Locoregional ablative treatment of melanoma metastases

Putzer, Daniel; Schullian, Peter; Bale, Reto

doi:10.1080/02656736.2019.1647353

Cited by 10 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The hepatotropism of UM contributes to the development of liver-directed therapy methods [105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123] (Table 2, Ref. [28,95,[108][109][110]112,113,115,[118][119][120][121][122][123]). In certain cases, surgical removal of metastatic nodules can offer long-term survival benefit.…”

Section: Liver-directed Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

Liver metastasis in uveal melanoma — treatment options and clinical outcome

Kaštelan¹,

Zimak²,

Ivanković³

et al. 2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults with a stable incidence rate between five and seven cases per million in Europe and the United States. Although UM and melanoma from other sites have the same origin, UM has different epidemiological, biological, pathological and clinical features including characteristic metastatic hepatotropism. Despite improvements in the treatment of primary tumours, approximately 50% of patients with UM will develop metastases. In 90% of cases the liver is the first site of metastasis, however the mechanisms underlying this hepatic tropism have not been elucidated. Metastatic disease is associated with a very poor prognosis with a median overall survival of 6 to 12 months. Currently, there is no standard systemic treatment available for metastatic UM and once liver metastases have developed, prognosis is relatively poor. In order to prolong survival, close follow-up in all patients with UM is recommended for early detection and treatment. The treatment of metastatic UM includes systemic chemotherapy, immunotherapy and molecular targeted therapy. Liver-directed therapies, such as resection, radioembolization, chemoembolization, immunoembolization, isolated and percutaneous liver perfusion as well as thermal ablation represent available treatment options. However, to date a consensus regarding the optimal method of treatment is still lacking and the importance of setting guidelines in the treatment and management of metastatic UM is becoming a priority. Improvement in knowledge and a better insight into tumour biology, immunology and metastatic mechanism may improve current treatment methods and lead to the development of new strategies paving the way for a personalized approach.

show abstract

Section: Liver-directed Therapiesmentioning

confidence: 99%

“…To date there is no standard form of care for patients who develop metastasis. Potential treatment options are surgical resection or other liver directed therapy, chemotherapy, immunotherapy and targeted therapies [2,9,19,20,[25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Liver metastasis in uveal melanoma — treatment options and clinical outcome

Kaštelan¹,

Zimak²,

Ivanković³

et al. 2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

show abstract

“…Hierbei wird der Zelltod von Tumorzellen durch die Anwendung spezieller Elektroden mit kurzen elektrischen hochfrequenten Hochspannungsimpulsen induziert. Diese Technik ist gut geeignet zur Behandlung von Tumoren in der Nähe von Gefäßstrukturen oder zentralen Gallenwegen, da sie nicht durch "heat sink effekt" limitiert ist [16,20].…”

Section: Irreversible Elektroporationunclassified

Interventionelle und chirurgische Therapie non-kolorektaler Lebermetastasen

Kniepeiss

Talakić

Schemmer

2021

TumorDiagnostik & Therapie

View full text Add to dashboard Cite

ZusammenfassungIn der Vergangenheit wurden Resektionen oder Transplantationen wegen non-kolorektaler Lebermetastasen durch die Abwägung von geringem Überlebensvorteil und Komplikationsrate eher zurückhaltend indiziert. Mittlerweile zählt die Leberchirurgie jedoch zu den komplikationsarmen Standardverfahren in der Tumortherapie, die unter Einbettung in multimodale Therapiekonzepte zu einer deutlichen Steigerung des Patientenüberlebens führen.

show abstract

“…In the recent past, conventional US- or CT-guided percutaneous radiofrequency ablation (RFA) techniques have been increasingly applied for the treatment of mainly unresectable primary and secondary liver tumours [ 15 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Aggressive local treatment for recurrent intrahepatic cholangiocarcinoma—Stereotactic radiofrequency ablation as a valuable addition to hepatic resection

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background To evaluate the efficacy, safety and overall clinical outcome of local treatment for recurrent intrahepatic cholangiocellular carcinoma after hepatic resection. Methods Between 2007 and 2019 72 consecutive patients underwent hepatic resection for primary intrahepatic cholangiocellular carcinoma. If amenable, recurrent tumors were aggressively treated by HR or stereotactic radiofrequency ablation with local curative intent. Endpoints consisted of morbidity and mortality, locoregional and de novo recurrence, disease free survival, and overall survival. Results After a median follow-up of 28 months, recurrence of intrahepatic cholangiocellular carcinoma was observed in 43 of 72 patients undergoing hepatic resection (60.3%). 16 patients were subsequently treated by hepatic resection (n = 5) and stereotactic radiofrequency ablation (n = 11) with local curative intention. The remaining 27 patients underwent palliative treatment for first recurrence. Overall survival of patients who underwent repeated aggressive liver-directed therapy was comparable to patients without recurrence (p = 0.938) and was better as compared to patients receiving palliative treatment (p = 0.018). The 5-year overall survival rates for patients without recurrence, the repeated liver-directed treatment group and the palliative treatment group were 54.3%, 47.7% and 12.3%, respectively. By adding stereotactic radiofrequency ablation as an alternative treatment option, the rate of curative re-treatment increased from 11.9% to 37.2%. Conclusion Repeated hepatic resection is often precluded due to patient morbidity or anatomical and functional limitations. Due to the application of stereotactic radiofrequency ablation in case of recurrent intrahepatic cholangiocellular carcinoma, the number of patients treated with curative intent can be increased. This leads to favorable clinical outcome as compared to palliative treatment of intrahepatic cholangiocellular carcinoma recurrence.

show abstract

Locoregional ablative treatment of melanoma metastases

Cited by 10 publications

References 48 publications

Liver metastasis in uveal melanoma — treatment options and clinical outcome

Liver metastasis in uveal melanoma — treatment options and clinical outcome

Interventionelle und chirurgische Therapie non-kolorektaler Lebermetastasen

Aggressive local treatment for recurrent intrahepatic cholangiocarcinoma—Stereotactic radiofrequency ablation as a valuable addition to hepatic resection

Contact Info

Product

Resources

About