Long‐lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3‐year pharmacological management

Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia?

“…In our case, the haemorrhage was controlled for a 3-year period. Hormonal therapy is debated, but Coppola et al [5] suggested that the combination of octreotide and oestroprogesterone therapy could be helpful in the management of intestinal bleedings in GT's patients.…”

Radiofrequency ablation using Barrx^® for the endoscopic treatment of gastric antral vascular ectasia: a series of three cases and a review of the literature on treatment options

“…Three of the 17 patients were cirrhotics with GAVE. Resolution of bleeding was seen in one patient, and the other two patients had a decrease in transfusion requirements over a 2-year period 28. The success seen in these patients with underlying cirrhosis may be due to the fact that octreotide causes a decrease in portal pressure.…”

“…A further nine of the 18 patients had a moderate reduction in transfusion requirements. The effect was equivocal in one patient,28 and treatment completely failed in another 24. Nardone et al reported a case series of 17 patients with vascular irregularities of the gastrointestinal tract refractory to endoscopic treatment.…”

GASTRIC ANGIODYSPLASIA IN A CHILD WITH BERNARD-SOULIER SYNDROME: Efficacy of Octreotide in Long-Term Management

“…Although it occurs mostly as an occasional abnormality, it might be associated with a number of systemic diseases, including cirrhosis, chronic renal failure, scleroderma, aortic stenosis, and bleeding disorders such as congenital or acquired von Willebrand disease (vWd), inherited disorders of platelet function, thrombocytopenia, and factor X deficiency, as well [6][7][8][9][10][11][12]. Angiodysplasia has been reported in association with BSS in adult patients [3,4], but, to the best of our knowledge, this is the first pediatric case of angiodysplasia associated with BSS.…”

“…The lesions of angiodysplasia may occur in any part of the intestine, most notably in cecum or ascending colon and may cause significant blood loss [5]. There are several options for the management of bleeding gastrointestinal angiodysplasia, such as surgical resection, endoscopic therapy, and administration of estroprogesterons or octreotide [4,5,11]. Although varying degrees of success have been reported, none of those therapeutic apporoaches has been cited as a preferred treatment modality [3][4][5]14].…”