Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

Ruskowitz, Emily R.; Comerford, Michael P; Badeau, Barry A; DeForest, Cole A.

doi:10.1039/c8bm01304g

Cited by 37 publications

(20 citation statements)

References 33 publications

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“…In some instances, it can also introduce stimuli-responsive release of drugs, if, for example, the linkages are cleavable by specific environmental factors such as pH or expression of a specific enzyme. 45 Alternatively, light and heat-cleavable linkages open the door to exogenously triggered drug release. 207,208 Overall, these strategies provide significantly more control over the release rate of small molecules, but they do introduce their own complexities.…”

Section: Considerations For Small Molecule Deliverymentioning

confidence: 99%

“…One technique is to tether drugs directly to the hydrogel network, either through irreversible covalent attachment or a labile linkage. − This type of approach can significantly extend drug release and minimize burst effects, with release kinetics governed primarily by the degradation kinetics of the hydrogel. In some instances, it can also introduce stimuli-responsive release of drugs, if, for example, the linkages are cleavable by specific environmental factors such as pH or expression of a specific enzyme . Alternatively, light and heat-cleavable linkages open the door to exogenously triggered drug release. , Overall, these strategies provide significantly more control over the release rate of small molecules, but they do introduce their own complexities.…”

Section: Hydrogels For Drug Deliverymentioning

confidence: 99%

“…While dynamic hydrogels are opening up new translational possibilities, significant progress is also being made to introduce unprecedented levels of functionality into biomaterials. This includes features such as nanoscale patterning of bioactive molecules, , programmable drug release, , and stimuli-responsive behaviors. , As a consequence, much of the research in this space is trending toward increasingly interdisciplinary projects that recruit the expertise of nanotechnologists, chemists, protein engineers, and synthetic biologists to develop sophisticated multifunctional hydrogels. These novel systems include the rise of programmable behavior in hydrogels reminiscent to the behaviors we now associate with digital technology .…”

Section: Introductionmentioning

confidence: 99%

“…These novel systems include the rise of programmable behavior in hydrogels reminiscent to the behaviors we now associate with digital technology . For example, significant advancements have been made to transform simple PEG-based hydrogels into responsive systems based on Boolean-logic gating decisions (e.g., YES, AND, OR operations) by incorporating functional peptides and proteins into the hydrogel network. ,, Programmable biotechnologies are already leading to smart injectable materials with the potential to degrade or release drugs based on either endogenous or exogenous triggers. , As these capabilities continue to mature, multifunctional and programmable hydrogels may provide the technological foundation for platforms that can engage more effectively with the complex, multistage biological events that govern processes such as tissue regeneration and immunity.…”

Section: Introductionmentioning

confidence: 99%

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Translational Applications of Hydrogels

et al. 2021

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Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant to a range of biomedical purposesthey can deliver drugs or cells, regenerate hard and soft tissues, adhere to wet tissues, prevent bleeding, provide contrast during imaging, protect tissues or organs during radiotherapy, and improve the biocompatibility of medical implants. These capabilities make hydrogels useful for many distinct and pressing diseases and medical conditions and even for less conventional areas such as environmental engineering. In this review, we cover the major capabilities of hydrogels, with a focus on the novel benefits of injectable hydrogels, and how they relate to translational applications in medicine and the environment. We pay close attention to how the development of contemporary hydrogels requires extensive interdisciplinary collaboration to accomplish highly specific and complex biological tasks that range from cancer immunotherapy to tissue engineering to vaccination. We complement our discussion of preclinical and clinical development of hydrogels with mechanical design considerations needed for scaling injectable hydrogel technologies for clinical application. We anticipate that readers will gain a more complete picture of the expansive possibilities for hydrogels to make practical and impactful differences across numerous fields and biomedical applications.

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Section: Considerations For Small Molecule Deliverymentioning

confidence: 99%

Section: Hydrogels For Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Translational Applications of Hydrogels

et al. 2021

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“…Small molecules (model therapeutics) labile linked with nondegradable host hydrogel can be released in the preprogrammed way according to Boolean logic. Depending on the type of linkage, YES, OR, and AND logic elements can be realized by different types of inputs (enzymes, chemical reductants, light) and their combinations [147,148].…”

Section: Logicmentioning

confidence: 99%

Chemical Systems for Life Science

Nikolaev¹,

Ryzhkov²,

Gershenson³

et al. 2021

Rev Adv Mater Tech

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The use of dynamic, adaptive materials with feedback control is a tendency of the past decade. Life sciences and medicine require materials with the controlled and responsive assembly of various components on the scales from molecular to macroscopic and even robotics. The main idea of this review is the use of synthetic systems as regulatory networks that facilitate the integration of chemical and biological materials. The synthetic systems, which are inspired by biochemical regulatory networks, help synthetic material to adapt to environmentand to interact with living matter cooperatively. The first step in realizing this concept is designing simple model systems. The simplicity means that the system should contain a minimal number of components but should be robust and sustainable to perform the required functions through logic operations and feedback loops. Here we suggest specific examples of robust systems for the selected functionality: compartmentalized signaling cascades, computation with light-induced chemical gradients andadvanced biomimetic mixed organic-inorganic materials, and self-regulation in chemical-biological systems. The main challenges for the given examples are discussed, and future prospects of logic operation with chemical systems are provided.

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Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

Zhu

Yang

et al. 2020

Adv Funct Materials

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Photoresponsive hydrogels (PRHs) are soft materials whose mechanical and chemical properties can be tuned spatially and temporally with relative ease. Both photo‐crosslinkable and photodegradable hydrogels find utility in a range of biomedical applications that require tissue‐like properties or programmable responses. Progress in engineering with PRHs is facilitated by the development of theoretical tools that enable optimization of their photochemistry, polymer matrices, nanofillers, and architecture. This review brings together models and design principles that enable key applications of PRHs in tissue engineering, drug delivery, and soft robotics, and highlights ongoing challenges in both modeling and application.

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Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

Abstract: Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic.

Cited by 37 publications

References 33 publications

Translational Applications of Hydrogels

Translational Applications of Hydrogels

Chemical Systems for Life Science

Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

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