Long non‐coding <scp>RNA IGF2‐AS</scp> promotes trophoblast cell proliferation, migration, and invasion by regulating <scp>miR</scp>‐520g/N‐cadherin axis

Li, Mei; Zhang, Hong; Kong, Qingbi

doi:10.1111/jog.14886

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…CDH2 has been confirmed to be up-regulated in breast cancer, prostate cancer, and melanoma [41]. However, it has been shown that miRNAs can inhibit CDH2 expression by binding the 3-UTR of CDH2 through sponge action [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

Deng,

Wang,

Zhang

et al. 2023

Aging

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HBV-associated hepatitis B virus x protein (HBx) plays multiple roles in the development of hepatocellular carcinoma. In our prior study, we discovered that miR-187-5p expression was inhibited by HBx. To investigate the underlying molecular mechanism of HBx-mediated miR-187-5p downregulation in hepatocellular carcinoma cells, effects of HBx and miR-187-5p on hepatoma carcinoma cell were observed, as well as their interactions. Through in vitro and in vivo experiments, we demonstrated that overexpression of miR-187-5p inhibited proliferation, migration, and invasion. Simultaneously, we observed a dysregulation in the expression of miR-187-5p in liver cancer cell lines, which may be attributed to transcriptional inhibition through the E2F1/FoxP3 axis. Additionally, we noted that HBx protein is capable of enhancing the expression of E2F1, a transcription factor that promotes the expression of FoxP3. In conclusion, our results suggest that the inhibitory effect of HBx on miR-187-5p is mediated through the E2F1/FoxP3 axis. As shown in this work, HBx promotes hepatoma carcinoma cell proliferation, migration, and invasion through the E2F1/FoxP3/miR-187 axis. It provides a theoretical basis for finding therapeutic targets that will help clinic treatment for HCC.

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Section: Discussionmentioning

confidence: 99%

HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

Deng,

Wang,

Zhang

et al. 2023

Aging

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“…Trophoblast cells are the most important cells in early pregnancy, and their proliferation, migration and invasion are essential for the establishment and maintenance of pregnancy [ 20 ]. It was reported that placental development mainly depends on the differentiation, proliferation, migration, and invasion of trophoblast cells, therefore, a favorable and unique maternal‐fetal microenvironment is beneficial for fetal survival and development [ 25 , 26 ]. More importantly, insufficient trophoblast migration and invasion lead to impaired uterine spiral artery reconstruction and are associated with RSA [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

IL-23 Inhibits Trophoblast Proliferation, Migration, and EMT via Activating p38 MAPK Signaling Pathway to Promote Recurrent Spontaneous Abortion

Ning

et al. 2022

J. Microbiol. Biotechnol.

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Recurrent spontaneous abortion (RSA), defined as the loss of ≥2 consecutive pregnancies before the 24th gestational week, affects 1%-2% women during their reproductive age [1]. As a common condition in reproductive medicine, RSA is reported in 1-2% of fertile couples seeking pregnancy and inflicts a significant physical, emotional, and financial burden on many families [2]. Many factors are thought to contribute to RSA, such as parental chromosomal abnormalities, maternal thrombophilia, immune dysfunction, and various endocrine disorders [3]. In addition, the age of the pregnant mother has also been reported to be a strong independent risk factor for miscarriage, and in particular, the risk of fetal miscarriage greatly increases after 35 years of age [4]. However, in many cases, the causes of RSA could not be easily identified, while the evidence-based diagnostic and treatment strategies are in short supply and the prospects of treatment are not as promising as they could be [5].Interleukin 23 (IL-23), which is composed of a p40 subunit and a specific p19 subunit, belongs to the IL-12 cytokine family and is secreted by dendritic cells and macrophages [6,7]. Accumulated reports have confirmed that IL-23 participates in the development of some autoimmune inflammatory diseases, including psoriasis, arthritis, and inflammatory bowel disease, thus serving as a critical therapeutic target for the improvement of inflammatory diseases [8][9][10]. In addition, another study reported that IL-23 was upregulated in patients with RSA [11]. Moreover, both IL-17 and IL-23 were verified to inhibit Langerhans cell (LC) migration in a psoriasis As a vital problem in reproductive health, recurrent spontaneous abortion (RSA) affects about 1% of women. We performed this study with an aim to explore the molecular mechanism of interleukin-23 (IL-23) and find optimal or effective methods to improve RSA. First, ELISA was applied to evaluate the expressions of IL-23 and its receptor in HTR-8/SVneo cells after IL-23 treatment. CCK-8, TUNEL, wound healing and transwell assays were employed to assess the proliferation, apoptosis, migration and invasion of HTR-8/SVneo cells, respectively. Additionally, the expressions of apoptosis-, migration-, epithelial-mesenchymal transition-(EMT-) and p38 MAPK signaling pathway-related proteins were measured by western blotting. To further investigate the relationship between IL-23 and p38 MAPK signaling pathway, HTR-8/SVneo cells were treated for 1 h with p38 MAPK inhibitor SB239063, followed by a series of cellular experiments on proliferation, apoptosis, migration and invasion, as aforementioned. The results showed that IL-23 and its receptors were greatly elevated in IL-23-treated HTR-8/SVneo cells. Additionally, IL-23 demonstrated suppressive effects on the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells. More importantly, the molecular mechanism of IL-23 was revealed in this study; that is to say, IL-23 inhibited the proliferation, apoptosis, migration, invas...

