Long non-coding RNA GHET1 Is Possibly Involved in the Pathogenesis of a Fraction of Breast Cancers

Abstract

Background: Breast cancer is the most frequently diagnosed cancer among women. Although several targeted therapies have been applied for patients with breast cancer, due to its heterogeneous nature, several patients do not benefit from these treatment modalities. Consequently, it is necessary to identify novel markers, which participate in the development of breast cancer. Recently, long non-coding RNAs (lncRNAs) have gained attention in this regard. Among them is lncRNA-gastric carcinoma high expressed transcript 1 (lncRNA-GHET1), whose participation in gastric and bladder cancers have been identified. Objectives: In the present study, we aimed at identifying lncRNA-GHET1 expression in breast cancer tissues compared with their adjacent non-cancerous tissues (ANCT) in a cohort of Iranian patients. Methods: We evaluated the expression of GHET1 in 47 samples of invasive ductal carcinoma of breast in comparison with their ANCTs by means of quantitative real time-PCR. Results: GHET1 has been shown to be up-regulated in 26% (13 out of 47) breast tumor samples compared with their paired ANCTs. Transcript levels of GHET1 were shown to be associated with body mass index. No other significant association was found between the level of transcripts and patients' clinical data, such as estrogen receptor, progesterone receptor, Her2/neu status, tumor stage or grade. Conclusions: GHET1 is possibly contributed in the pathogenesis of a fraction of breast cancers

Retracted: Long noncoding RNA PCAT‐1 knockdown prevents the development of ovarian cancer cells via microRNA‐124‐3p

“…First, PCAT-1 was reported to be specifically overexpressed in prostate cancer. 12 Recently, its overexpression was gradually observed in breast cancer, 13 colorectal cancer, 10 esophageal squamous carcinoma, 14 bladder cancer. 11 Here, for the first time, we reported that PCAT-1 was accumulated in a subset of OC tissues.…”

“…8 Further, the modulatory association of lncRNA and miR offers new perception of the molecular mechanisms during the onset and process of cancer. 9 To date, the overexpression of lncRNA prostate cancer-associated transcript 1 (PCAT-1) and its possible role have been reported in several cancers, [10][11][12][13][14][15] while studies about its role has not been conducted in OC.…”

Molecular Aspect of Propofol's Effect on Cytotoxic and Long Non-Coding RNA (lncRNA) Expressions in MCF-7

“…In addition, PCAT-1 is effective in the EMT and Wnt/β-catenin signaling pathway [23]. Similarly, upregulated PCAT-1 has been found in breast cancer tissue [24].…”

Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers

“…A total of 12 eligible articles containing 761 patients with cancers were included in this meta-analysis after screening titles, abstracts or full texts. 18,21,22,[30][31][32][33][34][35][36][37][38] The process of article selection was shown in Figure 1.…”