Long non-coding RNA TP73‑AS1 promotes colorectal cancer proliferation by acting as a ceRNA for miR‑103 to regulate PTEN expression

Jia, Zeming; Peng, Jian; Yang, Zhi; Chen, Jie; Liu, Ling; Luo, Danni; He, Panxiang

doi:10.1016/j.gene.2018.11.072

Cited by 23 publications

(15 citation statements)

References 28 publications

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“…Interesting, in one study Jia et al showed that TP73-AS1 is downregulated in CRC and inhibited cell proliferation by sponging miR-103 to regulate PTEN. 13 In contrast, in another study, Cai et al reported that TP73-AS1 was overexpressed in CRC and promoted cancer cell proliferation, migration and invasion by upregulating TGFα 14 In this study we found TP73-AS1 was upregulated in CRC tissues but was not affected by clinical stages. Therefore, the TP73-AS1 was not further upregulated with the development of CRC.…”

Section: Discussioncontrasting

confidence: 69%

“…9 Therefore, the regulation of lncRNA expression may have potential therapeutic value for cancer treatment. 10 Although LncRNA TP73-AS1 has been proved to promote several types of cancer including CRC, [11][12][13][14] two recent studies reported opposite expression patterns and functionality of TP73-AS1 in CRC. Our study was therefore performed to further explore the role of TP73-AS1 in CRC.…”

Section: Introductionmentioning

confidence: 99%

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<p>LncRNA TP73-AS1 Activates TGF-β1 to Promote the Migration and Invasion of Colorectal Cancer Cell</p>

Jin²,

2019

CMAR

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Purpose: LncRNA TP73-AS1 has been demonstrated to promote the developments of several types of human cancer. However, its role in colorectal cancer (CRC) is unknown. Methods: All CRC patients (n=70, 40 males and 30 females, 38 to 66 years' old, 52.1 ± 5.3 years' old) in this study were enrolled in the Affiliated Hospital of Southwest Medical University from July 2012 to January 2014. Cells, vectors, and transient transfections, RT-qPCR, western-blotting, as well as measurements of cell migration and invasion abilities were carried out during the research. Results: In the present study, we found that TP73-AS1 was upregulated in CRC tissues compared with adjacent non-CRC tissues in CRC patients. Upregulation of TP73-AS1 was closely correlated with poor prognosis. TGF-β1 was also upregulated in CRC tissues and positive correlated with TP73-AS1. TP73-AS1 overexpression caused upregulated TGF-β1 in CRC cells, while TGF-β1 overexpression showed no significant effect on TP73-AS1. TP73-AS1 and TGF-β1 overexpressions caused enhanced migration and invasion of CRC cells. TGF-β inhibitor treatment caused suppressed migration and invasion of CRC cells and attenuated effects of TP73-AS1 and TGF-β1 overexpression. Conclusion: Therefore, TP73-AS1 may inactivate TGF-β1 to inhibit the migration and invasion of CRC cells.

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Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

<p>LncRNA TP73-AS1 Activates TGF-β1 to Promote the Migration and Invasion of Colorectal Cancer Cell</p>

Jin²,

2019

CMAR

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“…Long non‐coding RNA (lncRNA) is a recently discovered member of the non‐coding RNA family . Recently, there is increasing evidence that non‐coding RNAs (ncRNAs) play a key role in human cancer biology . These ncRNA molecules over 200 nucleotides in length are named long non‐coding RNAs (lncRNAs) that regulate mRNA translation, transcriptional processes and cell development, differentiation, proliferation and apoptosis .…”

Section: Introductionmentioning

confidence: 99%

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

Cao

et al. 2019

J Cellular Molecular Medi

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Long non‐coding RNA (lncRNA) is one of the important regulators of many malignancies. However, the biological function and clinical significance of a large number of lncRNAs in gastric cancer remain unclear. Therefore, we analysed the TCGA data to find that LINC01303 is significantly up‐regulated in gastric cancer tissues. However, the biological function of LINC01303 in GC remains unknown. In our study, we found that the expression of LINC01303 was significantly higher in GC tissues than in adjacent tissues by real‐time quantitative PCR. We can significantly inhibit the malignant proliferation, migration and invasion of GC cells by silencing LINC01303 expression. In addition, LINC01303 knockdown can also inhibit GC growth in vivo. After the bioinformatics analysis, we found that LINC01303 can be used as a miR‐101‐3p sponge to competitively adsorb miR‐101‐3p with EZH2. Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR‐101‐3p activity and promotes GC progression. In summary, in this study, we demonstrated for the first time that the LINC01303/miR‐101‐3p/EZH2 axis promotes GC progression.

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“…Additionally, TP73-AS1 overexpression significantly promoted CRC apoptosis and inhibited cell growth. Functionally, TP73-AS1 facilitated CRC cell proliferation by inducing phosphate and tension homology deleted on chromsome ten (PTEN) expression by binding to miR-103 [22]. All these results have provided a foresight into the potential role of a TP73-AS1 signaling pathway mediating CRC.…”

Section: Colorectal Cancermentioning

confidence: 90%

Role of long non-coding RNA TP73-AS1 in cancer

2019

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Cancer incidence rate has increased so much that it is the second leading cause of deaths worldwide after cardiovascular diseases. Sensitive and specific biomarkers are needed for an early diagnosis of cancer and in-time treatment. Recent studies have found that long non-coding RNAs (lncRNAs) participate in cancer tumorigenesis. LncRNA P73 antisense RNA 1T (TP73-AS1), also known as KIAA0495 and p53-dependent apoptosis modulator (PDAM), is located in human chromosomal band 1p36.32 and plays a crucial role in many different carcinomas. This review summarizes current findings on the role of TP73-AS1 and its signaling pathways in various cancers, including glioma, esophageal squamous cell carcinoma (ESCC), hepatocellular carcinoma (HCC), colorectal cancer (CRC), osteosarcoma, gastric cancer (GC), clear cell renal cell carcinoma (ccRCC), breast cancer (BC), bladder cancer, ovarian cancer, cholangiocarcinoma (CCA), lung cancer, and pancreatic cancer. Its aberrant expression generally correlates with clinicopathological characterization of patients. Moreover, TP73-AS1 regulates proliferation, migration, invasion, apoptosis, and chemoresistance cancer mechanisms, both in vivo and in vitro, through different signaling pathways. Therefore, TP73-AS1 may be considered as a marker for diagnosis and prognosis, also as a target for cancer treatment.

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Long non-coding RNA TP73‑AS1 promotes colorectal cancer proliferation by acting as a ceRNA for miR‑103 to regulate PTEN expression

Cited by 23 publications

References 28 publications

<p>LncRNA TP73-AS1 Activates TGF-β1 to Promote the Migration and Invasion of Colorectal Cancer Cell</p>

<p>LncRNA TP73-AS1 Activates TGF-β1 to Promote the Migration and Invasion of Colorectal Cancer Cell</p>

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

Role of long non-coding RNA TP73-AS1 in cancer

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