Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function

Yu, Tina; Chung, Hee Kyoung; Xiao, Lan; Piao, Jinhua; Lan, Shaoyang; Jaladanki, Suraj; Turner, Douglas J.; Raufman, Jean‐Pierre; Gorospe, Myriam; Wang, Jianying

doi:10.1016/j.jcmgh.2019.12.002

Cited by 57 publications

(44 citation statements)

References 58 publications

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“…LncRNA DLEU2 Up Cell proliferation and invasion [12] HULC LncRNA HULC Up Cell proliferation, migration and invasion [68] PCTST LncRNA PCTST Down Inhibits cell proliferation, invasion, tumorigenesis and EMT [73] lncRNAs can be found in exosomes from tumors, providing a very promising research direction for the diagnosis and treatment of PC. Moreover, some lncRNAs increase the growth of intestinal epithelial cells and organoids in mice [89]. This experiment highlights the importance of lncRNAs in organoid and cancer cell survival and the potential of lncRNAs as therapeutic targets in a broad spectrum of cancers.…”

Section: Dleu2mentioning

confidence: 64%

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

Zhou

Chen

et al. 2020

Cancer Cell Int

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Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biological functional diversity and complexity in protein regulatory networks. Scientific studies have revealed the emerging functions and regulatory roles of lncRNAs in PC behaviors. It is worth noting that some in-depth studies have revealed that lncRNAs are significantly associated with the initiation and progression of PC. As lncRNAs have good properties for both diagnostic and prognostic prediction due to their translation potential, we herein address the current understanding of the multifaceted roles of lncRNAs as regulators in the molecular mechanism of PC. We also discuss the possibility of using lncRNAs as survival biomarkers and their contributions to the development of targeted therapies based on the literature. The present review, based on what we know about current research findings, may help us better understand the roles of lncRNAs in PC.

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Section: Dleu2mentioning

confidence: 64%

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

Zhou

Chen

et al. 2020

Cancer Cell Int

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“…LncRNAs and different cell types were involved in the pathophysiology of asthma. Studies showed that increased lncRNA H19 inhibited the function of goblet cells, thus potentially contributing to barrier dysfunction in intestinal pathologies (Yu et al 2020 ). H19 was found differentially expressed in OVA mice in our microarray analysis, thus, H19 could also potentially regulate inflammation of asthma by targeting goblet cells.…”

Section: Discussionmentioning

confidence: 99%

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Zhang

Zhou

et al. 2020

J Bioenerg Biomembr

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Asthma is defined as a heterogeneous disease, usually characterized by chronic airway inflammation. Long noncoding RNAs (lncRNAs) play important roles in various biological processes. To know more about the relationships between lncRNAs and asthma, gene microarray analysis was performed to screen differentially expressed lncRNAs between the lung tissue of ovalbumin (OVA) mice and control mice. Further studies showed that downregulating differentially expressed lncRNA-AK149641 by adeno-associated virus 6 (AAV6) in OVA mice inhibited airway inflammation, with improved airway compliance and resistance, diminished infiltration of inflammatory cells, as well as less secretions of mucus, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Moreover, the activity of nuclear factor-kappa B (NF-κB) in the lung tissue was reduced after downregulating lncRNA-AK149641. In conclusion, we proposed that downregulation of lncRNA-AK149641 attenuated the airway inflammatory response in an OVA-induced asthma mouse model, probably in association with modulation of the NF-κB signaling pathway.

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“…LncRNAs have mainly been studied in cancer, since many of them seem to be deregulated in tumor tissues and linked with cell proliferation, tissue invasion and inflammation [ 7 , 8 ], but also in autoimmune diseases like rheumatoid arthritis or multiple sclerosis [ 9 , 10 ]. In the gut, H19 could regulate intestinal permeability in inflammatory bowel diseases (IBDs) [ 11 , 12 ], whereas lnc13 and HGC14 have been linked with CD [ 13 , 14 ], but their proper function in the disease has not been fully characterized to date.…”

Section: Introductionmentioning

confidence: 99%

Gliadin, through the Activation of Innate Immunity, Triggers lncRNA NEAT1 Expression in Celiac Disease Duodenal Mucosa

Gnodi

Mancuso

Elli

et al. 2021

IJMS

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Celiac disease (CD) is an autoimmune enteropathy arising in genetically predisposed subjects exposed to gluten, which activates both innate and adaptive immunity. Although the pathogenesis is common to all patients, the clinical spectrum is quite variable, and differences could be explained by gene expression variations. Among the factors able to affect gene expression, there are lncRNAs. We evaluated the expression profile of 87 lncRNAs in CD vs. healthy control (HC) intestinal biopsies by RT-qPCR array. Nuclear enriched abundant transcript 1 (NEAT1) and taurine upregulated gene 1 (TUG1) were detected as downregulated in CD patients at diagnosis, but their expression increased in biopsies of patients on a gluten-free diet (GFD) exposed to gluten. The increase in NEAT1 expression after gluten exposure was mediated by IL-15 and STAT3 activation and binding to the NEAT1 promoter, as demonstrated by gel shift assay. NEAT1 is localized in the nucleus and can regulate gene expression by sequestering transcription factors, and it has been implicated in immune regulation and control of cell proliferation. The demonstration of its regulation by gluten thus also supports the role of lncRNAs in CD and prompts further research on these RNAs as gene expression regulators.

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Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function

Cited by 57 publications

References 58 publications

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

Gliadin, through the Activation of Innate Immunity, Triggers lncRNA NEAT1 Expression in Celiac Disease Duodenal Mucosa

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