Long chain lipid based tamoxifen NLC. Part I: Preformulation studies, formulation development and physicochemical characterization

Shete, Harshad; Patravale, Vandana

doi:10.1016/j.ijpharm.2013.03.034

Cited by 136 publications

(66 citation statements)

References 47 publications

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“…1 shows the DSC thermograms of pure TC, F1, sorbitol, poloxamer 407 and GMO. It is clear that the DSC thermogram of TC exhibits a single sharp characteristic, endothermic melting peak at 145.84 C which is in agreement with the data reported previously [29], while that of sorbitol, poloxamer 407 and GMO show endothermic peaks at 104.50 C, 57.95 C and 36 C, respectively. The DSC thermogram of F1 showed absence of TC melting peak and presence of the characteristic peak of sorbitol with no change in its melting point.…”

Section: Powder Flowabilitysupporting

confidence: 91%

Sorbitol based powder precursor of cubosomes as an oral delivery system for improved bioavailability of poorly water soluble drugs

Nasr

Dawoud

2016

Journal of Drug Delivery Science and Technology

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Section: Powder Flowabilitysupporting

confidence: 91%

Sorbitol based powder precursor of cubosomes as an oral delivery system for improved bioavailability of poorly water soluble drugs

Nasr

Dawoud

2016

Journal of Drug Delivery Science and Technology

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“…Selected types of lipids affect the characteristics of NLCs formulation. e solubility of CP in lipids was determined by the test tube method [20]. e CP (1 mg) was weighed in the test tube.…”

Section: Development Of Nlcsmentioning

confidence: 99%

“…Entrapment efficiency and extract loading were evaluated by the ultrafiltration method with some modifications [20]. In brief, CP-loaded NLCs were divided into 2 parts for analyzing entrapment efficacy: formulation for determining total CP and formulation for determining unloaded CP.…”

Section: Entrapment Efficiency and Extract Loading Of Cp-loadedmentioning

confidence: 99%

Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

Nitthikan

Leelapornpisid

Natakankitkul

et al. 2018

Journal of Nanotechnology

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e aim of this study was to develop green robusta coffee beans extract loaded nanostructured lipid carriers (NLCs) for enhancing dermal application and its efficiency. e green robusta coffee beans extract cultivated in Chumphon (CP) exhibited the highest antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with IC 50 of 34.1 ± 0.9 µg/ml, lipid peroxidation inhibition with percentage inhibition of 38.8 ± 1.7, and ferric reducing antioxidant power (FRAP) assay with a FRAP value of 234.5 ± 12.3 mM FeSO 4 /g. e extract contained caffeine, chlorogenic acid, and caffeic acid as major compounds. e anti-inflammatory test indicated that CP could decrease the secretion of IL-6 in macrophage cells and caused no irritation to blood vessels on the irritation test by hen's egg test chorioallantoic membrane (HET-CAM) assay. e particle size of CP-loaded NLCs was 158.1 ± 0.2 nm with a narrow polydispersity index and showed no noticeable difference after the stability test. Entrapment efficacy of CP-loaded NLCs was found to be over 60%. Caffeine and chlorogenic acid in CP-loaded NLCs were released sustainably and penetrated deeper into the skin than the extract in a conventional emulsion. In conclusion, the CP-loaded NLCs can be further used in cosmetics for dermal applications due to good efficacy and safety.

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“…In vitro release of EGCG from SDEDDS was performed in phosphate buffer saline (PBS, Thermo Scientific) by dialysis method [35]. The SDEDDS dispersion (2 mL, corresponding to 6 mg of EGCG) was suspended in dialysis bag (MWCS 12,000 Da, Biosharp, USA).…”

Section: In Vitro Releasementioning

confidence: 99%

Development and characterization of a self-double-emulsifying drug delivery system containing both epigallocatechin-3-gallate and α-lipoic acid

Zhao

Xia

et al. 2015

J Mater Sci

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The present study investigated a self-doubleemulsifying drug delivery system (SDEDDS) loaded with epigallocatechin-3-gallate (EGCG) and a-lipoic acid to improve EGCG photostability and possess a sustained release behavior. The long chain solid lipids (cetostearyl alcohol) and macadamia oil were utilized as a carrier to codeliver the two bioactive ingredients. The prepared EA-SDEDDS for topical application was formulated using modified two-step method and characterized by confocal microscopy, in vitro release, and antioxidant effects. EA-SDEDDS was found to be stable under simulated sunlight for 1 month (at room temperature). In vitro cell culture studies, EA-SDEDDS provided protection for 3t3 fibroblasts that underwent H 2 O 2 oxidative stress due to sustained release property. Cellular antioxidant activity assay indicated that EA-SDEDDS showed anti-oxidative capacity with the same efficacy compared to EGCG-a-lipoic acid solution.

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Long chain lipid based tamoxifen NLC. Part I: Preformulation studies, formulation development and physicochemical characterization

Cited by 136 publications

References 47 publications

Sorbitol based powder precursor of cubosomes as an oral delivery system for improved bioavailability of poorly water soluble drugs

Sorbitol based powder precursor of cubosomes as an oral delivery system for improved bioavailability of poorly water soluble drugs

Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers

Development and characterization of a self-double-emulsifying drug delivery system containing both epigallocatechin-3-gallate and α-lipoic acid

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