Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in rats

Diehl, Luisa Amalia; Silveira, Patrícia Pelufo; Leite, Marina Concli; Crema, Leonardo Machado; Portella, André Krumel; Billodre, Mauro Nör; Nunes, Edelvan; Henriques, Thiago Pereira; Fidelix-da-Silva, Linda Brenda; Heis, Marta Dalpian; Gonçalves, Carlos Alberto; Quillfeldt, Jorge Alberto; Dalmaz, Carla

doi:10.1016/j.brainres.2007.01.084

Cited by 75 publications

(34 citation statements)

References 57 publications

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“…The lack of differences in basal CORT plasma levels between male and female SR animals is in accordance with studies showing that, at the time of the circadian rhythm and the stage of estrous cycle here considered, males and females do not show differences in CORT plasma levels (Critchlow, Liebelt, Bar-Sela, Mountcastle, & Lipscomp, 1963;Diehl et al, 2007). However, in the present study, adult males showed a rise in plasma CORT to the acute stressor, independently of their rearing condition, while OR females showed a blunted CORT release compared to SR ones.…”

Section: Discussionsupporting

confidence: 91%

Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

Uriarte

Ferreira

Rosa

et al. 2008

Developmental Psychobiology

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In rats, mating at postpartum estrus and delayed dispersal of the young would result in the overlapping of two different-age litters. As a consequence, newborn pups' early experience will include not only that acquired during the interaction with the mother and age-matched littermates, but also with older siblings. As early-life experience modulates rodents' brain function, behavior and reproduction, we aimed to assess how changes in the early environment provoked by the overlapping of litters would affect emotionality, stress response and reproductive functions of male and female pups during adulthood. Results showed that both male and female overlapped reared pups exhibited a reduced behavioral inhibition in the open field test during adulthood. In addition, overlapped reared adult females, but not males, showed a blunted corticosterone response to an acute stressor during diestrus and a reduction in sexual behavior. In summary, natural changes in early experience provoked by the overlapping of litters, long-term modulate affective and reproductive behaviors, and the endocrine stress response in a sex dimorphic manner.

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Section: Discussionsupporting

confidence: 91%

Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

Uriarte

Ferreira

Rosa

et al. 2008

Developmental Psychobiology

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“…Finally, the current data are in stark contrast to a large body of data on rats subjected to a common model of early-life stress, maternal separation (MS), in which rats that are separated daily from their mothers for several hours (≥3) during the first two weeks of life exhibit HPA hyper-reactivity to stressors and increased depressive-like symptoms as adults (Diehl et al, 2007;Lippmann et al, 2007). We were originally interested in a comparison to this model because of the considerable crosstalk between stressors and immune system activation.…”

Section: Discussionmentioning

confidence: 76%

Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats

Bilbo

Yirmiya

Amat

et al. 2008

Psychoneuroendocrinology

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Both early-life stress and immune system activation in adulthood have been linked independently to depression in a number of studies. However, the relationship between early-life infection, which may be considered a "stressor", and later-life depression has not been explored. We have reported that neonatal bacterial infection in rats leads to exaggerated brain cytokine production, as well as memory impairments, to a subsequent peripheral immune challenge in adulthood, and therefore predicted that stressor-induced depressive-like symptoms would be more severe in these rats as well. Rats treated on postnatal day 4 with PBS or E. coli were as adults exposed to inescapable tailshock stress (IS), and then tested for sucrose preference, social exploration with a juvenile, and overall activity, 1, 3, 5, and 7 days following the stressor. Serum corticosterone and extracellular 5-HT within the basolateral amygdala were measured in a second group of rats in response to the IS. IS resulted in profound depressive-like behaviors in adult rats, but, surprisingly, rats that suffered a bacterial infection early in life had blunted corticosterone responses to the stressor and were remarkably protected from the depressive symptoms compared to controls. These data suggest that early-life infection should be considered within a cost/benefit perspective, in which outcomes in adulthood may be differentially protected or impaired. These data also suggest that the immune system likely plays a previously unsuspected role in "homeostatic" HPA programming and brain development, which may ultimately lend insight into the often-contradictory literature on cytokines, inflammation, and depression.

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“…We observed a CSF/serum ratio for S100B ranging from 3 to 5 in rats; however, shed blood collected during cardiothoracic surgery in humans (by LIA-Sangtec) or after decapitation in rats presented extremely elevated serum S100B values (using ELISA for S100B [60]; using LIA-Sangtec for S100B, LV Portela, unpublished results).…”

Section: Introductionmentioning

confidence: 68%

Biological and methodological features of the measurement of S100B, a putative marker of brain injury

Gonçalves

Leite

Nardin

2008

Clinical Biochemistry

229

169

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Long lasting sex-specific effects upon behavior and S100b levels after maternal separation and exposure to a model of post-traumatic stress disorder in rats

Cited by 75 publications

References 57 publications

Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats

Biological and methodological features of the measurement of S100B, a putative marker of brain injury

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