Locally Transplanted CD34+ Bone Marrow–Derived Cells Contribute to Vascular Healing After Vascular Injury

Ananthaseshan, Sharan; Grudzińska, M; Bojakowski, Krzysztof; Kurzejamska, Ewa; Gaciong, Zbigniew; Söderberg‐Nauclér, Cecilia; Religa, Piotr

doi:10.1016/j.transproceed.2017.01.081

Cited by 8 publications

(12 citation statements)

References 23 publications

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“…Due to their potential vasculo-reparative capacities, clinical studies have been undertaken to assess their efficacy as cellular therapies to promote recovery of blood flow in myocardial infarction and stroke studies. Clinical studies showing implantation or injection of these cell types show promise in repair of damaged myocardium in animal models 2 and in some human studies 22, 23 , however due to the expense and research and development required to optimize this cellular therapy, other non-pharmaceutical interventions may be more effective in promoting endogenous vascular repair for clinical benefit. In addition given the reduced number and function of these cells in CVD 5 , and the predictive association with mortality, it is pertinent to find therapies to augment production, mobilization and function of these cells.…”

Section: Discussionmentioning

confidence: 99%

“…Circulating progenitor cells (CPC) are a heterogenous group of cells which have tissue regenerative potential. A number of studies have shown that CD34 + CPCs and several subsets of CD34 + cells (such as CD34 + CD133 + /KDR + ) can participate in vascular repair and growth 1, 2 , and may be associated with vascular endothelial function 3 . Therefore these cells may reflect vascular integrity and have been used as vascular biomarkers of repair 4 .…”

Section: Introductionmentioning

confidence: 99%

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Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Muggeridge

Dodd

Ross

2020

Preprint

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Background: Circulating progenitor cells (CPCs) play an important role in vascular repair and may influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primary aims of this study were to evaluate the association of CPCs with mortality and explore the association between physical activity (PA) and CPCs. Design: We studied 1,751 individuals from the Framingham Offspring cohort (66 ± 9 years [40−92 years], 54% female). CPCs (CD3++, CD34+CD133+, CD34+CD133+KDR+) were measured in participants using flow cytometry. Multivariable cox regression analyses were performed to investigate relationship of CPCs with future CV event, CV mortality and all-cause mortality. Multivariate regression analyses were performed to determine the relationship between self-reported PA and CPC counts. Results: Following adjustment for standard risk factors, there was an inverse association between CD34+ CPCs and all-cause mortality (hazard ratio (HR) per unit increase in CD34+, 0.79; 95% CI 0.64 − 0.98, P=0.036). CD34+CD133+ CPCs were inversely associated with CV mortality (HR 0.63, 95% CI 0.44 − 0.91, P=0.013). Associations of CD34+ and CD34+CD133+ with mortality were strongest in participants with pre-existing CVD. PA was associated with CD34+ CPCs only in CVD participants. This relationship was maintained after adjustment for confounding variables. Conclusions: Higher number of CD34+ and CD34+CD133+ CPCs were inversely associated with all-cause and CV mortality. These associations were strongest in participants already diagnosed with CVD. PA is independently associated with CD34+ CPCs in individuals with CVD only, suggestive of greater benefit for this population group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Muggeridge

Dodd

Ross

2020

Preprint

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“…The recruitment, activation, and proliferation of monocytes/macrophages in the vessel wall may contribute to the process of atherosclerosis and restenosis. The presence of activated monocytes/macrophages at the site of the vascular injury leads to the release of vasoactive molecules, cytokines, chemokines, and growth factors which can induce the migration and proliferation of SMCs [16,33,46]. Macrophages present in atherosclerotic plaque causes instability and increases the incidence of acute ischemic episodes [34].…”

Section: Discussionmentioning

confidence: 99%

“…Polysaccharides constitute a large family of molecules demonstrating the ability for numerous interactions with cellular targets within the arterial wall. Fucoidans are vegetal sulfated polysaccharides extracted from brown seaweed, which are reported to possess properties such as anti-coagulant, anti-thrombotic, anti-inflammatory, anti-tumor, anti-adhesive, and anti-viral activities [3,4,45,46]. Many of these effects are mediated by fucoidan interactions with growth factors such as basic fibroblast growth factor [5] and the transforming growth factor-beta [6].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Inhibits Vascular Remodeling in Transplant Vasculopathy in Rat

