Long-term antibody response after measles vaccination in an isolated arctic society in Greenland

Pedersen, Ib Rode; Mordhorst, C.H.; Ewald, T arsila; Magnus, H. Von

doi:10.1016/0264-410x(86)90006-x

Cited by 31 publications

(12 citation statements)

References 14 publications

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“…Our data can be used to estimate the frequency of susceptibles on the basis of their pre-existing IgG, NT and HI levels. Since after vaccination antibody titres are lower and more likely to wane than after wild-type infection [6,[21][22][23], such estimates may become relevant to future MV epidemiology and vaccination strategies.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors

Huiss

Damien²,

Schneider

et al. 1997

Clinical and Experimental Immunology

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SUMMARYAmong 44 fully protected, late convalescent adults re-exposed to measles, four developed an asymptomatic secondary immune response (SIR) with a significant increase in measles virus (MV)-specific IgG and low IgM. The boosted antibodies were mainly of the IgG1 subclass and reacted with the nucleoprotein and the haemagglutinin protein. About 30 weeks after re-exposure, antibody levels had decreased by 35-50%, suggesting that the booster effect may only be transient. SIR was only found in individuals with a pre-exposure

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Section: Discussionmentioning

confidence: 99%

Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors

Huiss

Damien²,

Schneider

et al. 1997

Clinical and Experimental Immunology

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“…In most published studies, it has been reported that in a secondary immune response following virus immunogenic contact, there is an increase in antimeasles virus IgG antibody titer, usually without detectable production of antimeasles IgM (3,15). There also have been reports indicating that both measles IgG and IgM might be detected in some patients with secondary immune response (3,8,11,15,17).…”

Section: Discussionmentioning

confidence: 93%

“…There also have been reports indicating that both measles IgG and IgM might be detected in some patients with secondary immune response (3,8,11,15,17). However, it is accepted worldwide that a restrictive case definition of secondary immune response excludes measles IgMpositive individuals.…”

Section: Discussionmentioning

confidence: 95%

Immunoglobulin M Antibody Response to Measles Virus Following Natural Virus Infection, Primary Vaccination, and Reexposure to the Virus

Nates

Rey²,

Giordano³

et al. 1997

Viral Immunology

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Evaluation of the measles virus ELISA kit (Merck) to detect specific IgM as an indicator of primary measles antibody response was carried out. A modification of the manufacturer's cutoff value interpretation was introduced to allow for equivocal results in addition to positive and negative ones. With this modification, the test assayed gave an overall reproducibility of 96.16%. The IgM seropositivity rate for seroneutralization-confirmed measles cases was 100% for naturally infected measles subjects and 90% for primary measles vaccinated subjects. Individuals with positive neutralizing antimeasles antibodies in close contact with a confirmed measles case gave the following measles IgM ELISA results: 54.54% negative, 9.09% positive, and 36.36% equivocal, showing a booster with IgM antibody response on reexposure to the virus. Positive subjects with neutralizing antimeasles antibodies without recent contact with a measles case gave negative IgM results. IgM seropositivity was strongly associated with IgG seroconversion and clinical measles (p < 0.0001). The technique assayed performed adequately for the confirmation of both measles natural infection and primary vaccination and for the differentiation of primary and secondary antibody response, taking into account the modification in the cutoff value interpretation introduced and providing that the serum samples are obtained between days 5 and 30 after onset of rash.

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“…21,22 In addition, evidence of waning immunity was found in vaccinated individuals. [23][24][25][26] When measles out- Seroepidemiological studies provide information on the appropriate timing of supplemental administration, warnings about the accumulation of susceptible individuals, and information on the infl uence of measles outbreaks. In addition, the long-term effects of vaccination and natural infection on population immunity have not been fully investigated in Japan.…”

Section: Measles Serological Epidemiologymentioning

confidence: 99%

Current status of measles in Japan: molecular and seroepidemiological studies

2007

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On account of the measles vaccination campaign, with vaccinations carried out on the first birthdays of children, the number of reported cases of measles was reduced to 545 in 2005, which is the lowest so far in Japan. We conducted a molecular epidemiological study of measles virus to determine the circulating measles virus genotypes in Japan since 1984. Different genotypes, C1, D3, D5, and H1, were the major strains isolated in outbreaks in 1984, 1987-1988, 1991-1993, and 2000, respectively. When measles was in the control phase, a sporadic outbreak was reported, but the causative virus was found to be of imported measles virus lineage. We also conducted a seroepidemiological study to investigate the persistence of vaccine-acquired immunity in Himeji City, Japan. Before 1990, vaccine coverage was 84.5% and it increased gradually, to 88.5% in 1991-1995, 92.7% in 1996-2000, and 94.6% after 2000. Measles outbreaks were observed annually before 1978 and in 1980, 1981, 1984, 1990, and 1996; there were no measles cases after 1997 in Himeji City. In 1994-1998, a serological study of 795 sera showed that measles neutralization test (NT) antibodies were sufficiently preserved, even 12 years after the first-dose immunization. In 1999-2003, 26 (3.7%) of 695 sera were negative for NT. The positive rate for measles NT decreased to approximately 90% as the elapsed time after the first-dose immunization increased to 6 or 7 years. The immunity obtained after receiving measles vaccine decays by 6-7 years after the first dose when the measles was controlled. A two-dose schedule of measles vaccine was implemented in Japan in 2006; we should continue molecular and serological surveillance.

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Long-term antibody response after measles vaccination in an isolated arctic society in Greenland

Cited by 31 publications

References 14 publications

Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors

Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors

Immunoglobulin M Antibody Response to Measles Virus Following Natural Virus Infection, Primary Vaccination, and Reexposure to the Virus

Current status of measles in Japan: molecular and seroepidemiological studies

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