Long-term and short-term alcohol consumption and levels of C-reactive protein

Raum, Elke; Gebhardt, Katja; Buchner, Matthias; Schiltenwolf, Marcus; Brenner, Hermann

doi:10.1016/j.ijcard.2006.08.104

Cited by 21 publications

(16 citation statements)

References 14 publications

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“…For example, circulating levels of CRP are typically lower in moderate drinkers as compared to non-drinkers and heavy drinkers as observed in the Health Professionals Follow-up Study and Nurse’s Health Study II (NHSII) cohorts, (Pai et al, 2006) and MONICA study (Imhof et al, 2004), with a replication of these data across European (Raum et al, 2007) and Asian populations (Wang et al, 2008). Similar findings are found for circulating levels of IL-6 (Pai et al, 2006; Volpato et al, 2004), although the relationship may be linear, rather than U-shaped, (Mendall et al, 1997) and that the effects are more robust in men (Welsh et al, 2008).…”

Section: Resultsmentioning

confidence: 97%

“…In general, moderate drinking as defined by 1–7 alcohol drinks per week (Albert et al, 2003; Volpato et al, 2004), or 15–30g of alcohol/day is associated with lower levels of markers of systemic inflammation (Imhof et al, 2004; Pai et al, 2006; Raum et al, 2007), with some data suggesting these effects are maintained up to alcohol use at 20–70g/day (Wang et al, 2008). An alcohol-intake-controlled trial has, found that drinking 30g of alcohol per day (i.e., two drinks) for 12-weeks resulted in lower levels of CRP as compared to abstinence (Estruch et al, 2004), with similar results for those that drank 30–40g of alcohol per day for 3-weeks (Sierksma et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

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To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

O’Connor

Bower

Cho

et al. 2009

Brain, Behavior, and Immunity

442

401

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Behavioral scientists have increasingly included inflammatory biology as mechanisms in their investigation of psychosocial dynamics on the pathobiology of disease. However, a lack of standardization of inclusion and exclusion criteria and assessment of relevant control variables impacts the interpretation of these studies. The present paper reviews and discusses human biobehavioral factors that can affect the measurement of circulating markers of inflammation. Keywords relevant to inflammatory biology and biobehavioral factors were searched through PubMed. Age, sex, and hormonal status, socioeconomic status, ethnicity and race, body mass index, exercise, diet, caffeine, smoking, alcohol, sleep disruption, antidepressants, aspirin, and medications for cardiovascular disease are all reviewed. A tiered set of recommendations as to whether each variable should be assessed, controlled for, or used as an exclusion criteria is provided. These recommendations provide a framework for observational and intervention studies investigating linkages between psychosocial and behavioral factors and inflammation.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

O’Connor

Bower

Cho

et al. 2009

Brain, Behavior, and Immunity

442

401

View full text Add to dashboard Cite

show abstract

“…Smoking is known to increase CRP levels [36]. Given the similar demographic characteristics of the MDD and control study subjects, the increased CRP levels in women with MDD are unlikely related to different life style habits, except for a possible minor effect of lower alcohol intake [37]. …”

Section: Discussionmentioning

confidence: 99%

Plasma CRP Levels in Premenopausal Women with Major Depression: A 12-Month Controlled Study

Cizza¹,

Eskandari²,

Coyle³

et al. 2009

Horm Metab Res

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C-reactive protein (CRP), an inflammatory marker of cardiovascular risk, is often elevated in major depressive disorder (MDD). The magnitude and consistency of this elevation have not been previously characterized in premenopausal women with MDD. The aim of the study was to prospectively assess plasma CRP levels, body composition, endocrine and metabolic parameters, and depressive status in premenopausal women with MDD (n = 77) and controls (n = 41), aged 21 to 45. Women were enrolled in a 12-month, controlled study of bone turnover, the P.O.W.E.R. (Premenopausal, Osteoporosis, Women, Alendronate, Depression) Study. Blood samples were taken at Baseline, Month 6, and Month 12. Most subjects with MDD were in clinical remission. These women tended to have consistently higher CRP levels than controls over 12 months (p = 0.077). BMI was positively related to log[CRP] in women with MDD only. Nine women with MDD had CRP levels greater than 10 mg/l, a value associated with a very high cardiovascular risk. This subset was obese and had significantly higher triglycerides, total cholesterol, LDL-cholesterol, fasting insulin, and HOMA-IR than the rest of women with MDD. The variations in CRP levels over time were high (intra- and inter-individual coefficients of variations of ∼30–50% and ∼70–140%, respectively). No control had CRP levels greater than 10 mg/l. Depression was associated with increased plasma CRP in women with MDD. The clinical significance of abnormal plasma CRP for cardiovascular risk needs to be assessed in large prospective studies of women with depression.

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“…However, most previous studies of the relationship of alcohol consumption with hemostatic and inflammatory factors have been cross-sectional [5, 8, 10, 13] or were restricted to Caucasians [5, 6, 8, 10, 11, 13]. African American (but no other minority) women have been included in a few studies [7, 9].…”

Section: Introductionmentioning

confidence: 99%

Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years: The study of women's health across the nation (SWAN)

Janssen

Landay

Ruppert

et al. 2014

Nutrition and Aging

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Long-term and short-term alcohol consumption and levels of C-reactive protein

Cited by 21 publications

References 14 publications

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

Plasma CRP Levels in Premenopausal Women with Major Depression: A 12-Month Controlled Study

Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years: The study of women's health across the nation (SWAN)

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