Soin¹,

Kurzejamska²,

Gaciong³

et al. 2018

FFHD

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Background: Fucoidan is a natural sulfated polysaccharide which exists mainly in the cell wall matrix of various species of brown seaweed. Various forms of fucoidan have also been recognized in some marine invertebrates such as sea urchins and sea cucumbers.Fucoidan inhibits the spread of cancerous cells by preventing the adhesion of tumor cells to the extracellular matrix in addition to inducing apoptosis, or programmed self-destruction, in human T-cells infected by T-cells leukemia virus type I (HTLV-1) which causes adult T-cell leukemia. The polysaccharide has also been shown to stimulate the phagocytic action of macrophages and synthesis of several immune cell types, which increases protection against infection. Fucoidan gives the immune system a big boost by enhancing phagocytosis. Additionally, it increases the number of mature white blood cells which are circulating in the body, thereby bolstering the first line of defense against infections and diseases.Moreover, fucoidan has anti-coagulant, anti-thrombotic, anti-inflammatory, antioxidant, anti-allergic, anti-tumor properties and also many others.Methods and Results: In this study, we investigated whether fucoidan is able to alleviate the vascular remodeling process triggered by immunological stimuli in rat allogenic aorta transplantation model, in addition to the evaluated potential mechanisms responsible for the observed effects. Our rat aorta transplantation model was subjected to intraperitoneal or oral treatment with fucoidan or placebo. The results of our study demonstrated that fucoidan inhibits endointimal hyperplasia formation and vascular modulation. In particular, intraperitoneal and oral administration of fucoidan reduced neointima formation in allografts retrieved 8 weeks after transplantation. Moreover, both treatments with fucoidan reduced the number of smooth muscle (SM) a-actin positive cells in intima and adventitia, decreased percentage of macrophages in intima and media, and increased the number of leukocytes in media of the allografts. Fucoidan treatments have also caused reduction in apoptosis in allograft intima and media.Conclusion: Through our study, we demonstrated the inhibitory effect of fucoidan on vascular remodeling in transplant vasculopathy within rats. Our study is the first report of the beneficial effects of fucoidan oral administration on this process, which may have important clinical implications and result in a better understanding of vascular remodeling. Keywords: fucoidan, transplant vasculopathy, vascular remodeling

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“…This involves thrombosis, migration and proliferation of vascular cells, matrix production, and inflammatory-cell infiltration. Mechanical injury results in vessel constriction and smaller vascular lumen in response to the scarring in the outer vessel layer [66]. Key features of transplant vasculopathy include inflammation and formation of intimal hyperplasia [62,67,68].…”

Section: Vascular Remodellingmentioning

confidence: 99%

Vascular related pathologies in cardiovascular disease and cancer

Ananthaseshan

Religa

2018

hpc

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Cancer and Cardiovascular diseases (CVD) are the two most prominent causes of death worldwide. Emerging evidence indicates shared risk factors and a common biology between these diseases. For instance, chronic inflammation has a significant role in contributing to both diseases. An alteration of the vasculature and the endothelial cells plays a key role in pathogenesis of CVD and cancer. The widespread overlap regarding disease prevention and risk factors for these diseases suggest a common mechanism in terms of molecular pathways. The goal of this tutorial is to present common problems and mechanism of these two mayor diseases.

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Locally Transplanted CD34+ Bone Marrow–Derived Cells Contribute to Vascular Healing After Vascular Injury

Cited by 8 publications

References 23 publications

Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Fucoidan Inhibits Vascular Remodeling in Transplant Vasculopathy in Rat

Vascular related pathologies in cardiovascular disease and cancer

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Locally Transplanted CD34+ Bone Marrow–Derived Cells Contribute to Vascular Healing After Vascular Injury

Cited by 8 publications

References 23 publications

Circulating CD34+ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Circulating CD34+ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Fucoidan Inhibits Vascular Remodeling in Transplant Vasculopathy in Rat

Vascular related pathologies in cardiovascular disease and cancer

Contact Info

Product

Resources

About

Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

Circulating CD34⁺ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.