2017
DOI: 10.1161/jaha.116.004560
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Long‐Term Administration of Eicosapentaenoic Acid Improves Post–Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization

Abstract: BackgroundConsumption of n‐3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n‐3 fatty acid known to reduce the frequency of nonfatal coronary events; however, the frequency of mortality after myocardial infarction (MI) is not reduced. The aims of this study were to determine whether long‐term administration of EPA regulated cardiac remodeling after MI and to elucidate the underlying therapeutic mechanisms of EP… Show more

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Cited by 35 publications
(17 citation statements)
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References 61 publications
(109 reference statements)
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“…Importantly, MSCs may alter macrophages metabolic status vi a a PGE 2 -dependent mechanism by promoting anti-inflammatory M2 rather than inflammatory M1 polarization ( 48 ); this, in turn, contributes to enhanced IL-10 secretion in the lungs ( 7 , 11 , 13 , 48 ). In mouse models of Duchenne muscular dystrophy and myocardial infarction, EPA was described as an inhibitor of muscle damage through inhibition of M1 and promotion of M2 macrophage polarization when administered systemically ( 49 , 50 ). Thus, EPA-stimulation of MSCs may provide a more targeted delivery of EPA and/or EPA-derived mediators to modulate macrophage polarization.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, MSCs may alter macrophages metabolic status vi a a PGE 2 -dependent mechanism by promoting anti-inflammatory M2 rather than inflammatory M1 polarization ( 48 ); this, in turn, contributes to enhanced IL-10 secretion in the lungs ( 7 , 11 , 13 , 48 ). In mouse models of Duchenne muscular dystrophy and myocardial infarction, EPA was described as an inhibitor of muscle damage through inhibition of M1 and promotion of M2 macrophage polarization when administered systemically ( 49 , 50 ). Thus, EPA-stimulation of MSCs may provide a more targeted delivery of EPA and/or EPA-derived mediators to modulate macrophage polarization.…”
Section: Discussionmentioning
confidence: 99%
“…30 Takamura et al reported that regulating the activation of proinflammatory macrophages post-myocardial infarction improves cardiac remodeling. 31 Indeed, Ly-6C low macrophage has been shown to play a crucial role in the pathogenesis and progression of the healing myocardium. 30 In addition, macrophage-induced fibrosis and several cytokines could aggravate arrhythmogenic properties.…”
Section: Discussionmentioning
confidence: 99%
“…Total RNA was prepared from the hearts of mice using the RNeasy Fibrous Tissue Mini Kit (QIAGEN, Chatsworth, CA, USA) and from the livers using the QuickGene RNA Tissue Kit SII (FUJIFILM, Kanagawa, Japan) [ 33 ]. RT-PCR was carried out using TaqMan Gene Expression Assays and the Universal PCR Master Mix (Applied Biosystems, Foster City, CA, USA), which uses an ABI prism 7900HT Sequence Detection System (Applied Biosystems).…”
Section: Methodsmentioning
confidence: 99%