Long non‑coding RNA BRM promotes proliferation and invasion of papillary thyroid carcinoma by regulating the microRNA‑331‑3p/SLC25A1 axis

Liu, Shihong; Zhang, Deping; Chen, Li; Gao, Shangfang; Huang, Xiu

doi:10.3892/ol.2020.11418

Cited by 7 publications

(7 citation statements)

References 36 publications

(33 reference statements)

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“…The fundamental role of CIC and its upregulation in cancer, inflammation, and beyond is well described in a recent review article by Mosaoa et al [ 187 ]. CIC was found to be overexpressed in different types of cancer: breast cancer [ 188 ], colorectal cancer [ 189 ], prostate cancer [ 190 ], hepatomas [ 191 ], thyroid carcinoma [ 192 ], and others. These multiple studies clearly demonstrate that CIC is essential for the proliferation of different types of cancer cells.…”

Section: Definition Of the “ β -Oxidation Shuttle”mentioning

confidence: 99%

A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

Zhelev

Aoki

Lazarova

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cancer metabolism is an extensively studied field since the discovery of the Warburg effect about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has become clear that glycolysis is not the only abnormally activated metabolic pathway in the cancer cells, but the same is true for the fatty acid synthesis (FAS) and mevalonate pathway. In the last decade, a lot of data have been accumulated on the pronounced mitochondrial fatty acid oxidation (mFAO) in many types of cancer cells. In this article, we discuss how mFAO can escape normal regulation under certain conditions and be overactivated. Such abnormal activation of mitochondrial β-oxidation can also be combined with mutations in certain enzymes of the Krebs cycle that are common in cancer. If overactivated β-oxidation is combined with other common cancer conditions, such as dysfunctions in the electron transport complexes, and/or hypoxia, this may alter the redox state of the mitochondrial matrix. We propose the idea that the altered mitochondrial redox state and/or inhibited Krebs cycle at certain segments may link mitochondrial β-oxidation to the citrate-malate shuttle instead to the Krebs cycle. We call this abnormal metabolic condition “β-oxidation shuttle”. It is unconventional mFAO, a separate metabolic pathway, unexplored so far as a source of energy, as well as a source of cataplerosis, leading to biomass accumulation, accelerated oxygen consumption, and ultimately a source of proliferation. It is inefficient as an energy source and must consume significantly more oxygen per mole of ATP produced when combined with acetyl-CoA consuming pathways, such as the FAS and mevalonate pathway.

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Section: Definition Of the “ β -Oxidation Shuttle”mentioning

confidence: 99%

A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

Zhelev

Aoki

Lazarova

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…From the same families of genes discovered to be the target of several microRNAs we mention CXCL-12/16 [16,86], CCNG-1/2 [17,100], IRS-1/2 [19,107], FGF-2/FR [28,112], CCDC-6/67 [52,128], FOX-O1/E1/M1 [27,55,76], ITGA-3/6 [55,61], SL-1A5/25A1 [56,118], MAP-2K4/K1/4K3 [71,78,120], and SOX 11/12/2 [84,95,117].…”

Section: One Gene Can Be Targeted By Several Micrornasmentioning

confidence: 99%

MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020

Hîțu

Gabora

Bonci

et al. 2020

Cancers

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The involvement of micro-ribonucleic acid (microRNAs) in metabolic pathways such as regulation, signal transduction, cell maintenance, and differentiation make them possible biomarkers and therapeutic targets. The purpose of this review is to summarize the information published in the last two and a half years about the involvement of microRNAs in papillary thyroid carcinoma (PTC). Another goal is to understand the perspective offered by the new findings. Main microRNA features such as origin, regulation, targeted genes, and metabolic pathways will be presented in this paper. We interrogated the PubMed database using several keywords: “microRNA” + “thyroid” + “papillary” + “carcinoma”. After applying search filters and inclusion criteria, a selection of 137 articles published between January 2018–June 2020 was made. Data regarding microRNA, metabolic pathways, gene/protein, and study utility were selected and included in the table and later discussed regarding the matter at hand. We found that most microRNAs regularly expressed in the normal thyroid gland are downregulated in PTC, indicating an important tumor-suppressor action by those microRNAs. Moreover, we showed that one gene can be targeted by several microRNAs and have nominally described these interactions. We have revealed which microRNAs can target several genes at once.

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“…Recent studies have shown that in patients affected by papillary thyroid carcinoma (PTC), the long non-coding non-coding RNA for association with Brahma, (lncBRM), is significantly upregulated, correlating with poor overall survival [ 47 ]. lncBRM targets CIC activity via the microRNA miR-331-3p and promotes PTC cell proliferation, migration and invasion, an effect that is rescued by inhibiting CIC.…”

Section: Cic Inhibition Inhibits the Growth Of Different Tumor Typmentioning

confidence: 99%

The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

et al. 2021

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The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. Citrate is central to mitochondrial metabolism and respiration and plays fundamental activities in the cytosol, serving as a metabolic substrate, an allosteric enzymatic regulator and, as the source of Acetyl-Coenzyme A, also as an epigenetic modifier. In this review, we highlight the complexity of the mechanisms of action of this transporter, describing its involvement in human diseases and the therapeutic opportunities for targeting its activity in several pathological conditions.

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Long non‑coding RNA BRM promotes proliferation and invasion of papillary thyroid carcinoma by regulating the microRNA‑331‑3p/SLC25A1 axis

Cited by 7 publications

References 36 publications

A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

MicroRNA in Papillary Thyroid Carcinoma: A Systematic Review from 2018 to June 2020

The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

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