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“…functions as a competitive endogenous RNA of miR-651-3p to regulate YY1 on progress of spiral artery remodelling [190] uc.187 is up-regulated in preeclampsia and modulates proliferation, apoptosis, and invasion of HTR-8/SVneo cells [191] SPRY4-IT1 modulates trophoblast cell invasion and migration by affecting the epithelialmesenchymal transition [192] up-regulation modulates proliferation, migration, apoptosis, and network formation in HTR-8SV/neo cells [16] NN An lncRNA within intron 3 of the STOX2 gene which seems to regulate an essential trophoblast differentiation pathway [193] XIST has a role in X chromosome inactivation in females, a process that is paternal specific in the trophoblast and random in the fetus [194,195] lncRHOXF1 is the first example of an lncRNA from the X chromosome that regulates the host response to viral infections in human placental progenitor cells [196] LncRNA-TCL6 plays a role in early abortion by inhibiting placental implantation via the EGFR pathway [197] LncRNaIGF2-AS plays a role in recurrent miscarriage by regulating trophoblast functions [198] PVT1 is down-regulated in GDM and PE [199] HOTAIR plays an important role in suppressing angiogenesis of the human placenta by inhibiting the expression of VEGFA [171] NEAT1 is increased in intrauterine growth retardation (IUGR) placentas but the pathomechanism is not yet clear; up-regulation is inducing apoptosis in HTR-8/SVneo cells [200,201]…”

Section: Lncrna Function Citationmentioning

confidence: 99%

The Role of Non-Coding RNAs in the Human Placenta

Hufsky

Markert

Marz

2022

Cells

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Non-coding RNAs (ncRNAs) play a central and regulatory role in almost all cells, organs, and species, which has been broadly recognized since the human ENCODE project and several other genome projects. Nevertheless, a small fraction of ncRNAs have been identified, and in the placenta they have been investigated very marginally. To date, most examples of ncRNAs which have been identified to be specific for fetal tissues, including placenta, are members of the group of microRNAs (miRNAs). Due to their quantity, it can be expected that the fairly larger group of other ncRNAs exerts far stronger effects than miRNAs. The syncytiotrophoblast of fetal origin forms the interface between fetus and mother, and releases permanently extracellular vesicles (EVs) into the maternal circulation which contain fetal proteins and RNA, including ncRNA, for communication with neighboring and distant maternal cells. Disorders of ncRNA in placental tissue, especially in trophoblast cells, and in EVs seem to be involved in pregnancy disorders, potentially as a cause or consequence. This review summarizes the current knowledge on placental ncRNA, their transport in EVs, and their involvement and pregnancy pathologies, as well as their potential for novel diagnostic tools.

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Long non‐coding RNA IGF2‐AS promotes trophoblast cell proliferation, migration, and invasion by regulating miR‐520g/N‐cadherin axis

Cited by 6 publications

References 34 publications

HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

IL-23 Inhibits Trophoblast Proliferation, Migration, and EMT via Activating p38 MAPK Signaling Pathway to Promote Recurrent Spontaneous Abortion

The Role of Non-Coding RNAs in the Human Placenta

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