Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Škrlová, Kateřina; Rybková, Zuzana; Stachurová, Tereza; Zagora, Jakub; Malachová, Kateřina; Měřínská, Dagmar; Gabor, Roman; Havlíček, Miroslav; Muñoz‐Bonilla, Alexandra; Plachá, Daniela

doi:10.1016/j.polymertesting.2022.107760

Cited by 7 publications

(4 citation statements)

References 68 publications

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“…A typical polymer exhibiting antibacterial properties contains cationic groups that allow its adsorption on the anionic membrane and affect the deterioration of the cell membrane by interfering with the transport of compounds and hydrophobic groups that insert into and disrupt the bilipid membrane [ 14 , 15 ]. Polylactide itself or its copolymers indeed have a noticeable bacteriostatic effect [ 16 ]. However, it is insignificant and limited.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

et al. 2023

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The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on 1H NMR, FTIR, GPC, and DSC tests. Terpolymers differed in the content of amino and hydroxyl groups. The values of average molecular mass oscillated from about 5000 g/mol to less than 15,000 g/mol. Depending on the length of the hydrophilic block and its composition, the value of the contact angle ranged from 50° to 20°. The terpolymers containing amino groups, capable of forming strong intra- and intermolecular bonds, show a high degree of crystallinity. The endotherm responsible for the melting of L-lactidyl semicrystalline regions appeared in the range from about 90 °C to close to 170 °C, with a heat of fusion from about 15 J/mol to over 60 J/mol.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

et al. 2023

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“…Since PLA is sensitive to all available sterilizing methods [ 26 ] and can become easily contaminated after sterilization, antibacterial components are frequently added to it. The range of antibacterial agents introduced so far has been vast: antibiotics [ 27 ], antibacterial peptides [ 28 , 29 ], chitosan [ 23 , 30 , 31 ], essential oils, volatile plant extracts, and other natural antimicrobials [ 23 , 32 , 33 , 34 , 35 ], but also various inorganic nanomaterials—in particular, silver [ 36 , 37 , 38 , 39 , 40 , 41 ], copper [ 13 , 39 ], and metal oxides (TiO 2 [ 39 ], ZnO [ 42 , 43 , 44 ], MgO [ 45 , 46 ], CaO [ 47 ]).…”

Section: Introductionmentioning

confidence: 99%

Nanogallium-poly(L-lactide) Composites with Contact Antibacterial Action

Kurtjak,

Maček Kržmanc,

Spreitzer

et al. 2024

Pharmaceutics

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In diverse biomedical and other applications of polylactide (PLA), its bacterial contamination and colonization are unwanted. For this reason, this biodegradable polymer is often combined with antibacterial agents or fillers. Here, we present a new solution of this kind. Through the process of simple solvent casting, we developed homogeneous composite films from 28 ± 5 nm oleic-acid-capped gallium nanoparticles (Ga NPs) and poly(L-lactide) and characterized their detailed morphology, crystallinity, aqueous wettability, optical and thermal properties. The addition of Ga NPs decreased the ultraviolet transparency of the films, increased their hydrophobicity, and enhanced the PLA structural ordering during solvent casting. Albeit, above the glass transition, there is an interplay of heterogeneous nucleation and retarded chain mobility through interfacial interactions. The gallium content varied from 0.08 to 2.4 weight %, and films with at least 0.8% Ga inhibited the growth of Pseudomonas aeruginosa PAO1 in contact, while 2.4% Ga enhanced the effect of the films to be bactericidal. This contact action was a result of unwrapping the top film layer under biological conditions and the consequent bacterial contact with the exposed Ga NPs on the surface. All the tested films showed good cytocompatibility with human HaCaT keratinocytes and enabled the adhesion and growth of these skin cells on their surfaces when coated with poly(L-lysine). These properties make the nanogallium-polyl(L-lactide) composite a promising new polymer-based material worthy of further investigation and development for biomedical and pharmaceutical applications.

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“…PLA is mainly used in the production of disposable consumer goods in the packaging industry, e.g., loose-fill packaging, compost bags, food packaging and disposable tableware [6] and in the textile industry, e.g., disposable clothing. It also has biomedical applications such as surgical threads, in the production of implants [7], scaffolds for bone regeneration [8] or drug delivery microsphere [9]. At the same time, the properties of polylactide depend on the constituent isomers, molecular weight, processing temperature and annealing time [10].…”

Section: Introductionmentioning

confidence: 99%

Study of Argon and Oxygen Mixtures in Low Temperature Plasma for Improving PLA Film Wettability

Izdebska‐Podsiadły

2023

Coatings

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Oxygen (O2) and argon (Ar) plasma give a significant improvement in the wettability of PLA films. This study investigates the effectiveness of plasma activation with a mixture of these two gases. The study includes contact angle measurements with water and diiodomethane and calculation of surface free energy (SFE) together with its polar and dispersion components. In addition, a chemical analysis of the surface, surface roughness, weight loss and the change in tensile strength were examined. As a result of the study, it was found that the use of a mixture of oxygen and argon during the plasma activation of the polylactide film gives better improvement in wettability than the use of pure gases. Moreover, the use of a mixture of these gases in equal proportions turned out to be the most effective, providing the highest value of the SFE and its polar component, as well as the lowest value of the water contact angle. Furthermore, plasma activation with this gas mixture results in reduced surface etching compared to other gas compositions, which manifests itself in lower weight reduction and an insignificant change in tensile strength.

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Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Cited by 7 publications

References 68 publications

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

Nanogallium-poly(L-lactide) Composites with Contact Antibacterial Action

Study of Argon and Oxygen Mixtures in Low Temperature Plasma for Improving PLA Film Wettability

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