Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer

Pan, Chunfeng; Yao, Guoliang; Liu, Bin; Ma, Teng; Xia, Yang; Wei, Ke; Wang, Jun; Xu, Jin; Chen, Liang; Chen, Yijiang

doi:10.1159/000480414

Cited by 58 publications

(39 citation statements)

References 44 publications

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“…Wang et al showed that over‐expression of ELF3 promoted cell proliferation and metastasis via PI3K/Akt and ERK signaling pathways in NSCLC . Pan et al demonstrated that lncRNA FAL1 induced cell proliferation, epithelial‐mesenchymal transition, and invasion via modulation of PTEN/AKT signaling pathway in NSCLC . Zhang et al provided evidences that Kctd20 stimulated the development of NSCLC by activating Fak/AKT pathway and related to poor OS of patients .…”

Section: Discussionmentioning

confidence: 99%

Serous IFNA3 predicts unfavorable prognosis in lung cancer via abnormal activation of AKT signaling

Cong

2019

IUBMB Life

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This study addresses the demand through datamining The Cancer Genome Atlas (TCGA) database and elucidates mechanistic involvements of interferon alpha 8 (IFNA8) in lung cancer. The overall survival and disease-free survival of lung cancer patients in respect to IFNA8 expression level were analyzed. IFNA8 expression levels in both serum and tumor tissue were determined by real-time polymerase chain reaction. The diagnostic value of serous IFNA8 in lung cancer was assessed by receiver operating characteristic (ROC) curve analysis. Cell viability and proliferation were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Cell Counting Kit-8 assays. in vivo pro-tumor effect of IFNA8 was evaluated using xenograft tumor model. The metastasis-prone behaviors were determined by Transwell chamber assay and tail vein-injection in mice. Protein levels of p-AKT, total AKT, and endogenous reference actin were analyzed by western blot. We uncovered high IFNA8 associated with unfavorable overall survival and disease-free survival in lung cancer patients from TCGA. We further characterized the aberrant over-expression of IFNA8 in both peripheral blood and solid tumor from our clinical patient panel, and ROC analysis suggested its potential diagnostic value. Ectopic over-expression of IFNA8 promoted viability and proliferation in both A549 and H1299 cells in vitro and accelerated xenograft tumor growth in vivo. Furthermore, IFNA8 facilitated migration, invasion, and metastasis of A549 cells in vivo. Mechanistically, we disclosed the over-activation of AKT signaling in IFNA8-proficient A549 cells, inhibition of which completely abolished the pro-tumor effects of IFNA8. We have identified IFNA8 as a novel biomarker for either diagnostic or prognostic purpose in lung cancer, which is mechanistically associated with abnormal activation of AKT signaling. K E Y W O R D SAKT signaling, biomarker, IFNA8, lung cancer

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Section: Discussionmentioning

confidence: 99%

Serous IFNA3 predicts unfavorable prognosis in lung cancer via abnormal activation of AKT signaling

Cong

2019

IUBMB Life

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“…Focally amplified lncRNA on chromosome 1 (FAL1), a new identified LncRNA located at 1q21.2, had been demonstrated to be up‐regulated and to promote development in several kinds of tumours, especially ovarian cancer . Pan et al reported that FAL1 was obviously overexpressed in NSCLC tissues compared with the adjacent normal tissues and promoted metastasis of NSCLC via the PTEN/AKT axis …”

Section: Main Molecular Mechanism Of Lncrna To Regulate the Metastasimentioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

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Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

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“…In addition XLOC_008466, FAL1, and XIST were examined in NSCLC by Yang [38], Pan [39] and Wang, [40], respectively In their studies, these lncRNA function as an oncogene in NSCLC, which indicates them as a useful marker and potential therapeutic target.…”

Section: Lncrna In Lung Cancer Diagnosis and Tumor Typesmentioning

confidence: 99%

Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer

Peng

Wang

Shan

et al. 2018

Cell Physiol Biochem

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Lung cancer is the leading cause of cancer-related mortality worldwide. Approximately 80% of lung cancer cases are non–small cell lung carcinoma (NSCLC). However current diagnostic and therapeutic modalities against NSCLC are ineffective due to incomplete understanding of molecular pathogenesis of NSCLC. Emerging evidence shows that long non-coding RNAs (lncRNAs) can function as biomarkers for diagnosis and prognosis. LncRNAs can control transcription, translation, and protein function via diverse mechanisms although they lack the protein coding potential. LncRNAs have attracted intense investigations on their roles in cancer. Mounting evidence indicates that lncRNAs are promising biomarkers in diagnosis and prognosis for NSCLC, especially their presence in body fluids. Herein we will review recent advances in the research that explores the diagnostic and prognostic potentials of lncRNAs in NSCLC. We will also discuss emerging evidence that suggested lncRNAs as therapeutic targets in NSCLC.

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Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer

Cited by 58 publications

References 44 publications

Serous IFNA3 predicts unfavorable prognosis in lung cancer via abnormal activation of AKT signaling

Serous IFNA3 predicts unfavorable prognosis in lung cancer via abnormal activation of AKT signaling

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer

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