Long QT syndrome and anaesthesia

Booker, Peter D.; Whyte, Simon; Ladusans, E J

doi:10.1093/bja/aeg061

Cited by 150 publications

(217 citation statements)

References 119 publications

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“…For this reason, we avoided the use of preanaesthetic drugs in this study. In addition, we used vecuronium for neuromuscular relaxation and tracheal intubation as it has been found to have no effect on the QTc interval [2,8,18]. However, it has been reported that there is no dose-dependency in the dose-response relationship between propofol and the QTc interval [20], and in consideration of tracheal intubation, the effect-site concentration was set at 5 lg.ml )1 in this study.…”

Section: ó 2008 the Authorsmentioning

confidence: 99%

“…Slowly activating (iKs) and rapidly activating (iKr) delayed rectifier channels conduct most of the repolarisation current [21]. It is widely known that inhaled anaesthetic agents block iKr channels, and therefore increase the QTc interval in healthy patients [1,2,7,9,10]. There are no reports that have clearly investigated intravenous anaesthetics, including propofol's contribution to QTc prolongation, but according to Heath et al [22], propofol has been reported to block the delayed rectifier potassium current.…”

Section: ó 2008 the Authorsmentioning

confidence: 99%

“…It has been reported that a prolonged QT interval could lead to sudden death or life-threatening arrhythmia under anaesthesia [2,3]. QT interval can be prolonged not only by congenital mutations of sodium or potassium channels, but also by neurological disorders, electrolyte disturbances, heart disease, and various drugs [1,2,[4][5][6].…”

mentioning

confidence: 99%

“…It is known that most inhalation anaesthetics or intravenous anaesthetics can influence the corrected QT (QTc) interval, and there have been many studies that investigated the different results of this effect [1,2,[7][8][9][10][11][12][13][14]. Some studies report that propofol causes QTc prolongation [14].…”

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Effects of target concentration infusion of propofol and tracheal intubation on QTc interval*

et al. 2008

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Section: ó 2008 the Authorsmentioning

confidence: 99%

Section: ó 2008 the Authorsmentioning

confidence: 99%

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confidence: 99%

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Effects of target concentration infusion of propofol and tracheal intubation on QTc interval*

et al. 2008

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“…Prolongation of QT interval linked to medication may speed up life-threatening arrhythmias like torsades de point and cause a variety of cardiovascular complications [1][2][3] .…”

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confidence: 99%

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

et al. 2014

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PURPOSE:To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QT c interval. METHODS:This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n:5) and neostigmine group (Group N, n:5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/ kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2,5,10,20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex. RESULTS:Comparing the QT c interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QT c interval in the neostigmine group rabbits was significantly increased (p<0.05). CONCLUSION:While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QT c interval, neostigmine+atropine proloned the QT c interval.

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