Long‐Lasting Reactive Oxygen Species Generation by Porous Redox Mediator‐Potentiated Nanoreactor for Effective Tumor Therapy

Abstract

The therapeutic efficiency of reactive oxygen species (ROS)‐based nanotherapeutics is restrained by the rigorous production conditions of relatively sufficient and kinetically matching supply of intracellular substrates. The cumulative disruption of redox homeostasis and consequent pathology (e.g., Parkinson's disease) with low levels of substrates in living organisms may provide a promising model for ROS‐based therapy. Herein, a catechol chemistry‐mediated ternary nanostructure is prepared for long‐lasting generation of oxidative •OH in weakly acidic, low H2O2 homeostasis conditions of tumor. This platform employs mesoporous polydopamine (MPDA) as the porous redox mediator, while PDA‐induced sequential precipitation and biomineralization lead to hydroxy iron oxide (FeOOH) as the “iron reservoir,” and calcium phosphate (CaP) as the pH‐sensitive sheddable shell. In weakly acidic conditions, the CaP layer can be degraded to expose the catalytic surface of Fe‐dopamine interplay, where FeOOH dissolution, Fe(III) chelation, Fe(III) reduction, Fe(II) release take place sequentially and continuously for Fe(II) recycling and Fenton catalysis. Both in vitro and in vivo studies verify the significant inhibition of cancer cells and tumor regression, which can also be strengthened by the local photothermal heating. This work establishes the first paradigm of pathologically inspired nanohybrids of ROS generators with long‐lasting efficacy for cancer therapy.

Gold-Platinum Nanoparticles with Core-Shell Configuration as Efficient Oxidase-like Nanosensors for Glutathione Detection

“…These data were calculated assuming a molar extinction coefficient (ε) for TMB ox of 3.9·10 4 L·mol −1 ·cm −1 [ 46 ]. Analogous results were obtained fitting the experimental data retrieved from OPD oxidation ( Figure 2 e) (R 2 = 0.99) and its Lineweaver-Burk plot ( Figure 2 f) (R 2 = 0.99).…”

Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer

“…In addition, the PDA catechol functional group exhibits excellent chelation with metal ions (Fe, Mn, Zn, etc. ), binding stably binding with manganese (Zhao et al., 2016 ; Zhang et al., 2020 ; Ding et al., 2021 ). In addition, MRI can guide synergetic CDT/PTT which corresponds to the trend of treatment and diagnosis integration.…”

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

“…The combination of catechol chemistry and -conjugated backbones with electrochemical properties relevant to organic electronics can bring PDA and PDA-like derivatives a number of exciting properties and potential biomedical applications. For example, the redox-active properties have been explored in the construction of batteries to power medical devices, [187,188] redox mediators to boost ROS generation catalysis, [189] as well as electrochemical transistors for sensing of biochemical markers. [190,191] Rendering the materials with large surface areas and highly exposed catechol/quinone sites by the aforementioned strategies may potentially improve interface process-relevant/dominant properties in these applications.…”