Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

Abstract

PURPOSE:To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QT c interval. METHODS:This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n:5) and neostigmine group (Group N, n:5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/ kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2,5,10,20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex. RESULTS:Comparing the QT c interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QT c interval in the neostigmine group rabbits was significantly increased (p<0.05). CONCLUSION:While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QT c interval, neostigmine+atropine proloned the QT c interval.

Comparison of Decurarization Using Sugammadex and Neostigmine After Rocuronium During Desflurane Anesthesia

“…Erbaş et al compared the eff ects of sugammadex and neostigmine for QT prolongation in rabbits under general anesthesia. Although sugammadex didn't have any infl uence, neostigmine increased the QT time 23 . Koyuncu et al reported that extubation, fi rst eye opening and head lift times were shorter in patients given sugammadex.…”