Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain

Daşdağ, Süleyman; Akdağ, Mehmet; Erdal, Nurten; Ay, Özlem İzci; Ay, Mustafa; Yılmaz, Şenay; Taşdelen, Bahar; Yeğin, Korkut

doi:10.3109/09553002.2015.997896

Cited by 35 publications

(26 citation statements)

References 19 publications

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“…35 In addition, the long-term and excessive use of 900 MHz radiofrequency radiation can alter miRNA expression in the brain. 36 These findings support our results that a 50 Hz ELF-EMF can alter the expression of miR-26b-5p, which may account for the biological effects of ELF-EMF.…”

Section: Discussionsupporting

confidence: 90%

Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

Liu

et al. 2016

Cell Cycle

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The increasing prevalence of extremely low frequency electromagnetic fields (ELF-EMFs) exposure has raised considerable public concern regarding the potential hazardous effects of ELF-EMFs on male reproductive function. Increasing evidence indicates that miRNAs are necessary for spermatogenesis and male fertility. However, the regulation of miRNA expression and the roles of miRNAs in response to ELFEMFs remain unclear. In our study, mouse spermatocyte-derived GC-2 cells were intermittently exposed to a 50 Hz ELF-EMF for 72 h (5 min on/10 min off) at magnetic field intensities of 1 mT, 2 mT and 3 mT. MiR26b-5p was differentially expressed in response to different magnetic field intensities of ELF-EMFs. The host gene CTDSP1 showed an unmethylation status in GC-2 cells at different magnetic field intensities of ELF-EMF exposure. MiR-26b-5p had no significant, obvious influence on the cell viability, apoptosis or cell cycle of GC-2 cells. However, the overexpression of miR-26b-5p significantly decreased the percentage of G0/G1 phase cells and slightly increased the percentage of S phase cells compared to the sham group that was exposed to a 50 Hz ELF-EMF. Computational algorithms identified Cyclin D2 (CCND2) as a direct target of miR-26b-5p. MiR-26b-5p and a 50 Hz ELF-EMF altered the expression of CCND2 at both the mRNA and protein levels. Overexpressed miR-26b-5p in GC-2 cells can change the mRNA expression of CCND2 following 50 Hz ELF-EMF at 3 mT. These findings demonstrate that miR-26b-5p could serve as a potential biomarker following 50 Hz ELF-EMF exposure, and miR-26b-5p-CCND2-mediated cell cycle regulation might play a pivotal role in the biological effects of ELF-EMFs.

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Section: Discussionsupporting

confidence: 90%

Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

Liu

et al. 2016

Cell Cycle

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“…EMF/RFR exposures can also result in epigenetic changes in DNA expression that can impair normal functioning, without causing direct damage to DNA but simply affecting how well DNA functions are carried out (mitochondrial metabolism, production of proteins and immune cells, etc.). New epigenetic studies on mobile phone emissions support this evidence (Dasdag et al., , ).…”

Section: Exposure and Impacts Of Emf And Rfr On Adultsmentioning

confidence: 81%

“…Evidence for an epigenetic cause of damage, that is, modulation of microRNA, is presented by Dasdag et al. (, ) in new studies on 900 MHz cell phone radiation and 2450 MHz Wi‐Fi levels of exposure. Dasdag et al.…”

Section: Epigenetics As a Plausible Biological Mechanism For Emf/rfr mentioning

confidence: 99%

“…Significant impact on stress hormones especially in children and chronically ill adults Avendano et al (2012) 0. Atasoy et al (2013) 0.091 W/kg a Damaged DNA and reduced DNA repair at levels that comply with 802.11 g Wi-Fi public safety limits Dasdag et al (2015a) 0.0369 W/kg a Lowered microRNA activity in brain (3 hr per day exposure for 12 months) 2.023 W/kg b Akdag et al (2016) 141.4 lW/kg a DNA damage in testes by comet assay (24/7 exposure for 12 months-900 MHz cell phone radiation) 7127 lW/kg b Dasdag et al (2015b) 141.4 lW/kg a Lowered microRNA activity in brain (24/7 exposure for 12 months-2.45 GHz Wi-Fi radiation) 7127 lW/kg b a Whole body. b Max SAR.…”

Section: Exposure and Impacts Of Emf And Rfr On Adultsmentioning

confidence: 99%

“…Evidence for an epigenetic cause of damage, that is, modulation of microRNA, is presented by Dasdag et al (2015aDasdag et al ( , 2015b in new studies on 900 MHz cell phone radiation and 2450 MHz Wi-Fi levels of exposure. Dasdag et al (2015b) report that very low-intensity Wi-Fi exposures over a year-long period (24 hr per day) at 141.4 lW/kg (whole body specific absorption rate [SAR]) and a maximum SAR of 7127 lW/kg lowered activity of micro-RNAs in the brain of adult rats.…”

Section: Micrornamentioning

confidence: 99%

See 2 more Smart Citations

Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development

Sage

Burgio

2017

Child Development

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Mobile phones and other wireless devices that produce electromagnetic fields (EMF) and pulsed radiofrequency radiation (RFR) are widely documented to cause potentially harmful health impacts that can be detrimental to young people. New epigenetic studies are profiled in this review to account for some neurodevelopmental and neurobehavioral changes due to exposure to wireless technologies. Symptoms of retarded memory, learning, cognition, attention, and behavioral problems have been reported in numerous studies and are similarly manifested in autism and attention deficit hyperactivity disorders, as a result of EMF and RFR exposures where both epigenetic drivers and genetic (DNA) damage are likely contributors. Technology benefits can be realized by adopting wired devices for education to avoid health risk and promote academic achievement.

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Effects of Low‐Intensity Microwave Radiation on Oxidant‐Antioxidant Parameters and DNA Damage in the Liver of Rats

Alkış

Akdağ

Daşdağ

2020

Bioelectromagnetics

Self Cite

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The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage in tissues. The aim of this study is to examine the possible effects of exposure to low-intensity MWR on DNA and oxidative damage in the livers of rats. Eighteen Sprague-Dawley male rats were divided into three equal groups randomly (n = 6). Group 1 (Sham-control): rats were kept under conditions the same as those of other groups, except for MWR exposure. Group 2: rats exposed to 1800 MHz (SAR: 0.62 W/kg) at 0.127 ± 0.04 mW/cm 2 power density, and Group 3: rats exposed to 2,100 MHz (SAR: 0.2 W/kg) at 0.038 ± 0.03 mW/cm 2 power density. Microwave application groups were exposed to MWR 2 h/day for 7 months. At the end of the exposure period, the rats were sacrificed and DNA damage, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and total oxidant-antioxidant parameter analyses were conducted in their liver tissue samples. It was found that 1800 and 2100 MHz low-intensity MWR caused a significant increase in MDA, 8-OHdG, total oxidant status, oxidative stress index, and comet assay tail intensity (P < 0.05), while total antioxidant status levels (P < 0.05) decreased. The results of our study showed that whole-body exposure to 1800 and 2100 MHz low-intensity MWR emitted by cell phones can induce oxidative stress by altering oxidant-antioxidant parameters and lead to DNA strand breaks and oxidative DNA damage in the liver of rats. Bioelectromagnetics. 2021;42:76-85.

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Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain

Abstract: 900 MHz RF radiation can alter some of the miRNA, which, in turn, may lead to adverse effects. Therefore, further studies should be performed.

Cited by 35 publications

References 19 publications

Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fields

Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development

Effects of Low‐Intensity Microwave Radiation on Oxidant‐Antioxidant Parameters and DNA Damage in the Liver of Rats

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