Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study

Irwinda, Rima; Hiksas, Rabbania; Siregar, Aprilia Asthasari; Saroyo, Yudianto Budi; Wibowo, Noroyono

doi:10.1038/s41598-021-93846-w

Cited by 16 publications

(16 citation statements)

References 49 publications

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“…PUFAs are mainly localized in cytoplasmic membranes and are degraded for energy generation through the citric acid cycle and ketogenesis. Despite the known beneficial effects of omega-6 and omega-3, in patients with HDP, long-chain polyunsaturated fatty acids are thought to increase the risk of preeclampsia and preterm birth ( Irwinda et al, 2021 ). Furthermore, 2-hydroxyvalerate was also noted to be increased in patients with HDP.…”

Section: Discussionmentioning

confidence: 99%

Exosome-Enriched Plasma Analysis as a Tool for the Early Detection of Hypertensive Gestations

et al. 2021

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Hypertensive disorders of pregnancy are closely associated with prematurity, stillbirth, and maternal morbidity and mortality. The onset of hypertensive disorders of pregnancy (HDP) is generally noticed after the 20th week of gestation, limiting earlier intervention. The placenta is directly responsible for modulating local and systemic physiology by communicating using mechanisms such as the release of extracellular vesicles, especially exosomes. In this study, we postulated that an analysis of exosome-enriched maternal plasma could provide a more focused and applicable approach for diagnosing HDP earlier in pregnancy. Therefore, the peripheral blood plasma of 24 pregnant women (11 controls, 13 HDP) was collected between 20th and 24th gestational weeks and centrifuged for exosome enrichment. Exosome-enriched plasma samples were analyzed by Raman spectroscopy and by proton nuclear magnetic resonance metabolomics (1H NMR). Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze the Raman data, from the spectral region of 600–1,800 cm–1, to determine its potential to discriminate between groups. Using principal component analysis, we were able to differentiate the two groups, with 89% of all variances found in the first three principal components. In patients with HDP, most significant differences in Raman bands intensity were found for sphingomyelin, acetyl CoA, methionine, DNA, RNA, phenylalanine, tryptophan, carotenoids, tyrosine, arginine, leucine, amide I and III, and phospholipids. The 1H NMR analysis showed reduced levels of D-glucose, L-proline, L-tyrosine, glycine, and anserine in HDP, while levels of 2-hydroxyvalerate, polyunsaturated fatty acids, and very-low-density lipoprotein (VLDL) were increased. 1H NMR results were able to assign an unknown sample to either the control or HDP groups at a precision of 88.3% using orthogonal partial least squares discriminant analysis and 87% using logistic regression analysis. Our results suggested that an analysis of exosome-enriched plasma could provide an initial assessment of placental function at the maternal-fetal interface and aid HDP diagnosis, prognosis, and treatment, as well as to detect novel, early biomarkers for HDP.

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Section: Discussionmentioning

confidence: 99%

Exosome-Enriched Plasma Analysis as a Tool for the Early Detection of Hypertensive Gestations

et al. 2021

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“…A single-cell transcriptomics of the human placenta analysis indicated LPCAT3 and Sat1 (spermidine/ spermine N1-acetyltransferase 1) highly expressed in trophoblasts (Ng et al, 2019), both of which are related to ferroptosis (Dixon et al, 2015;Ou et al, 2016). Irwinda, R., et al reported that the level of PUFAs significantly increased in PE patients (Irwinda et al, 2021;Liao et al, 2022). Furthermore, in rats model of PE, the concentration of MDA, the end product of lipid peroxidation, in the placenta has increased dramatically (Zhang et al, 2020).…”

Section: Pre-eclampsiamentioning

confidence: 99%

Role of ferroptosis in pregnancy related diseases and its therapeutic potential

Zhang²,

Wang³

et al. 2023

Front. Cell Dev. Biol.

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Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that ferroptosis is associated with pregnancy related diseases, such as spontaneous abortion, pre-eclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and spontaneous preterm birth. According to these findings, inhibiting ferroptosis might be a potential option to treat pregnancy related diseases. This review summarizes the mechanisms and advances of ferroptosis, the pathogenic role of ferroptosis in pregnancy related diseases and the potential medicines for its treatment.

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“…This result suggests that low plasma DHA and EPA concentrations during pregnancy may be a strong risk factor for preterm birth. A cross-sectional study in 2021 also suggested that the plasma DHA levels of PT pregnant women at delivery were significantly lower than those of full-term pregnant women [ 17 ]. However, this study did not compare the plasma DHA levels of PT pregnant women at delivery with the plasma DHA levels of full-term pregnant women at the corresponding gestational weeks, and there is no study to dynamically monitor the changes in plasma DHA levels of pregnant women throughout the whole pregnancy, so it is not possible to confirm whether the results are caused by different gestational weeks.…”

Section: Preterm Birth (Pt)mentioning

confidence: 99%

“…Therefore, maternal DHA intake and placental transport function are critical for fetal DHA acquisition [ 15 ]. However, in some pregnancy complications, low maternal DHA levels [ 16 , 17 ] or dysfunction in placental fatty acid transport [ 18 , 19 ] leads to DHA deficiency in the offspring, which may lead to long-term neurological disorders. Thus, women with pregnancy complications may benefit from DHA supplementation.…”

Section: Introductionmentioning

confidence: 99%

DHA supplementation and pregnancy complications

et al. 2023

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Docosahexaenoic acid (DHA) supplementation is recommended for women during pregnancy because of its neurological, visual, and cognitive effects. Previous studies have suggested that DHA supplementation during pregnancy may prevent and treat certain pregnancy complications. However, there are contradictions in the current related studies, and the specific mechanism by which DHA acts remains unclear. This review summarizes the research on the relationship between DHA intake during pregnancy and preeclampsia, gestational diabetes mellitus, preterm birth, intrauterine growth restriction, and postpartum depression. Furthermore, we explore the impact of DHA intake during pregnancy on the prediction, prevention, and treatment of pregnancy complications as well as its impact on offspring neurodevelopment. Our results suggest that there is limited and controversial evidence for the protective effect of DHA intake on pregnancy complications, with the exception of preterm birth and gestational diabetes mellitus. However, additional DHA supplementation may improve long-term neurodevelopmental outcomes in the offspring of women with pregnancy complications.

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Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study

Cited by 16 publications

References 49 publications

Exosome-Enriched Plasma Analysis as a Tool for the Early Detection of Hypertensive Gestations

Exosome-Enriched Plasma Analysis as a Tool for the Early Detection of Hypertensive Gestations

Role of ferroptosis in pregnancy related diseases and its therapeutic potential

DHA supplementation and pregnancy complications

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