Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

Puvvula, Pavan Kumar; Desetty, Rohini Devi; Pineau, Pascal; Marchio, Agnès; Moon, Anne M.; Dejean, Anne; Bischof, Oliver

doi:10.1038/ncomms6323

Cited by 175 publications

(168 citation statements)

References 59 publications

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“…One of them is PANDAR (p21 associated ncRNA DNA damage activated, also known as PANDA), a mono-exonic human lncRNA encoded few kilobases upstream the p21 gene promoter and involved in cell cycle progression, apoptosis and cellular senescence. PANDAR expression is induced upon DNA damage [54] and oncogene-induced senescence (OIS) [55], as result of the p53 binding to a single p53RE located between p21 and PANDAR divergent promoters [54,56].…”

Section: Lncrnas Regulated By P53mentioning

confidence: 99%

Expanding the p53 regulatory network: LncRNAs take up the challenge

Grossi

Sánchez

Huarte

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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Section: Lncrnas Regulated By P53mentioning

confidence: 99%

Expanding the p53 regulatory network: LncRNAs take up the challenge

Grossi

Sánchez

Huarte

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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“…PANDA lncRNA, by interacting with polycomb repressive complexes and the transcription factor NF-YA, endows cells with the capacity to maintain their proliferative state, and alterations in their levels can lead to entry or exit from the senescent state [64].…”

Section: Cis-acting Long Non-coding Rnasmentioning

confidence: 99%

lncRNAs and microRNAs with a role in cancer development

Liz

Esteller

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

476

349

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Most diseases, including human cancer, are frequently associated with an altered transcription pattern. The alteration of the transcriptome is not restricted to the production of aberrant levels of protein-coding RNAs, but also refers to the dysregulation of the expression of the multiple noncoding members that comprise the human genome. Unexpectedly, recent RNA-seq data of the human transcriptome have revealed that less than 2% of the genome encodes protein-coding transcripts, even though the vast majority of the genome is actively transcribed into non-coding RNAs (ncRNAs) under different conditions. In this review, we present an updated version of the mechanistic aspects of some long non-coding RNAs (lncRNAs) that play critical roles in human cancer. Most importantly, we focus on the interplay between lncRNAs and microRNAs, and the importance of such interactions during the tumorigenic process, providing new insight into the regulatory mechanisms underlying several ncRNA classes of importance in cancer, particularly transcribed ultraconserved regions (T-UCRs).

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“…In proliferation cells, the scaffold-attachment protein factor SAFA and the PANDA lncRNA recruit polycomb complexes to repress senescence-promoting genes (Puvvula et al 2014).…”

Section: Regulation Of Senescence By Lncrnasmentioning

confidence: 99%

Noncoding Transcriptional Landscape in Human Aging

Costa

Leitão

Enguita

2015

Current Topics in Microbiology and Immunology

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Aging is a universal phenomenon in metazoans, characterized by a general decline of the organism physiology associated with an increased risk of mortality and morbidity. Aging of an organism correlates with a decline in function of its cells, as shown for muscle, immune, and neuronal cells. As the DNA content of most cells within an organism remains largely identical throughout the life span, age-associated transcriptional changes must be achieved by epigenetic mechanisms. However, how aging may impact on the epigenetic state of cells is only beginning to be understood. In light of a growing number of studies demonstrating that noncoding RNAs can provide molecular signals that regulate expression of protein-coding genes and define epigenetic states of cells, we hypothesize that noncoding RNAs could play a direct role in inducing age-associated profiles of gene expression. In this context, the role of long noncoding RNAs (lncRNAs) as regulators of gene expression might be important for the overall transcriptional landscape observed in aged human cells. The possible functions of lncRNAs and other noncoding RNAs, and their roles in the regulation of aging-related cellular pathways will be analyzed.

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Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

Cited by 175 publications

References 59 publications

Expanding the p53 regulatory network: LncRNAs take up the challenge

Expanding the p53 regulatory network: LncRNAs take up the challenge

lncRNAs and microRNAs with a role in cancer development

Noncoding Transcriptional Landscape in Human Aging

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