Long-term assessment of aspirin desensitization shows successful bridging with non-aspirin nonsteroidal anti-inflammatory drugs for procedures

Symptom Control of Patients With Chronic Rhinosinusitis With Nasal Polyps Under Maintenance Therapy With Daily Acetylsalicylic Acid

“…An interesting aspect of this last mentioned study is the effective bridging of NERD patients under ASA maintenance therapy with ibuprofen before and during elective surgical procedures. 25 Although other therapeutic options have not been fully established, some hold promise in the treatment of NERD: Omalizumab has been shown to decrease proinflammatory mediators 16,26 and the monoclonal antibody against interleukin 4 and interleukin 13; dupilumab is now officially approved by the Food and Drug Administration to treat therapy-resistant chronic sinonasal symptoms. 26…”

“…An interesting aspect of this last mentioned study is the effective bridging of NERD patients under ASA maintenance therapy with ibuprofen before and during elective surgical procedures. 25…”

Perioperative management and perceived risks of sinus surgery in patients with aspirin‐exacerbated respiratory disease

“…3 There are currently 2 perioperative protocols available for AERD patients on high-dose aspirin. One protocol proposed by Do et al involves an ibuprofen bridge, 4 and the other previously unpublished protocol involves continuation of aspirin at a lower dose (Table 1). The awareness of and adherence to these protocols among surgeons is unknown.…”

Peanuta non grata revisited

“…4 The two other respiratory disease articles in this issue addressed topics related to the treatment of aspirin-exacerbated respiratory disease (AERD). Do et al 5 retrospectively assessed 36 subjects with AERD who underwent successful aspirin desensitization. Their goal was to compare the long-term effects of different maintenance doses of aspirin and to study the success of bridging subjects with AERD for surgery by substituting an alternative nonsteroidal anti-inflammatory drug (ibuprofen) in place of aspirin therapy.…”

“…They reported that, although no differences in efficacy benefits was found between an aspirin dose of 325 mg once or twice daily compared with 650 mg once or twice daily, they cautiously admitted that the studies may have been limited by the small number of subjects studied. 5 The investigators suggested that bridging surgical patients with AERD by using ibuprofen seemed to be a safe and effective therapeutic regiment in maintaining aspirin desensitization.…”