Long intragenic non‐coding <scp>RNA</scp> linc<scp>RNA</scp>‐p21 suppresses development of human prostate cancer

Wang, Xiaohai; Ruan, Yuan; Wang, Xingjie; Zhao, Wei; Jiang, Qi; Jiang, Chuanwen; Zhao, Yang; Xu, Yongzhi; Sun, Feng; Zhu, Yiping; Xia, Shujie; Xu, Danfeng

doi:10.1111/cpr.12318

Cited by 39 publications

(35 citation statements)

References 26 publications

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“…As a result, a total of 18 articles met the inclusion criteria and were included in the final analysis (Figure 1 ). Quantitative real-time polymerase chain reaction (qRT-PCR) [ 18 – 26 ]or in situ hybridization assay (ISH) [ 27 ]was performed to measure the LncRNAs expression. The rest of the studies took advantage of information from several databases which include sequencing data from the cohorts of patients PCa [ 17 , 20 , 28 – 32 ].…”

Section: Resultsmentioning

confidence: 99%

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

Chen

Ding

et al. 2017

Oncotarget

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The abnormally expressed LncRNAs played irreplaceable roles in the prognosis of prostate cancer (PCa). Therefore, we conducted this systematic review and meta-analysis to summarize the association between the expression of LncRNAs, prognosis and clinicopathology of PCa. 18 eligible studies were recruited into our analysis, including 18 on prognosis and 9 on clinicopathological features. Results indicated that aberrant expression of LncRNAs was significantly associated with biochemical recurrence-free survival (BCR-FS) (HR = 1.55, 95%CI: 1.01–2.37, P < 0.05), recurrence free survival (RSF) (HR = 3.07, 95%CI: 1.07–8.86, P < 0.05) and progression free survival (PFS) (HR = 2.34, 95%CI: 1.94–2.83, P < 0.001) in PCa patients. LncRNAs expression level was correlated with several vital clinical features, like tumor size (HR = 0.52, 95%CI: 0.28–0.95, P = 0.03), distance metastasis (HR = 4.55, 95%CI: 2.26–9.15, P < 0.0001) and histological grade (HR = 6.23, 95% CI: 3.29–11.82, P < 0.00001). Besides, down-regulation of PCAT14 was associated with the prognosis of PCa [over survival (HR = 0.77, 95%CI: 0.63–0.95, P = 0.01), BCR-FS (HR = 0.61, 95%CI: 0.48–0.79, P = 0.0001), prostate cancer-specific survival (HR = 0.64, 95%CI: 0.48–0.85, P = 0.002) and metastasis-free survival (HR = 0.61, 95%CI: 0.50-0.74, P < 0.00001)]. And, the increased SChLAP1 expression could imply the worse BCR-FS (HR = 2.54, 95%CI: 1.82-3.56, P < 0.00001) and correlate with Gleason score (< 7 vs ≥ 7) (OR = 4.11, 95% CI: 1.94-8.70, P = 0.0002). Conclusively, our present work demonstrated that LncRNAs transcription level might be potential prognostic markers in PCa.

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Section: Resultsmentioning

confidence: 99%

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

Chen

Ding

et al. 2017

Oncotarget

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“…22,34,35 Previous studies showed that lincRNA-p21 was downregulated in several tumors including hepatocellular carcinoma, nonsmall cell lung cancer, and prostate cancer. 30,36,37 For example, Jia et al 38 demonstrated that the expression of lincRNA-p21 was downregulated in 37 demonstrated that lincRNA-p21 expression was decreased in prostate cancer and the lower expression level of lincRNA-p21 was associated with the prediction of poor survival and high disease stage. They indicated that overexpression of lincRNA-p21 suppressed the prostate cancer cell colony formation and proliferation.…”

Section: Discussionmentioning

confidence: 99%

LincRNA‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway

Chen

Yuan

Yang

et al. 2018

J of Cellular Biochemistry

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Long noncoding RNAs (lncRNAs) are a large and diverse class of transcribed RNA molecules with a length of more than 200 nucleotides that modulate the gene expression at the posttranscriptional or transcriptional level. LncRNAs played crucial roles in many biological processes, such as cell proliferation, metastasis, and migraton. In this study, we evaluated the role of lincRNA‐p21 in the gastric cancer (GC). We demonstrated that the expression level of lincRNA‐p21 was downregulated in the GC tissues and cell lines. Moreover, ectopic expression of lincRNA‐p21 suppressed the GC cell growth, cell cycle, and migration. Furthermore, we demonstrated that the X‐ray increased the expression level of lincRNA‐p21 in both the HCG‐27 and SGC7901 cells and elevated expression of lincRNA‐p21 increased the radiotherapy sensitivity of the GC cell. In addition, we showed that ectopic expression of lincRNA‐p21 suppressed the β‐catenin and c‐myc expression. Overexpression of lincRNA‐p21 inhibited the GC cell proliferation and increased the radiosensitivity of GC cells by regulating the β‐catenin signaling pathway. These data suggested that lincRNA‐p21 acted as a tumor suppressor gene in the development of GC.

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“…Likewise, we detected the expression of PKM2 in the prostate cancer specimens and separate normal tissues which were used in our previous study. 11 The results showed that PKM2 was significantly up-regulated in those prostate cancer tissues ( Figure 1H). Taken together, these data indicate that lincRNA-p21 expression is inversely correlated with PKM2 expression in prostate cancer patients.…”

Section: Pkm2 Expression Is Inversely Correlated With Lincrna-p21 Lmentioning

confidence: 90%

LincRNA‐p21 suppresses development of human prostate cancer through inhibition of PKM2

Wang

et al. 2017

Cell Proliferation

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Long intragenic non‐coding RNA lincRNA‐p21 suppresses development of human prostate cancer

Abstract: Our findings indicated that lincRNA-p21 inhibited development of human prostate cancer partly by regulating p53 downstream gene expression and partly by apoptotic activation.

Cited by 39 publications

References 26 publications

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

The prognostic value of long noncoding RNAs in prostate cancer: a systematic review and meta-analysis

LincRNA‐p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β‐catenin signaling pathway

LincRNA‐p21 suppresses development of human prostate cancer through inhibition of PKM2

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