Long non-coding RNAs regulate the hallmarks of cancer in HPV-induced malignancies

Dias, Tânia R.; Santos, Julia M.; Costa, Rui M. Gil da; Medeiros, Rui

doi:10.1016/j.critrevonc.2021.103310

Cited by 4 publications

(7 citation statements)

References 156 publications

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“…Studies have revealed that lncRNAs exerts key roles in cancer progression [19], and dysregulated lncRNAs were involved with the incidence of HPV-related diseases [20][21][22]. It was reported up-regulation of lncRNA FEZF1-AS1 facilitates cervical carcinoma via sponging miR-367-3p [23].…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of LncRNAs and miRNAs, Revealing Key Biomarkers of Condyloma Acuminata

Zhong

Song

Wang

et al. 2022

Preprint

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Condyloma acuminata (CA), genital wart, is caused by HPV infections and transmitted by sexual contact. Bioinformatics analyses contributes to the discovery of hub genes and non-protein-coding RNAs of novel therapeutic relevance in CA. We screened out dysregulated miRNAs and LncRNAs in gene expression matrix of our own dataset and datasets from Arrayexpress database, GEO database and. Subsequently, miRNA- gene network and LncRNAs-miRNA interaction pair were constructed. Hub genes were identified from PPI network of target genes. It was predicted RP11-1081L13.4 and MIR31HG commonly interacted with miR-31a-5p, which is up regulated in CA. Functional enrichment analyses of GO and KEGG revealed the potential role of MAPK pathways in CA. RT-qPCR results showed that miR-31-5p was over-expressed in CA tissues. Downregulated miR-31-5p increased apoptosis and reduced proliferation and migration ability of Hela cell lines in vitro via downregulating MAPK pathway. These findings suggested that MIR31HG, RP11-1081L13.4, especially miR-31-5p and hub genes were promising biomarkers, contributing to CA pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Integrative Analysis of LncRNAs and miRNAs, Revealing Key Biomarkers of Condyloma Acuminata

Zhong

Song

Wang

et al. 2022

Preprint

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“…LncRNAs are ncRNAs longer than 200 nucleotides with the particularity of forming secondary structures, which enables them to bind to other biomolecules such as DNA, RNA and even proteins, thus affecting gene expression at different levels [25][26][27][28]. Another feature of these ncRNAs is the fact that they can function in the nucleus, where they are transcribed, but also at the cytoplasm, with most of them operating in both.…”

Section: Lncrnas: a Novel Epigenetic Regulator In Vtementioning

confidence: 99%

“…Similarly to messenger RNAs (mRNAs), lncRNAs are also transcribed by RNA Polymerase II and are often capped and polyadenylated, also presenting evolutionarily conserved patterns and a high level of tissue specificity [28]. According to the NONCODE database (version 6.0) (http://www.noncode.org, accessed on 24 May 2023), there are 96,411 human lncRNA genes [30].…”

Section: Lncrnas: a Novel Epigenetic Regulator In Vtementioning

confidence: 99%

“…On the other hand, guide lncRNAs can recruit RNA-binding proteins to target genes, while scaffolds may bring together several proteins to build complexes with specific biological roles, influencing transcription. Of note, lncRNAs localized in the nucleus can modify chromatin, activate or repress transcription of target genes by interacting with DNA sequences or transcription factors, while cytoplasmic lncRNAs are mostly associated with mRNA stability and translation, promoting or repressing protein synthesis [28,35,36]. Specifically, in the nucleus, lncRNAs are known to interact with DNA methyltransferases or Despite the inconsistency in classification, the roles of lncRNAs in gene expression regulation can be divided into four main non-exclusive archetypes: signalling, decoy, guide and scaffold functions (Figure 3) [26].…”

Section: Lncrnas: a Novel Epigenetic Regulator In Vtementioning

confidence: 99%

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Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?

Marques

Tavares

Neto

et al. 2023

IJMS

Self Cite

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Venous thromboembolism (VTE), a common condition in Western countries, is a cardiovascular disorder that arises due to haemostatic irregularities, which lead to thrombus generation inside veins. Even with successful treatment, the resulting disease spectrum of complications considerably affects the patient’s quality of life, potentially leading to death. Cumulative data indicate that long non-coding RNAs (lncRNAs) may have a role in VTE pathogenesis. However, the clinical usefulness of these RNAs as biomarkers and potential therapeutic targets for VTE management is yet unclear. Thus, this article reviewed the emerging evidence on lncRNAs associated with VTE and with the activity of the coagulation system, which has a central role in disease pathogenesis. Until now, ten lncRNAs have been implicated in VTE pathogenesis, among which MALAT1 is the one with more evidence. Meanwhile, five lncRNAs have been reported to affect the expression of TFPI2, an important anticoagulant protein, but none with a described role in VTE development. More investigation in this field is needed as lncRNAs may help dissect VTE pathways, aiding in disease prediction, prevention and treatment.

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“…Otro de los ejemplos de cáncer, donde se sabe que la disbiosis promueve el desarrollo de otra de sus marcas distintivas, la inflamación, es el carcinoma oral de células escamosas (COCE). La inflamación crónica es una condición que se ha asociado a cáncer durante varios años (Hanahan & Weinberg, 2011), ya que promueve la liberación de factores de crecimiento que inducen la proliferación celular y también la liberación de enzimas de matriz extracelular que facilitan la invasión, la metástasis y la angiogénesis (Dias et al, 2021). En COCE, se ha observado en saliva que un aumento en el conteo de las bacterias Porphyromonas gingivalis, Fusobacterium nucleatum y Prevotella intermedia, mediante la técnica de checkerboard DNA-DNA hybridization (Mager et al, 2005) están asociados a periodontitis que es un tipo de inflamación en las encías (Gholizadeh et al, 2016).…”

Section: Relación Del Microbioma Y El Cáncerunclassified

La Hologenómica y su relación con el cáncer

Arriaga-Canon¹,

Contreras-Espinosa²,

Manríquez³

et al. 2021

RECEIN

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Un holobionte es considerado una entidad biológica asociada en simbiosis con microorganismos que complementan sus vías metabólicas, sus funciones fisiológicas y su variación genética. El término hologenoma se refiere a todo el contenido genético del holobionte, es decir, a la suma del genoma del hospedero, sus organelos junto con los genomas del microbioma que lo componen. En la actualidad se ha establecido que existe una relación entre el desarrollo de enfermedades y el microbioma de los humanos, por lo que en esta revisión se describirá el papel del hologenoma en el cáncer y las técnicas de secuenciación masiva en paralelo aplicadas en la hologenómica. El estudio de la hologenómica junto con las tecnologías en secuenciación y bionformática proporcionará información relevante para el desarrollo de nuevas herramientas diagnósticas y su posterior aplicación en la práctica clínica.

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Long non-coding RNAs regulate the hallmarks of cancer in HPV-induced malignancies

Cited by 4 publications

References 156 publications

Integrative Analysis of LncRNAs and miRNAs, Revealing Key Biomarkers of Condyloma Acuminata

Integrative Analysis of LncRNAs and miRNAs, Revealing Key Biomarkers of Condyloma Acuminata

Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?

La Hologenómica y su relación con el cáncer

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