Long Noncoding RNA LINC00261 Suppresses Cell Proliferation and Invasion and Promotes Cell Apoptosis in Human Choriocarcinoma

Abstract

Choriocarcinoma is one of the gestational trophoblastic neoplasias (GTNs) that originate in the chorionic villi and the extravillous trophoblast. Long noncoding RNAs (lncRNAs) are a type of non-protein-coding RNAs that have recently been implicated in human tumorigenesis. The present study investigated the role of the lncRNA LINC00261 in cell proliferation, metastasis, and apoptosis in choriocarcinoma cell lines. The transcription level of LINC00261 was significantly lower in choriocarcinoma tissues and in choriocarcinoma cell lines. Overexpression of LINC00261 caused a decrease in cell proliferation and arrested the cell cycle at the G0/G1 phase. Furthermore, overexpression of LINC00261 inhibited cell migration and invasion. Meanwhile, it promoted cell apoptosis and the relative activities of caspase 3 and caspase 9 in choriocarcinoma JEG-3 and JAR cells. These data suggested that LINC00261 promotes cell proliferation and metastasis in choriocarcinoma. Our data might provide novel insight into the early diagnosis and treatment of choriocarcinoma in clinics.

Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

“…Although our data showed similar LINC00261 functions on cancer cell aggressiveness as reported previously, 15,[17][18][19]23 the molecular mechanisms are totally different. In colon cancer, LINC00261 downregulates Wnt signalling activity through restraining β-catenin from cytoplasm into nuclei and promoting β-catenin degradation.…”

“…Now, we first time reported that LINC00261 was also downregulated in endometrial carcinoma, and the LINC00261 levels were further decreased in endometrial carcinoma with lymphatic metastasis. Although our data showed similar LINC00261 functions on cancer cell aggressiveness as reported previously, the molecular mechanisms are totally different. In colon cancer, LINC00261 downregulates Wnt signalling activity through restraining β‐catenin from cytoplasm into nuclei and promoting β‐catenin degradation .…”

“…Another lncRNA, LINC00261, is downregulated in gastric cancer, and functions to decrease cell migration and invasion by promoting Slug degradation . Downregulation and similar functions of LINC00261 were also reported in choriocarcinoma and nonsmall cell lung cancer . In hepatocellular carcinoma, LINC00261 impedes cell proliferation and invasion by blocking Notch signalling pathway .…”

Systematic analyses of a novel lncRNA‐associated signature as the prognostic biomarker for Hepatocellular Carcinoma

“…Among these above four lncRNAs in the risk score, decreased LINC00261 was identified associated with poor prognosis and metastasis in Gastric Cancer (GC) . Moreover, LINC00261 was found related to cell growth, migration, cell proliferation, and cell apoptosis in endometriosis and choriocarcinoma . Furthermore, multivariate analyses revealed that expression of CDKN2B‐AS1 could be an independent predictor for OS ( P = .036) in GC .…”

“…37 Moreover, LINC00261 was found related to cell growth, migration, cell proliferation, and cell apoptosis in endometriosis and choriocarcinoma. 38,39 Furthermore, multivariate analyses revealed that expression of CDKN2B-AS1 could be an independent predictor for OS (P = .036) in GC. 40 The other two lncRNAs (TRELM3P and GBP1P1) were not reported till now.…”