Subsequently, a laparoscopic right hemicolectomy was performed, and no local recurrence was noted 6 months after the resection. Given the rarity of PLC, more studies on the clinical features and treatments of this tumor are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve

2021

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“…As stated by Sert et al, a GIST diagnosis should be immunohistochemically confirmed, CD117 and DOG1 being positive in up to 95% of cases [21]. Less sensitive and specific, CD34 is also expressed in these tumors, other markers positive in a significant number of cases being represented by PDGFRA (a tyrosine kinase mutually exclusive with CD117), H-caldesmon, SMA, S100 or Desmin [30,31,32,33]. The immunophenotype of the tumors we have studied presented no particularities, being in accordance with the published data.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumors of the colon and rectum

Roşulescu

Pechianu

Hortopan

et al. 2020

pjp

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Gastrointestinal stromal tumors (GISTs) are rare neoplasms, colorectal location being met in less than 5% of cases. Knowledge about this site related particularities are limited. The aim of this study is to present our experience with colorectal GISTs between 2005 and 2018 from the clinical, morphological, and immunohistochemical perspectives, with emphasis on prognostic factors. From a total of 203 gastrointestinal stromal tumors registered, 12 were colorectal (6%). The number of colonic tumors surpassed that of the rectum (9 : 3) and on the right side were registered more cases than on the left side (6/3). 9 were primary tumors and 3 were recurrences. Men and women were represented equally and the age range was between 22 and 76. Tumor dimensions varied between 0.5 and 14 cm. Microscopically, spindle cell type was dominant. Mitotic rate was variable between 1 and 115/50HPFs. Accordingly, for primary tumors progression risks were assigned (low risk: 2 cases, intermediate risk: 3 cases and high risk: 4 cases). All GISTs were CD117 and DOG1 positive. Four of the patients died of the disease.

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“…Tubulin inhibitors, such as Vinca alkaloids, taxanes, and eribulin, are widely used as anticancer agents [ 20 , 21 ]. Notably, Ginsenoside Rb1 (Rb1), derived from Ginseng, has showed promising antitumor and anti-inflammatory effects in various types of tumors [ [22] , [23] , [24] ]. However, the efficacy of most anticancer drugs varies across different cancer types due to diverse micro-environments and individual heterogeneity [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of thiophene derivatives as dual inhibitors of β-tubulin and Wnt/β-catenin pathways for gastrointestinal cancers in vitro

Fu,

Li,

Xue

et al. 2024

Heliyon

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Locally invasive and obstructive colonic leiomyosarcoma: a diagnostic and therapeutic challenge

Cited by 5 publications

References 8 publications

Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve

Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve

Gastrointestinal stromal tumors of the colon and rectum

Exploring the potential of thiophene derivatives as dual inhibitors of β-tubulin and Wnt/β-catenin pathways for gastrointestinal cancers in vitro

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