Long COVID Symptomatology After 12 Months and Its Impact on Quality of Life According to Initial Coronavirus Disease 2019 Disease Severity

Fischer, Aurélie; Zhang, Lu; Elbéji, Abir; Wilmes, Paul; Oustric, Pauline; Staub, Thérèse; Nazarov, Petr V.; Ollert, Markus; Fagherazzi, Guy

doi:10.1093/ofid/ofac397

Cited by 38 publications

(61 citation statements)

References 44 publications

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“…Importantly, at the time of writing only one report by Wang et al [45], indicated the possibility of increased rotavirus A-mediated enteric infections in COVID-19 patients. These findings are intriguing given the propensity for COVID-19 patients to suffer from enteric symptoms [3], including nausea [46] and diarrhoea [47]. Whether the rotavirus, especially in adults, is associated with COVID-19 gastrointestinal symptoms, or the enteric effects exacerbate the expression of rotavirus C-associated genes is still unknown and will have to be investigated in dedicated follow-up studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although COVID-19 is primarily considered a respiratory disease, it clinically often presents with general (fever, myalgia and/or fatigue) and respiratory symptoms (cough and/or dyspnea). Moreover, an emergence of new variants has led to the more frequent presentation of gastrointestinal symptoms (appetite loss, nausea, vomiting and diarrhoea) [3], indicating a potential involvement of the gastrointestinal tract in COVID-19. More specifically, SARS-CoV-2 has been shown to be able to infect and replicate in enterocytes in vitro [4].…”

Section: Introductionmentioning

confidence: 99%

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Altered infective competence of the human gut microbiome in COVID-19

Nies

Galata

Martin-Gallausiaux

et al. 2022

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Objectives: Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection and healthy individuals have been reported, including the loss of commensal taxa. We aimed to understand if microbiome alterations including functional shifts are unique to severe cases or a common effect of COVID-19. Design: We used high-resolution systematic multi-omic analyses to profile the gut microbiome in asymptomatic-to-moderate COVID-19 individuals compared to a control group. Results: We found a striking increase in the overall abundance and expression of both virulence factors and antimicrobial resistance genes in COVID-19. Importantly, these genes are encoded and expressed by commensal taxa from families such as Acidaminococcaceae and Erysipelatoclostridiaceae, which we found to be enriched in COVID-19 positive individuals. We also found an enrichment in the expression of a betaherpesvirus and rotavirus C genes in COVID-19 positive individuals compared to healthy controls. Conclusion: Our analyses identified an altered and increased infective competence of the gut microbiome in COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered infective competence of the human gut microbiome in COVID-19

Nies

Galata

Martin-Gallausiaux

et al. 2022

Preprint

Self Cite

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“…Persisting symptoms were collected using a list of 62 symptoms [11], further divided into 8 categories: ear/nose/throat symptoms, neurological and ocular symptoms, general symptoms, cardio-respiratory symptoms or diseases, gastrointestinal symptoms, vascular and ganglionic symptoms or diseases, urinary symptoms, and skin symptoms (see Online Supplementary Table 1 for the full list).…”

Section: Study Populationmentioning

confidence: 99%

“…A one-size-fits-all care strategy for people with Long COVID is therefore not possible and a better understanding of sub-forms of Long COVID would allow to develop personalized care for people with Long COVID or be integrated as a screening tool for future clinical trials [11]. To date, few studies used clustering analysis to identify and characterize different Long COVID phenotypes [8,12,13].…”

Section: Introductionmentioning

confidence: 99%

Long COVID Classification: Findings from a Clustering Analysis in the Predi-COVID Cohort Study

Fischer¹,

Badier²,

Zhang³

et al. 2022

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The increasing number of people living with Long COVID requires the development of more personalized care, as for now limited treatment options and rehabilitation programs adapted to the variety of Long COVID presentations are available. Our objective was to design an easy-to-use Long COVID classification to help stratifying people with Long COVID. Individual characteristics and a detailed set of 62 self-reported persisting symptoms together with quality of life indexes 12 months after initial COVID-19 infection were collected in a cohort of SARS-CoV-2 infected people in Luxembourg. A hierarchical ascendant classification (HAC) was used to identify clusters of people. We identified 3 patterns of Long COVID symptoms with a gradient in disease severity. Cluster-Mild encompassed almost 50% of the study population and was composed of participants with less severe initial infection, fewer comorbidities, and fewer persisting symptoms (mean=2.9). Cluster-Moderate was characterized by a mean of 11 persisting symptoms and a poor sleep and respiratory quality of life. Cluster-Severe was characterized by a higher proportion of women and smokers as in the other clusters, with a higher number of Long COVID symptoms, in particular of vascular, urinary, and skin symptoms. Our study evidenced that Long COVID can be stratified in 3 sub-categories in terms of severity. If replicated in other populations, this simple classification will help clinicians to personalize the care of people with Long COVID.

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“…Statistics shows that among these symptoms, the symptoms of nervous system and cardiovascular system are the most, and seriously affect the quality of life of patients. [ 4 ] At present, there is no specific drug to treat “long COVID-19.” [ 4 , 5 ] The treatment of “long COVID-19” in modern medicine mainly use of drugs to improve related symptoms, combined with multi-disciplinary rehabilitation model and telerehabilitation. Research shows that traditional Chinese medicine combined with moxibustion has a good effect on improving the symptoms of patients with chronic coronavirus disease.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine combined with Moxibustion in the treatment of “long-COVID”: A protocol for systematic review and meta-analysis

et al. 2022

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Background: From the end of 2019 to now, COVID-19 is still prevalent, which poses a great threat to international public health. With the increasing number of people infected, the number of patients with COVID-19 sequelae is also increasing, but there is no specific drug for COVID-19 sequelae. In China, traditional Chinese medicine combined with acupuncture has been widely used in COVID-19 sequelae, but there is still a lack of evidence-based medicine evaluation. The purpose of this study was to evaluate the efficacy and safety of traditional Chinese medicine combined with moxibustion in the treatment of COVID-19 sequelae.Methods: According to the retrieval strategy, the "long COVID" randomized controlled trial of traditional Chinese medicine combined with moxibustion will be search in eight databases composed of PubMed, Embase, Web of Science, China National knowledge Infrastructure Database, China Biomedical Database and China Science and Technology Journal Database, regardless of publication date or language. The study was screened according to the inclusion and exclusion criteria, and the Cochrane risk bias assessment tool was used to evaluate the quality of the study. Meta-analysis was carried out using RevMan5.3 and STATA12.0 software. Finally, the level of evidence of the results will be evaluated.Results: This study will evaluate whether traditional Chinese medicine combined with moxibustion can effectively treat the symptoms of COVID-19 sequelae.Conclusion: This study will provide evidence whether there is benefit of traditional Chinese medicine combined with moxibustion in the treatment of COVID-19 sequelae. At the same time, our research results will provide a reference for clinical decision-making and guiding development in the future.

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Long COVID Symptomatology After 12 Months and Its Impact on Quality of Life According to Initial Coronavirus Disease 2019 Disease Severity

Cited by 38 publications

References 44 publications

Altered infective competence of the human gut microbiome in COVID-19

Altered infective competence of the human gut microbiome in COVID-19

Long COVID Classification: Findings from a Clustering Analysis in the Predi-COVID Cohort Study

Traditional Chinese medicine combined with Moxibustion in the treatment of “long-COVID”: A protocol for systematic review and meta-analysis

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