Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy

Du, Quan; Fu, Yingxue; Shu, Anmei; Lv, Xing; Chen, Yuping; Gao, Yuyan; Chen, Jing; Wang, Wei; Lv, Gaohong; Lu, Jianhua; Xu, Hao

doi:10.1016/j.lfs.2020.118808

Cited by 47 publications

(25 citation statements)

References 32 publications

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“…[27][28][29] Notably, the role of MCP-1 in driving the direction of macrophage polarization has been controversial in many nonheart disease studies. [30][31][32][33][34][35][36] However, in studies related to cardiovascular disease and heart failure, the role of the MCP-1-CCR2 pathway in promoting M1 polarization and the proinflammatory effect of CCR2 + macrophages have been more widely reported, [37][38][39][40][41][42][43] which is consistent with our experimental results. We speculate that cardiomyocytes may release certain secretory factors that can collaborate with the MCP-1-CCR2 pathway and participate in M1 macrophage polarization.…”

supporting

confidence: 91%

Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension

Guo¹,

Qin²,

Cao³

et al. 2021

JIR

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supporting

confidence: 91%

Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension

Guo¹,

Qin²,

Cao³

et al. 2021

JIR

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“…The activation of these signalling pathways plays a vital role in anti‐apoptosis, angiogenesis, and cell migration, leading to oncogenic advancement. The CCL2‐CCR2 axis is also implicated in the progression of numerous human diseases, such as inflammatory pain, 39 atherosclerosis, 40 neuroinflammatory diseases, 41 rheumatoid arthritis 42 and diabetic nephropathy 43 . Therefore, the CCL2‐CCR2 axis is considered an appealing target for the treatment of these diseases.…”

Section: Biological Characteristics Of the Ccl2‐ccr2 Signalling Axismentioning

confidence: 99%

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

et al. 2021

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The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2‐CCR2 signalling axis function in malignancies. Therapeutic strategies targeting the CCL2‐ CCR2 axis have also shown promising effects, enriching our approaches for fighting against cancer. In this review, we summarize the role of the CCL2‐CCR2 signalling axis in tumorigenesis and highlight recent studies on CCL2‐CCR2 targeted therapy, focusing on preclinical studies and clinical trials.

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“… El-Horany et al (2017) demonstrated that the mRNA levels of NLRP3 and IL-1β were increased in DN patients and were positively correlated with the urinary albumin/creatinine ratio and serum creatinine. The inflammatory cytokines MCP-1 ( Du et al, 2021 ), IL-10 ( Landis et al, 2018 ), and IL-6 ( Qin and Qiu, 2019 ) are also increased in the kidneys of DN patients. These studies suggest that inflammation is activated and involved in DN progression.…”

Section: Introductionmentioning

confidence: 99%

The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response

et al. 2021

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Diabetic nephropathy (DN) is one of the most severe complications of diabetes. Inflammation mediated by inflammatory factors is thought to accelerate the progression of renal damage in DN. However, which inflammatory factors mediate the inflammatory response in DN remains unclear. In this study, we determined that the CXCL1-mediated inflammatory response may play an essential role in DN progression through bioassays. Subsequently, we observed that the expression of CXCL1 and its receptor (CXCR2) was significantly increased in the kidneys of mice with HFD + STZ induced diabetes and DN patients. In addition, inhibition of the CXCL1/CXCR2 axis by repertaxin alleviates renal inflammation and pathological damage in the kidneys of db/db mice. Finally, we noted that the CXCL1/CXCR2 axis might lead to inflammatory damage through phosphorylated NF-κB and further activate the NLRP3 inflammasome. Our results revealed the role of the CXCL1/CXCR2 axis in DN progression for the first time, which may be a novel therapeutic target for DN.

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Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy

Cited by 47 publications

References 32 publications

Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension

Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response

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